Book•
Solvent-free organic synthesis
01 Jan 2003-
TL;DR: In this paper, the authors proposed a Solvent Free Organic Synthesis (SOS) method for organic synthesis, which is a state-of-the-art method for solvent-free organic synthesis.
Abstract: Solvent-free organic synthesis , Solvent-free organic synthesis , کتابخانه دیجیتال جندی شاپور اهواز
Citations
More filters
TL;DR: This paper presents a new approach to solvent-free organic synthesis called “Solvent-free synthesis with real-time stoichiometry” that combines high-performance liquid chromatography and high-tech electronics.
Abstract: Solvent-free organic synthesis , Solvent-free organic synthesis , کتابخانه دیجیتال جندی شاپور اهواز
1,004 citations
23 May 2016
TL;DR: A review of general purpose solvent selection guides can be found in this paper, highlighting their similarities and differences and how they can be used to enhance the greenness of chemical processes, particularly in laboratory organic synthesis and the pharmaceutical industry.
Abstract: Driven by legislation and evolving attitudes towards environmental issues, establishing green solvents for extractions, separations, formulations and reaction chemistry has become an increasingly important area of research Several general purpose solvent selection guides have now been published with the aim to reduce use of the most hazardous solvents This review serves the purpose of explaining the role of these guides, highlighting their similarities and differences How they can be used most effectively to enhance the greenness of chemical processes, particularly in laboratory organic synthesis and the pharmaceutical industry, is addressed in detail
756 citations
TL;DR: Host frameworks constructed with various pillars display metric interdependences among specific structural features that reveal a common mechanism by which these soft frameworks adapt to different guests, facilitating structure prediction and providing guidance for the design of inclusion compounds based on these hosts.
Abstract: The self-assembly and solid-state structures of host-guest inclusion compounds with lamellar architectures based on a common building block, a resilient hydrogen-bonded sheet consisting of guanidinium ions and sulfonate moieties of organodisulfonate "pillars", are described. The pillars connect adjacent sheets to generate galleries with molecular-scale cavities occupied by guest molecules. The size, shape, and physicochemical character of the inclusion cavities can be systematically adjusted by interchanging framework components while maintaining the lamellar architecture, enabling prediction and control of crystal lattice metrics with a precision that is unusual for "crystal engineering". The reliability of the lamellar architecture is a direct consequence of conformational flexibility exhibited by these hosts that, unlike rigid systems, enables them to achieve optimal packing with guest molecules. The adaptability of these hosts is further reflected by an architectural isomerism that is driven by guest templating during assembly of the inclusion compounds. Host frameworks constructed with various pillars display metric interdependences among specific structural features that reveal a common mechanism by which these soft frameworks adapt to different guests. This unique feature facilitates structure prediction and provides guidance for the design of inclusion compounds based on these hosts.
527 citations
TL;DR: This tutorial review focuses on recent research into the use of mechanochemistry (grinding) to synthesise metal complexes in the absence of solvent, including synthesis of mononuclear complexes, coordination clusters, spacious coordination cages, and 1-, 2- and 3-dimensional coordination polymers (metal organic frameworks) which can even exhibit microporosity.
Abstract: Avoiding the use of solvents in synthesis can reduce environmental contamination and even be more convenient than using solvent-based synthesis. In this tutorial review we focus on recent research into the use of mechanochemistry (grinding) to synthesise metal complexes in the absence of solvent. We include synthesis of mononuclear complexes, coordination clusters, spacious coordination cages, and 1-, 2- and 3-dimensional coordination polymers (metal organic frameworks) which can even exhibit microporosity. Remarkably, in many cases, mechanochemical synthesis is actually faster and more convenient than the original solvent-based methods. Examples of solvent-free methods other than grinding are also briefly discussed, and the positive outlook for this growing topic is emphasised.
520 citations
TL;DR: In this paper, the authors considered non-conventional conditions: alternative coupling partners, ligandless, solid support, scCO 2, ionic liquds, fluorous media, water, microwave, ultrasound, micelles, microreactors, ball mill.
481 citations
References
More filters
287 citations
TL;DR: Etude de l'oxydation de phenols tels que les naphtol-2, naphtalenediol-2 and dihydro-9,10 anthracenone-9.
Abstract: Etude de l'oxydation de phenols tels que les naphtol-2, naphtalenediol-2,3 et de dihydro-9,10 anthracenone-9
240 citations
TL;DR: In this article, the role of packing in the crystal of substituted coumarins has been investigated and the results pertaining to subtler aspects of topochemical postulates have been obtained.
Abstract: Solid-state photochemical behavior of 28 substituted coumarins has been investigated. Of these twelve underwent photodimerization and this is remarkable in light of the inertness of coumarin itself in the solid state. X-ray crystallographic investigation of eight coumarins was undertaken with the view of understanding the role of packing in the crystal on their solid-state reactivity. Important findings include the identification of acetoxy and chloro substituents as useful “crystal engineering” groups and the results pertaining to subtler aspects of topochemical postulates. X-ray crystal structure analyses of 7-chlorocoumarin and 7-methoxycoumarin reveal packing modes which are not commonly met. The former is arranged in a \beta type packing, the center-center distance between the reactive double bonds being 4.454 \AA, which lies beyond the so far accepted limit of 3.5-4.2 \AA. The reactive double bonds of 7-methoxycoumarin, on the other hand, are rotated by $65^O$ with respect to each other with the center-center distance between the double bonds being 3.83 \AA. Inspite of these unfavorable arrangements photodimerization of the above two coumarins in the solid state occurs through a topochemical process with large dimer yields. A careful analysis of the X-ray crystallographic resulta obtained from our investigations reveals that the two double bonds in the reactive crystals may be displaced with respect to each other both along the molecular plane as well as along the double bond axis. Thus the normally accepted dictums that in the photoreactive crystals the doube bonds should be within a distance of 4.2 \AA, and that they be parallel are no longer operational.
209 citations
TL;DR: Some host-guest complexes have been formed by mixing the components in the solid state, and complexation has been shown to proceed with some selectivity as mentioned in this paper, however, the complexity of these complexes is limited.
Abstract: Some host–guest complexes have been formed by mixing teh components in the solid state, and complexation has been shown to proceed with some selectivity.
158 citations