Journal ArticleDOI
Spectrum of candidate molecules against Chikungunya virus - an insight into the antiviral screening platforms
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TLDR
The greatest challenge being the non-availability of robust, reproducible, cost-effective and biologically accurate assay models, there is a need to identify good models mimicking the appropriate microenvironment of an infectious setting.Abstract:
Introduction: Chikungunya disease has undergone a phenomenal transition in its status from being recognized as a sporadic infection to acquiring a global prominence over the last couple of decades....read more
Citations
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Journal ArticleDOI
Arthritogenic Alphaviruses: A Worldwide Emerging Threat?
Laura I. Levi,Marco Vignuzzi +1 more
TL;DR: This review evaluates other arthritogenic alphaviruses that are as of yet restrained to specific territories are the cause of neglected tropical diseases and their emerging potential in light of the current knowledge for each and in comparison to chikungunya virus.
Journal ArticleDOI
Antiviral therapeutics for chikungunya virus
Ritu Ghildiyal,Reema Gabrani +1 more
TL;DR: This review provides an overview of the granted patents including the current status of antiviral strategies targeting CHIKV, a reemerging human arthropod borne virus, which has become a serious health concern due to the unavailability of any antiviral therapy/vaccine.
Book ChapterDOI
Small Molecule Inhibitors Targeting Chikungunya Virus.
TL;DR: The current status of small molecule inhibitor development against CHIKV is summarized and novel therapeutics that reduces viral loads should be developed to positively impact virus inflammatory disease and improve patient outcomes following CHikV infection.
Journal ArticleDOI
Antiviral drug research for Japanese encephalitis: an updated review
TL;DR: In this paper , a literature search was performed using databases such as PubMed Central, Google Scholar, Wiley Online Library, etc. using keywords such as Japanese encephalitis virus, antivirus drugs, antiviral drug screening, and antivirus drug targets, whereas 180 most relevant and important ones have been cited.
Journal ArticleDOI
Antiviral drug research for Japanese encephalitis: an updated review
TL;DR: In this paper , a literature search was performed using databases such as PubMed Central, Google Scholar, Wiley Online Library, etc. using keywords such as Japanese encephalitis virus, antivirus drugs, antiviral drug screening, and antivirus drug targets, whereas 180 most relevant and important ones have been cited.
References
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Journal ArticleDOI
Infection with chikungunya virus in Italy: an outbreak in a temperate region
Giovanni Rezza,Loredana Nicoletti,R Angelini,Roberto Romi,A C Finarelli,M. Panning,Paolo Cordioli,Claudia Fortuna,S. Boros,Fabio Magurano,G. Silvi,Paola Angelini,Michele Dottori,Maria Grazia Ciufolini,Giancarlo Majori,Antonio Cassone +15 more
TL;DR: In this article, an outbreak of chikungunya virus (CHIKV) was reported in Italy, where the primary source of infection and modes of transmission were identified and an active surveillance system was also implemented.
Journal ArticleDOI
A single mutation in chikungunya virus affects vector specificity and epidemic potential.
TL;DR: The observation that a single amino acid substitution can influence vector specificity provides a plausible explanation of how this mutant virus caused an epidemic in a region lacking the typical vector, and has important implications with respect to how viruses may establish a transmission cycle when introduced into a new area.
Journal ArticleDOI
RNA Interference: Biology, Mechanism, and Applications
Neema Agrawal,Palakodeti V.N. Dasaradhi,Asif Mohmmed,Pawan Malhotra,Raj K. Bhatnagar,Sunil K. Mukherjee +5 more
TL;DR: Because of its exquisite specificity and efficiency, RNAi is being considered as an important tool not only for functional genomics, but also for gene-specific therapeutic activities that target the mRNAs of disease-related genes.
Journal ArticleDOI
Impact of high-throughput screening in biomedical research
Ricardo Macarron,Martyn Banks,Dejan Bojanic,David J. Burns,Dragan A. Cirovic,Tina Garyantes,Darren V. S. Green,Robert P. Hertzberg,William P. Janzen,Jeff W. Paslay,Ulrich Schopfer,G. Sitta Sittampalam +11 more
TL;DR: The case for the use of HTS as part of a proven scientific tool kit, the wider use of which is essential for the discovery of new chemotypes is presented.
Journal ArticleDOI
Chikungunya, an epidemic arbovirosis.
TL;DR: Chikungunya is an arboviral disease transmitted by aedes mosquitoes and was first isolated in 1953 in Tanzania as mentioned in this paper, where it is a specifi cally tropical disease, but it is geographically restricted and outbreaks are relatively uncommon.
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