Solid self-nanoemulsifying drug delivery system (S-SNEDDS) of darunavir for improved dissolution and oral bioavailability: In vitro and in vivo evaluation.
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Cites methods from "Solid self-nanoemulsifying drug del..."
...But, the reason behind higher extent of absorption and bioavailability from S-SNEDDS compared to L-SNEDDS is not clear from the authors view other than general hypothesized mechanisms of improved pharmacokinetics from SNEDDS that have been already explained in this review earlier....
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...The in vivo studies showed 2–2.5 times higher Cmax and 2–3 times higher AUC0– values obtained after oral administration of L-SNEDDS and S-SNEDDS to Wistar albino rats compared to normal drug suspension....
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...Darunavir, a poorly soluble drug was formulated as liquid SNEDDS (L-SNEDDS) containing Capmul MCM (a medium chain triglyceride) followed by conversion to a solid powder (S-SNEDDS) (Inugala et al., 2015)....
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...…Transcutol P 101 ± 4 SNEDDS (Kang et al., 2012) Diclofenac Sodium NR 137 SNEDDS (Kumar et al., 2015) Darunavir Capmul MCM C8, tween 80, transcutol P 144 ± 2.3 SNEDDS (Inugala et al., 2015) MCT: Medium chain triglyceride; TPGS: D-alpha-tocopheryl polyethylene glycol 1000 succinate; NR: Not reported....
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...The initial rate of Darunavir absorption was higher in the case of L-SNEDDS, but the AUC0– value was higher in the case of S-SNEDDS (32.28 ± 2.5 mg.h/ml) than L-SNEDDS (22.9 ± 2.1 mg.h/ml)....
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References
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"Solid self-nanoemulsifying drug del..." refers methods in this paper
...%) was calculated using tapped density (Pt) and poured bulk density (Pb) of S-SNEDDS formulation (Carr, 1965)....
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928 citations
"Solid self-nanoemulsifying drug del..." refers methods in this paper
...From the dissolution profiles, various dissolution parameters like dissolution efficiency (DE), mean dissolution time (MDT) and mean dissolution rate (MDR) were calculated out (Khan, 1975; Eedara et al., 2013)....
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640 citations
"Solid self-nanoemulsifying drug del..." refers background in this paper
...SNEDDS are preconcentrates composed of isotropic mixtures of oils, surfactants, co-surfactants which spontaneously form a fine oil in water (o/w) emulsion in situ upon contact with aqueous medium with a globule size in the range of 20–200 nm (Porter et al., 2008)....
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518 citations
"Solid self-nanoemulsifying drug del..." refers methods in this paper
...In vitro drug release studies In vitro drug release behaviour of drug from pure darunavir and L-SNEDDS dispersion was determined using modified dialysis method (Kang et al., 2004)....
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514 citations
"Solid self-nanoemulsifying drug del..." refers background in this paper
...The fatty acid composition is 70% oleic acid with several other fatty acids such as palmitic acid (Shah et al., 1994)....
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...The variation in fatty acid carbon chain lengths of oil, surfactant and their degree of un-saturation plays a significant role in rapid self-emulsification with small globule size and stability of formed emulsion (Shah et al., 1994)....
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