SRC-3 Coactivator Governs Dynamic Estrogen-Induced Chromatin Looping Interactions during Transcription
Anil K. Panigrahi,Charles E. Foulds,Rainer B. Lanz,Ross A. Hamilton,Ping Yi,David M. Lonard,Ming-Jer Tsai,Sophia Y. Tsai,Bert W. O'Malley +8 more
Reads0
Chats0
TLDR
It is demonstrated that EPC is linked to mutually stimulatory transcription at the enhancer and promoter in vitro and SRC-3 was identified as a critical looping determinant for the estradiol-(E2)-regulated GREB1 locus.About:
This article is published in Molecular Cell.The article was published on 2018-05-17 and is currently open access. It has received 32 citations till now. The article focuses on the topics: Enhancer & Promoter.read more
Citations
More filters
YY1 Is a Structural Regulator of Enhancer-Promoter Loops
Alla A. Sigova,Nancy M. Hannett,Daniel S. Day,Brian J. Abraham,Malkiel A. Cohen,Behnam Nabet,Dennis L. Buckley,Yang Eric Guo,Denes Hnisz,James E. Bradner,Nathanael S. Gray,Abraham S. Weintraub,Charles H. Li,Alicia Zamudio Montes de Oca,Rudolf Jaenisch,Richard A. Young +15 more
TL;DR: In this paper, the ubiquitously expressed transcription factor Yin Yang 1 (YY1) contributes to enhancer-promoter structural interactions in a manner analogous to DNA interactions mediated by CTCF.
Journal ArticleDOI
Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer.
David A. Bader,Sean M. Hartig,Vasanta Putluri,Christopher Foley,Mark P. Hamilton,Eric A. Smith,Pradip K. Saha,Anil K. Panigrahi,Christopher M. Walker,Lin Zong,Heidi Martini-Stoica,Rui Chen,Kimal Rajapakshe,Cristian Coarfa,Arun Sreekumar,Nicholas Mitsiades,James A. Bankson,Michael Ittmann,Bert W. O'Malley,Nagireddy Putluri,Sean E. McGuire,Sean E. McGuire +21 more
TL;DR: The authors demonstrate that the mitochondrial pyruvate carrier (MPC), a critical metabolic conduit linking cytosolic and mitochondrial metabolism, is transcriptionally regulated by AR and that MPC inhibition suppresses tumour growth in hormone-responsive and castrate-resistant conditions.
Journal ArticleDOI
Mechanisms of enhancer action: the known and the unknown
TL;DR: A key regulator of differential gene expression programs are the enhancers, the gene-distal cis-regulatory sequences that govern spatiotemporal and quantitative expression dynamics of target genes.
Journal ArticleDOI
Structural Insights of Transcriptionally Active, Full-Length Androgen Receptor Coactivator Complexes
Xinzhe Yu,Ping Yi,Ross A. Hamilton,Hong Shen,Muyuan Chen,Charles E. Foulds,Michael A. Mancini,Steven J. Ludtke,Zhao Wang,Bert W. O'Malley +9 more
TL;DR: Cryoelectron microscopy structures of DNA-bound full-length AR and its complex structure with key coactivators, SRC-3 and p300 are presented and provide a basis for understanding assembly of the AR:coactivator complex and its domain contributions for coactivator assembly and transcriptional regulation.
Journal ArticleDOI
NET-CAGE characterizes the dynamics and topology of human transcribed cis-regulatory elements
Shigeki Hirabayashi,Shruti Bhagat,Yu Matsuki,Yujiro Takegami,Takuya Uehata,Takuya Uehata,Ai Kanemaru,Masayoshi Itoh,Kotaro Shirakawa,Akifumi Takaori-Kondo,Osamu Takeuchi,Osamu Takeuchi,Piero Carninci,Shintaro Katayama,Yoshihide Hayashizaki,Juha Kere,Hideya Kawaji,Yasuhiro Murakawa +17 more
TL;DR: A simple and robust method, native elongating transcript–cap analysis of gene expression (NET-CAGE), to sensitively detect 5′ ends of nascent RNAs in diverse cells and tissues, including unstable transcripts such as enhancer-derived RNAs, and shows that enhancer–promoter pairs are generally activated simultaneously.
References
More filters
Journal ArticleDOI
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
TL;DR: A procedure for preparing extracts from nuclei of human tissue culture cells that directs accurate transcription initiation in vitro from class II promoters, including tRNA and Ad 2 VA, is developed.
Journal ArticleDOI
A unique chromatin signature uncovers early developmental enhancers in humans
Alvaro Rada-Iglesias,Ruchi Bajpai,Tomek Swigut,Samantha A. Brugmann,Ryan A. Flynn,Joanna Wysocka +5 more
TL;DR: It is demonstrated that early developmental enhancers are epigenetically pre-marked in hESCs and indicate an unappreciated role of H3K27me3 at distal regulatory elements.
Journal ArticleDOI
Transcription factors: from enhancer binding to developmental control.
TL;DR: Current knowledge of transcription factor function from genomic and genetic studies is reviewed and how different strategies, including extensive cooperative regulation, progressive priming of regulatory elements, and the integration of activities from multiple enhancers, confer specificity and robustness to transcriptional regulation during development are discussed.
Mediator and cohesin connect gene expression and chromatin architecture
Michael H. Kagey,Jamie J. Newman,Steve Bilodeau,Ye Zhan,David A. Orlando,Nynke L. van Berkum,Christopher C. Ebmeier,Jesse Goossens,Peter B. Rahl,Stuart S. Levine,Dylan J. Taatjes,Job Dekker,Richard A. Young +12 more
TL;DR: It is reported that mediator and cohesin physically and functionally connect the enhancers and core promoters of active genes in murine embryonic stem cells.
Journal ArticleDOI
Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription.
TL;DR: It is shown that recruitment of the p160 class of coactivators is sufficient for gene activation and for the growth stimulatory actions of estrogen in breast cancer supporting a model in which ER cofactors play unique roles in estrogen signaling.
Related Papers (5)
Widespread transcription at neuronal activity-regulated enhancers
Tae Kyung Kim,Martin Hemberg,Jesse M. Gray,Allen M. Costa,Daniel M. Bear,Jing Wu,David A. Harmin,Michael W. Laptewicz,Kellie Barbara-Haley,Scott Kuersten,Eirene Markenscoff-Papadimitriou,Eirene Markenscoff-Papadimitriou,Dietmar Kuhl,Haruhiko Bito,Paul F. Worley,Gabriel Kreiman,Michael E. Greenberg +16 more
An atlas of active enhancers across human cell types and tissues
Robin Andersson,Claudia Gebhard,Irene Miguel-Escalada,Ilka Hoof,Jette Bornholdt,Mette Boyd,Yun Chen,Xiaobei Zhao,Xiaobei Zhao,Christian Schmidl,Takahiro Suzuki,Evgenia Ntini,Erik Arner,Eivind Valen,Eivind Valen,Kang Li,Lucia Schwarzfischer,Dagmar Glatz,Johanna Raithel,Berit Lilje,Nicolas Rapin,Frederik Otzen Bagger,Mette Rose Jørgensen,Peter Refsing Andersen,Nicolas Bertin,Owen J. L. Rackham,A. Maxwell Burroughs,J Kenneth Baillie,Yuri Ishizu,Yuri Shimizu,Erina Furuhata,Shiori Maeda,Yutaka Negishi,Christopher J. Mungall,Terrence F. Meehan,Timo Lassmann,Masayoshi Itoh,Hideya Kawaji,Naoto Kondo,Jun Kawai,Andreas Lennartsson,Carsten O. Daub,Peter Heutink,David A. Hume,Torben Heick Jensen,Harukazu Suzuki,Yoshihide Hayashizaki,Ferenc Müller,Alistair R. R. Forrest,Piero Carninci,Michael Rehli,Albin Sandelin +51 more