Spinal neurons specifically excited by noxious or thermal stimuli: marginal zone of the dorsal horn.
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2,566 citations
Cites background from "Spinal neurons specifically excited..."
...(2000) Spinal cord hemisection Christensen et al. (1996); Christensen & Hulsebosch (1997a, 1997b) Injection of quisqualic acid Yezierski & Park (1993); Yezierski et al. (1993, 1998) Injection of kainate LaBuda et al. (2000) Ischemia Hao, Xu, Yu, et al. (1991); Hao, Xu, Aldskogius, et al. (1991); Hao, Xu, Yu, et al. (1992); Xu et al. (1992); Hao, Xu, Aldskogius, et al....
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...The finding of the superficial laminae of the spinal cord for nociception demonstrated that these neurons responded to mechanical and thermal nociceptive inputs in lamina I (B. N. Christensen & Perl, 1970) and II (Kumazawa & Perl, 1978)....
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...(2000) Spinal cord hemisection Christensen et al. (1996); Christensen & Hulsebosch (1997a, 1997b) Injection of quisqualic acid Yezierski & Park (1993); Yezierski et al. (1993, 1998) Injection of kainate LaBuda et al. (2000) Ischemia Hao, Xu, Yu, et al. (1991); Hao, Xu, Aldskogius, et al. (1991); Hao, Xu, Yu, et al....
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...(2000) Spinal cord hemisection Christensen et al. (1996); Christensen & Hulsebosch (1997a, 1997b) Injection of quisqualic acid Yezierski & Park (1993); Yezierski et al. (1993, 1998) Injection of kainate LaBuda et al. (2000) Ischemia Hao, Xu, Yu, et al. (1991); Hao, Xu, Aldskogius, et al. (1991); Hao, Xu, Yu, et al. (1992); Xu et al. (1992); Hao, Xu, Aldskogius, et al. (1992) Sciatic Injection of zymosan Gazda et al. (2001); Chacur et al....
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...(2000) Spinal cord hemisection Christensen et al. (1996); Christensen & Hulsebosch (1997a, 1997b) Injection of quisqualic acid Yezierski & Park (1993); Yezierski et al. (1993, 1998) Injection of kainate LaBuda et al. (2000) Ischemia Hao, Xu, Yu, et al. (1991); Hao, Xu, Aldskogius, et al....
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955 citations
950 citations
Cites background from "Spinal neurons specifically excited..."
...Innocuous primary afferent (Aδ ‘cool’ and C ‘warm’) thermoreceptors innervating skin and deep tissues terminate in the superficial spinal (and trigeminal) dorsal horn, where a unique population of lamina I spinothalamic neurons is thermoreceptive-specific and morphologically distinc...
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867 citations
783 citations
References
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Additional excerpts
...These results were taken to indicate that the dorsal horn marginal layer, Rexed’s lamina I (20), represents a specialized sensory nucleus containing neurons important for nociception and for detection of thermal changes in the skin....
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1,022 citations
"Spinal neurons specifically excited..." refers background or methods in this paper
...Spinal units responding to strong mechanical stimuli and to noxious heat apparently received an excitatory input from both the high-threshold mechanoreceptors with myelinated afferent fibers (3) and the polymodal nociceptors with unmyelinated afferent fibers (1)....
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...for activation; apparently they were subject to convergence from both the high-threshold mechanoreceptors with myelinated fibers and polymodal nociceptors with unmyelinated fibers (1)....
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...Skin stimuli were delivered using the various devices described in previous publications (1, 3)....
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594 citations
"Spinal neurons specifically excited..." refers background or methods in this paper
...gested as part of the afferent apparatus for pain resulting from mechanical damage to the skin (3, 17)....
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...studies on the posterior femoral cutaneous and sural nerves (3, 4), some high-threshold mechanoreceptors may have receptive terminals distributed over as large an area as that innervated by a coccygeal segment....
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...One group responded in a way indicating an effective drive solely from the myelinated afferent fibers of high-threshold mechanoreceptors (3); they responded only to strong or frankly noxious mechanical stimulation of the skin....
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...Spinal units responding to strong mechanical stimuli and to noxious heat apparently received an excitatory input from both the high-threshold mechanoreceptors with myelinated afferent fibers (3) and the polymodal nociceptors with unmyelinated afferent fibers (1)....
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...Skin stimuli were delivered using the various devices described in previous publications (1, 3)....
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349 citations
315 citations
"Spinal neurons specifically excited..." refers background in this paper
...gested as part of the afferent apparatus for pain resulting from mechanical damage to the skin (3, 17)....
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