Splicing of Nascent RNA Coincides with Intron Exit from RNA Polymerase II.
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Cites background from "Splicing of Nascent RNA Coincides w..."
...At the same time, yet other studies document that transcriptional pausing is not observed when RNAP II transcribed past a normal 3′ splice site during linear splicing [102] raising the question whether the speed of elongation is indeed a physiological determinant in the antagonism between linear splicing and backsplicing....
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Cites background or methods from "Splicing of Nascent RNA Coincides w..."
...Seminal work in budding yeast using anti-pol II ChIP-seq strongly suggests that at a splicing-dependent transcriptional pause occurs at 3′ splice sites [20,63]; however, these pause sites have yet to be confirmed by nascent RNA sequencing [58]....
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...017 transcripts enriched by either high salt urea washing of chromatin [21,58] or anti-pol II immunoprecipitation [59]....
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...Recently, long-range sequencing of nascent transcripts from their 3′ ends revealed that in yeasts, co-transcriptional splicing can be completed by the time pol II has extended only 25–30 bases beyond the 3′ splice site [58]....
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