Stability of curcumin in buffer solutions and characterization of its degradation products
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Cites background from "Stability of curcumin in buffer sol..."
...[15] Wang YJ, Pan MH, Cheng AL, Lin LI, Ho YS, Hsieh CY, et al....
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...016 containing 10% fetal calf serum and in human blood, <20% of curcumin being degraded within 1 h and approximately 50% by 8 h [15]....
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...Degradation of curcumin is extremely slow at pH 1–6 [15], as normally encountered in the stomach....
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Cites background from "Stability of curcumin in buffer sol..."
...The bis-keto form predominates in acidic and neutral aqueous solutions and in the cell membrane [8]....
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...The presence of foetal calf serum or human blood, or addition of antioxidants such as ascorbic acid, N-acetylcysteine or glutathione, completely blocks this degradation in culture media or phosphate buffer above pH 7 [8]....
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...Other investigators have also found that curcumin is more stable in cell culture medium containing 10% foetal calf serum or in human blood, with less that 20% decomposition within 1 h compared to 90% within 30 min in serum-free medium [8]....
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...Under acidic conditions, the degradation of curcumin is much slower, with less than 20% of total curcumin decomposed at 1 h [8]....
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