Journal ArticleDOI
Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells
Carmen Urbich,Alexandra Aicher,Christopher Heeschen,Elisabeth Dernbach,Wolf K. Hofmann,Andreas M. Zeiher,Stefanie Dimmeler +6 more
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TLDR
EPC exhibit a high expression of angiogenic growth factors, which enhanced migration of mature endothelial cells and tissue resident cardiac progenitor cells, and the enhanced expression of cytokines may be a supportive mechanism to improve blood vessel formation and cardiac regeneration after cell therapy.About:
This article is published in Journal of Molecular and Cellular Cardiology.The article was published on 2005-11-01. It has received 765 citations till now. The article focuses on the topics: Endothelial stem cell & Vasculogenesis.read more
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Journal ArticleDOI
Paracrine Mechanisms in Adult Stem Cell Signaling and Therapy
TL;DR: The potential paracrine mechanisms involved in adult stem cell signaling and therapy are reviewed: cytokines and growth factors can induce cytoprotection and neovascularization, and cardiac remodeling, contractility, and metabolism may also be influenced in aParacrine fashion.
Journal ArticleDOI
Endothelial progenitor cell derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA.
Maria Chiara Deregibus,Vincenzo Cantaluppi,Raffaele A. Calogero,Marco Lo Iacono,Ciro Tetta,Luigi Biancone,Stefania Bruno,Benedetta Bussolati,Giovanni Camussi +8 more
TL;DR: Protein expression and functional studies showed that PI3K and eNOS play a critical role in the angiogenic effect of MVs, suggesting that EPCs may activate angiogenesis in endothelial cells by releasing MVs able to trigger an angiogens program.
Journal ArticleDOI
Adult bone marrow-derived cells for cardiac repair: a systematic review and meta-analysis.
Ahmed Abdel-Latif,Roberto Bolli,Imad M. Tleyjeh,Victor M. Montori,Emerson C. Perin,Carlton A. Hornung,Ewa K. Zuba-Surma,Mouaz H. Al-Mallah,Buddhadeb Dawn +8 more
TL;DR: The available evidence suggests that BMC transplantation is associated with modest improvements in physiologic and anatomic parameters in patients with both acute myocardial infarction and chronic ischemic heart disease, above and beyond conventional therapy.
Journal ArticleDOI
Diabetic impairments in NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF-1α
Katherine A. Gallagher,Zhao-Jun Liu,Min Xiao,Haiying Chen,Lee J. Goldstein,Donald G. Buerk,April Nedeau,Stephen R. Thom,Omaida C. Velazquez +8 more
TL;DR: Administration of SDF-1alpha into wounds reversed the EPC homing impairment and, with hyperoxia, synergistically enhanced EPC mobilization, homing, and wound healing, which can significantly advance the field of diabetic wound healing.
Journal ArticleDOI
Critical Reevaluation of Endothelial Progenitor Cell Phenotypes for Therapeutic and Diagnostic Use
TL;DR: The most commonly used protocols to define EPCs by culture assays or by fluorescence-activated cell sorter in the context of their therapeutic or diagnostic use are critically reviewed.
References
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Journal ArticleDOI
The biology of VEGF and its receptors.
TL;DR: Vascular endothelial growth factor (VEGF) is a key regulator of physiological angiogenesis during embryogenesis, skeletal growth and reproductive functions and is implicated in pathologicalAngiogenesis associated with tumors, intraocular neovascular disorders and other conditions.
Journal ArticleDOI
Isolation of putative progenitor endothelial cells for angiogenesis.
Takayuki Asahara,Toyoaki Murohara,Alison Sullivan,Marcy Silver,Rien van der Zee,Tong Li,Bernhard Witzenbichler,Gina C. Schatteman,Jeffrey M. Isner +8 more
TL;DR: It is suggested that EC progenitors may be useful for augmenting collateral vessel growth to ischemic tissues (therapeutic angiogenesis) and for delivering anti- or pro-angiogenic agents, respectively, to sites of pathologic or utilitarianAngiogenesis.
Journal ArticleDOI
Angiogenesis in cancer and other diseases
Peter Carmeliet,Rakesh K. Jain +1 more
TL;DR: Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases and integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases, but owing to several unanswered questions, caution is needed.
Journal ArticleDOI
Adult Cardiac Stem Cells Are Multipotent and Support Myocardial Regeneration
Antonio Paolo Beltrami,Laura Barlucchi,Daniele Torella,Mathue Baker,Federica Limana,Stefano Chimenti,Hideko Kasahara,Marcello Rota,Ezio Musso,Konrad Urbanek,Annarosa Leri,Jan Kajstura,Bernardo Nadal-Ginard,Piero Anversa +13 more
TL;DR: The existence of Lin(-) c-kit(POS) cells with the properties of cardiac stem cells, which are self-renewing, clonogenic, and multipotent, giving rise to myocytes, smooth muscle, and endothelial cells are reported.
Journal ArticleDOI
Bone Marrow Origin of Endothelial Progenitor Cells Responsible for Postnatal Vasculogenesis in Physiological and Pathological Neovascularization
Takayuki Asahara,Haruchika Masuda,Tomono Takahashi,Christoph Kalka,Christopher Pastore,Marcy Silver,Marianne Kearne,Meredith Magner,Jeffrey M. Isner +8 more
TL;DR: Findings indicate that postnatal neovascularization does not rely exclusively on sprouting from preexisting blood vessels (angiogenesis); instead, EPCs circulate from bone marrow to incorporate into and thus contribute to postnatal physiological and pathological neov vascularization, which is consistent with postnatal vasculogenesis.
Related Papers (5)
Endothelial Progenitor Cells: Characterization and Role in Vascular Biology
Carmen Urbich,Stefanie Dimmeler +1 more