Journal ArticleDOI
South American Plants II: Taspine Isolation and Anti-Inflammatory Activity
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TLDR
Croton lechleri L. (Euphorbiaceae), a plant from the Upper Amazon Valley of Peru, yielded the alkaloid taspine, which was studied using the carrageenan-induced pedal edema method, the cotton pellet-induced granuloma method, and the adjuvant polyarthritis model.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1979-01-01. It has received 80 citations till now. The article focuses on the topics: Taspine & Croton lechleri.read more
Citations
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Dragon's blood : Botany, chemistry and therapeutic uses
TL;DR: This review has tried to overview different sources of Dragon's blood, its source wise chemical constituents and therapeutic uses.
Journal ArticleDOI
Anti-inflammatory activity of alkaloids: a twenty-century review
José Maria Barbosa-Filho,Marcia Regina Piuvezam,Marcelo de Oliveira Moura,Marcelo Sobral da Silva,Karla V. Batista Lima,Emídio V. L. da-Cunha,Emídio V. L. da-Cunha,Ivana Maria Fechine,Orlando Seiko Takemura +8 more
TL;DR: In this paper, a review shows some alkaloids of vegetal origin which in the period of 1907 to 2000 were evaluated regarding a possible anti-inflammatory activity, and among those, the isoquinoline type was the most studied.
Journal ArticleDOI
Overcoming tumor multidrug resistance using drugs able to evade P‐glycoprotein or to exploit its expression
TL;DR: The possibility of overcoming MDR using the development of new anticancer drugs which are not substrates of P‐gp and the use of molecules whose activity takes advantage of the overexpression of Pglycoprotein.
Journal ArticleDOI
Polyphenolic compounds from Croton lechleri
Ya Cai,Fred J. Evans,Margaret F. Roberts,J. D. Phillipson,M. H. Zenk,M. H. Zenk,Y.Y. Gleba,Y.Y. Gleba +7 more
TL;DR: A new procedure combining chemical degradation with 1H NMR spectroscopy has been developed for determination of the composition and molecular size of oligomeric/polymeric proanthocyanidins.
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SP-303, an antiviral oligomeric proanthocyanidin from the latex of Croton lechleri (Sangre de Drago).
R. P. Ubillas,Shivanand D. Jolad,Reimar C. Bruening,M. R. Kernan,S.R. King,David F. Sesin,Marilyn Barrett,Cheryl A. Stoddart,T. Flaster,J. E. Kuo,F. Ayala,E. Meza,M. Castañel,D. Mcmeekin,Edward J. Rozhon,Michael S. Tempesta,Dale L. Barnard,John H. Huffman,Donald F. Smee,Robert W. Sidwell,K. Soike,A. Brazier,S. Safrin,Ron Orlando,Peter T.M. Kenny,N. Berova,Koji Nakanishi +26 more
References
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A simplified method of evaluating dose-effect experiments.
J. T. Litchfield,F Wilcoxon +1 more
TL;DR: The method provides means for the rapid test of parallelism of two curves and easy computation of relative potency with its confidence limits and its accuracy is commensurate with the nature of dose-per cent effect data.
Journal Article
A simplified method of evaluating dose-effect experiments
J. T. Litchfield,F Wilcoxon +1 more
TL;DR: In this article, a rapid graphic method for approximating the median effective dose and the slope of dose-per-cent effect curves is presented, and confidence limits of both of these parameters for 19/20 probability are given by the method.
Journal Article
Comparative effect of antirheumatic drugs on adjuvant-induced polyarthritis in rats
John R. Ward,R. Sidney Cloud +1 more
TL;DR: Adjuvant arthritis of rats is established as an experimental model for testing antiartliritic drugs and it is suggested that this model would be more useful for drug evaluation with improved techniques for measuring joint swelling and tenderness.
Journal ArticleDOI
A biogenetically patterned conversion of magnoflorine into taspine
Maurice Shamma,Jerome L. Moniot +1 more
TL;DR: Ozonation of diacetylmagnoflorine methine followed by oxidation and lactonization affords taspine, which is then converted to methine by reaction of methine with Na6(CO3)SO4 and Na2SO4.
Related Papers (5)
SP-303, an antiviral oligomeric proanthocyanidin from the latex of Croton lechleri (Sangre de Drago).
R. P. Ubillas,Shivanand D. Jolad,Reimar C. Bruening,M. R. Kernan,S.R. King,David F. Sesin,Marilyn Barrett,Cheryl A. Stoddart,T. Flaster,J. E. Kuo,F. Ayala,E. Meza,M. Castañel,D. Mcmeekin,Edward J. Rozhon,Michael S. Tempesta,Dale L. Barnard,John H. Huffman,Donald F. Smee,Robert W. Sidwell,K. Soike,A. Brazier,S. Safrin,Ron Orlando,Peter T.M. Kenny,N. Berova,Koji Nakanishi +26 more