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Journal ArticleDOI

Specific complexation with mono- and disaccharides that can be detected by circular dichroism

01 Jun 1991-Journal of Organic Chemistry (American Chemical Society)-Vol. 56, Iss: 13, pp 4089-4091
TL;DR: The results indicate that the CD spectroscopic method using 2 as a receptor molecule serves as a nex sensory system for sugar molecules.
Abstract: For the development of receptor molecules that can recognize sugar molecules, we newly synthesized 2,2'-dimethoxydiphenylmethane-5,5'-diboronic acid (2). It was shown that in the presence of 2, D-glucose, D-maltose, D-cellobiose, and D-lactose result in a CD band at 275 nm. The results indicate that the CD spectroscopic method using 2 as a receptor molecule serves as a nex sensory system for sugar molecules
Citations
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Journal ArticleDOI
TL;DR: In this article, a method for examining boronate ester stability using the fluorescent reporter Alizarin Red S was developed, which was used to determine the binding constants of a series of diols, and as a basis from which to derive a number of relationships that correlate the various equilibrium constants in the literature.

1,260 citations

Patent
12 Sep 2005
TL;DR: In this paper, a telemetered characteristic monitor system includes a remotely located data receiving device, a sensor for producing signal indicative of a characteristic of a user, and a transmitter device.
Abstract: A telemetered characteristic monitor system includes a remotely located data receiving device, a sensor for producing signal indicative of a characteristic of a user, and a transmitter device. The transmitter device includes a housing, a sensor connector, a processor, and a transmitter. The transmitter receives the signals from the sensor and wirelessly transmits the processed signals to the remotely located data receiving device. The processor coupled to the sensor processes the signals from the sensor for transmission to the remotely located data receiving device. The data receiving device may be a characteristic monitor, a data receiver that provides data to another device, an RF programmer for a medical device, a medication delivery device (such as an infusion pump), or the like.

750 citations

Journal ArticleDOI
TL;DR: Supramolecular selective sensing of saccharides by using simple boronic acids in their aggregate forms is discussed, after a brief survey of the general aspects of boronics acid-based saccharide sensing.
Abstract: The reversible boronic acid–diol interaction empowers boronic acid receptors' saccharide binding capacities, rendering them a class of lectin mimetic, termed “boronlectins”. Boronic acids follow lectin functions not just in being able to bind saccharides, but in multivalent saccharide binding that enhances both affinity and selectivity. For almost a decade, efforts have been made to achieve and improve selectivity for given saccharide targets, most notably glucose, by using properly positioned boronic acids, offering multivalent interactions. Incorporation of several boronic acid groups into a covalent framework or non-covalent assembly of boronic acid are two general methods used to create such smart sensors, of which the latter resembles lectin oligomerisation that affords multivalent saccharide-binding architectures. In this review, we discuss supramolecular selective sensing of saccharides by using simple boronic acids in their aggregate forms, after a brief survey of the general aspects of boronic acid-based saccharide sensing.

487 citations

Journal ArticleDOI
TL;DR: Dynamic covalent functionality has been acknowledged as a powerful tool for the construction of organised architectures, the reversible nature thermodynamically facilitates self-control and self-correction.

426 citations

Patent
04 Sep 2002
TL;DR: In this article, a system and process for providing safety limits on the delivery of an infusion formulation by an infusion pump system in response to a sensed biological state is presented, where user-initiated event signals correspond to events that may significantly affect the biological state.
Abstract: A system and process for providing safety limits on the delivery of an infusion formulation by an infusion pump system in response to a sensed biological state. The safety limits may comprise user-initiated event signals corresponding to events that may significantly affect the biological state. The safety limits may further comprise user-initiated event ranking signals for respective events which specify a degree, quantity, or measure for the respective event. The user-initiated event and event ranking signals may be communicated to a computing element associated with the infusion pump by an associated communication device having a user interface which comprises a plurality of user-selectable operators for entering information about the events and event rankings.

423 citations