SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
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Cites result from "SREBPs: activators of the complete ..."
...Given previous observations of higher fed-state DNL (23) and the known stimulatory effect of insulin on fatty acid synthesis (24), we were surprised that fed-state lipogenesis assessed at 1500 in tTRL TAG did not differ from values obtained in the fasting Figure 1 Model of lipid flux through the liver....
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...In the nucleus, SREBP-1c transcriptionally activates all genes required for lipogenesis (15, 23)....
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...which also can be desaturated to form oleic acid (C18:1) (15)....
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References
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"SREBPs: activators of the complete ..." refers background in this paper
...Metformin stimulates AMP-activated protein kinase (AMPK), an enzyme that inhibits lipid synthesis through phosphorylation and inactivation of key lipogenic enzymes (41)....
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...In rat hepatocytes, metformin-induced activation of AMPK also leads to decreased mRNA expression of SREBP-1c and its lipogenic target genes (41), but the basis of this effect is not understood....
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"SREBPs: activators of the complete ..." refers background in this paper
...SREBPs in disease Many individuals with obesity and insulin resistance also have fatty livers, one of the most commonly encountered liver abnormalities in the US (37)....
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"SREBPs: activators of the complete ..." refers background in this paper
...This form of regulation is manifest not only in cultured cells (1), but also in the livers of rodents fed cholesterol-enriched diets (19)....
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...SREBPs stimulate LDL receptor expression, but they also enhance lipid synthesis (1), so their net effect on plasma lipoprotein levels depends on a balance between opposing effects....
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...2 through the use of alternative transcription start sites that produce alternate forms of exon 1, designated 1a and 1c (1)....
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...bound to the endoplasmic reticulum (ER) (1, 5)....
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...The net result is that SREBPs lose their access to S1P and S2P in the Golgi apparatus, so their bHLH-Zip domains cannot be released from the ER membrane, and the transcription of target genes ceases (1, 5)....
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2,367 citations