Journal ArticleDOI
Solid lipid nanoparticles (SLN) of Efavirenz as lymph targeting drug delivery system: Elucidation of mechanism of uptake using chylomicron flow blocking approach.
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TLDR
The results from lymphatic transport and tissue distribution study indicate that a significant part of the EFV had by-passed portal system and was recovered in the lymph via chylomicron uptake mechanism, indicating that major amount of EFV bypasses the liver and thereby, enhances the oral bioavailability of theEFV.About:
This article is published in International Journal of Pharmaceutics.The article was published on 2015-11-10. It has received 142 citations till now.read more
Citations
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Journal ArticleDOI
Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems: applications, advantages and disadvantages.
TL;DR: The aim of this article is to review the advantages and limitations of these delivery systems based on the route of administration and to emphasis the effectiveness of such formulations.
Journal ArticleDOI
Recent advances in oral delivery of drugs and bioactive natural products using solid lipid nanoparticles as the carriers.
TL;DR: This article systematically introduces the concepts and amelioration mechanisms of the nanomedical techniques for drug- and natural compound-loaded SLNs.
Journal ArticleDOI
Nanotechnology-based antiviral therapeutics.
Malobika Chakravarty,Amisha Vora +1 more
TL;DR: The authors highlight newer promising treatment approaches like nanotraps, nanorobots, nanobubbles, nanofibers, nanodiamonds, nanovaccines, and mathematical modeling for the future.
Journal ArticleDOI
Solid lipid nanoparticles: a review on recent perspectives and patents.
TL;DR: In this review, the authors have covered areas from the basic introduction of SLNs to its applications in controlled drug delivery and patents disclosed related to the SLNs for the period 2014–2019.
Journal ArticleDOI
Pharmaceutical Dispersion Techniques for Dissolution and Bioavailability Enhancement of Poorly Water-Soluble Drugs
TL;DR: This article reviews the most commonly used dispersion techniques for pharmaceutical processing that can practically enhance the dissolution and bioavailability of poorly water-soluble drugs.
References
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Journal ArticleDOI
Solid lipid nanoparticles: Production, characterization and applications
W. Mehnert,Karsten Mäder +1 more
TL;DR: An overview about the selection of the ingredients, different ways of SLN production and SLN applications, and the in vivo fate of the carrier are presented.
Journal ArticleDOI
Lipid-based formulations for intestinal lymphatic delivery.
TL;DR: The success and limitations of a formulation approach using lipid-based vehicles are analyzed, potential areas for further research are highlighted and a deeper appreciation of all the mechanisms is still unrealized.
Journal ArticleDOI
Lipid-based delivery systems and intestinal lymphatic drug transport : A mechanistic update
TL;DR: The mechanisms by which drug molecules access the lymph and the formulation strategies that may be utilised to enhance lymphatic drug transport are described, directed toward recent advances in understanding regarding the impact of lipid source and intracellular lipid trafficking pathways.
Journal ArticleDOI
Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration.
TL;DR: SLN are suitable drug delivery system for the improvement of bioavailability of lipophilic drugs such as clozapine and in tested organs, the AUC and MRT of clozAPine SLNs were higher than those of clazapine suspension especially in brain and reticuloendothelial cell-containing organs.
Journal ArticleDOI
Solid lipid nanoparticles (SLNs) to improve oral bioavailability of poorly soluble drugs.
Lian-Dong Hu,Xing Tang,Fu-De Cui +2 more
TL;DR: Results indicate that ATRA absorption is enhanced significantly by employing SLN formulations, and SLNs offer a new approach to improve the oral bioavailability of poorly soluble drugs.
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Solid lipid nanoparticles: Production, characterization and applications
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