Splice variants of the N-methyl-D-aspartate receptor NR1 identify domains involved in regulation by polyamines and protein kinase C
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...Some phosphorylation sites responsible for the Mg21-independent PKC-induced potentiation in NR1 subunits lacking C1 (Durand et al., 1993; Wagner and Leonard, 1996) might lie within NR1 but outside of C1, or might instead reside in the Xenopus XenU1 subunit (Soloviev and Barnard, 1997)....
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...…without NR2 subunits in Xenopus oocytes but are more sensitive to block by Zn21 and protons when expressed with NR2 subunits, and show stronger potentiation by polyamines through relief of proton inhibition (see below; Durand et al., 1993; Hollmann et al., 1993; Traynelis et al., 1995, 1998)....
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...Receptors containing N1 without C1 and C2 are more strongly enhanced by phorbol esters than those with C1 or C2 (Durand et al., 1993)....
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...However, the C1 cassette does not seem to be responsible for PKC-induced potentiation, because recombinant homomeric NR1 receptors lacking the C1 cassette (NR12a) show even higher potentiation by PKC than receptors containing C1 (Durand et al., 1993)....
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