Journal ArticleDOI
Spontaneous death of Echinococcus multilocularis: cases diagnosed serologically (by Em2 ELISA) and clinical significance.
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TLDR
The findings show that the Em2 ELISA may be positive in patients having lesions of AHD in which the etiologic agent is no longer viable, in agreement with the clinical impression that the cestode was dead.Abstract:
Nine cases of asymptomatic alveolar hydatid disease (AHD) of the liver were diagnosed in 1985 among Eskimos from the endemic region of western Alaska. The patients were identified by screening with the enzyme-linked immunosorbent assay, using purified Echinococcus multilocularis antigen (Em2 ELISA). Five patients, and one diagnosed earlier (1979), were found to have lesions in which the larval E. multilocularis had died spontaneously at an early stage of infection. Viability was assessed histologically; by the avidinbiotin immunohistochemical method; and in vivo through intraperitoneal inoculation of membranes of the larval cestode into red-backed voles, Clethrionomys rutilus. The results were in agreement with the clinical impression, based on findings by computerized tomography and ultrasound scanning, and on the macroscopic appearance of the lesions, that the cestode was dead. Spontaneous death of E. multilocularis in humans has not been previously reported. The findings show that the Em2 ELISA may be positive in patients having lesions of AHD in which the etiologic agent is no longer viable.read more
Citations
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Journal ArticleDOI
Biological, Epidemiological, and Clinical Aspects of Echinococcosis, a Zoonosis of Increasing Concern
Johannes Eckert,Peter Deplazes +1 more
TL;DR: Various aspects of human echinococcosis are discussed in this review, including data on the infectivity of genetic variants of E. granulosus to humans, the increasing invasion of cities in Europe and Japan by red foxes, the main definitive hosts ofE.
Journal ArticleDOI
Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans
TL;DR: Advances in classification and treatment of echinococcosis prompted experts from different continents to review the current literature, discuss recent achievements and provide a consensus on diagnosis, treatment and follow-up.
Journal ArticleDOI
European echinococcosis registry: human alveolar echinococcosis, Europe, 1982-2000.
TL;DR: The increasing prevalence of Echinococcus multilocularis in foxes in rural and urban areas of central Europe and the occurrence of cases outside the alveolar echinococcosis–endemic regions suggest that this disease deserves increased attention.
Book ChapterDOI
The Echinococcoses: Diagnosis, Clinical Management and Burden of Disease.
Peter Kern,A Menezes da Silva,Okan Akhan,Beat Müllhaupt,K A Vizcaychipi,Christine M. Budke,Dominique A. Vuitton +6 more
TL;DR: A structured stage-specific approach to CE management, based on the World Health Organization ultrasound classification of liver cysts, is now recommended, and includes WHO staging, drug therapy and long-term follow-up for at least a decade.
Journal ArticleDOI
Hepatic echinococcosis: Clinical and therapeutic aspects
Giuseppe Nunnari,Marilia Rita Pinzone,Salvatore Gruttadauria,Benedetto Maurizio Celesia,Giordano Madeddu,Giulia Malaguarnera,Piero Pavone,Alessandro Cappellani,Bruno Cacopardo +8 more
TL;DR: The improvement of surgical techniques, the introduction of minimally invasive treatments and more effective drugs have deeply changed life expectancy and quality of life of patients with HD.