State of the art of self-etch adhesives

doi:10.1016/J.DENTAL.2010.10.023

Home
/
Papers
/
State of the art of self-etch adhesives

Journal Article•DOI•

State of the art of self-etch adhesives

B. Van Meerbeek¹, Kumiko Yoshihara¹, Yasuhiro Yoshida², Atsushi Mine², J. De Munck¹, K.L. Van Landuyt¹ - Show less +2 more•Institutions (2)

Catholic University of Leuven¹, Okayama University²

01 Jan 2011-Dental Materials (Elsevier)-Vol. 27, Iss: 1, pp 17-28

TL;DR: The major shortcomings of the most simple-to-use one-step (self-etch) adhesives are addressed and special attention is devoted to the AD-concept and the benefit of chemical interfacial interaction with regard to bond durability.

read less

About: This article is published in Dental Materials.The article was published on 2011-01-01. It has received 1059 citations till now.

...read moreread less

Citations

PDF

Open Access

More filters

Journal Article•DOI•

Progress in dimethacrylate-based dental composite technology and curing efficiency

[...]

Julian Leprince¹, William M. Palin², Mohammed A. Hadis², Jacques Devaux¹, Gaëtane Leloup¹ - Show less +1 more•Institutions (2)

Université catholique de Louvain¹, University of Birmingham²

01 Feb 2013-Dental Materials

TL;DR: A review of the key factors affecting the polymerization efficiency of light-activated resin-based composites highlights the apparent need for a more informative approach by manufacturers to relay appropriate information in order to optimize material properties of resin composites used in daily practice.

...read moreread less

426 citations

Cites background from "State of the art of self-etch adhes..."

...Such trends are due affinity with tooth tissue [2]....
[...]
...[2] Van Meerbeek B, Yoshihara K, Yoshida Y, Mine A, De Munck J, Van Landuyt KL....
[...]

Journal Article•DOI•

Bond strength of universal adhesives: A systematic review and meta-analysis.

[...]

Wellington Luiz de Oliveira da Rosa¹, Evandro Piva¹, Adriana Fernandes da Silva¹•Institutions (1)

Universidade Federal de Pelotas¹

01 Jul 2015-Journal of Dentistry

TL;DR: The enamel bond strength of universal adhesives is improved with prior phosphoric acid etching, however, this effect was not evident for dentin with the use of mild universalAdhesives with the etch-and-rinse strategy.

...read moreread less

400 citations

Cites background or methods from "State of the art of self-etch adhes..."

...8,9 Thus, these adhesives are easy-to-use, have a faster application procedure and are less susceptible of differences in the operator’s technique when compared with multi-step etch-and-rinse adhesives.(1,10)...
[...]
...On the other hand, self-etch adhesives contain acid resin monomers that simultaneously “condition” and “prime” the dental substrates and do not require a prior phosphoric acid etching step.(1) These types of adhesive only dissolve the smear layer and do not remove the dissolved calcium phosphates....
[...]
..., sound, carious, sclerotic dentin, as well as enamel).(1) Considering the differences in professional judgment regarding the selection of the adhesive...
[...]
...The etch-and-rinse strategy involves the prior application of phosphoric acid, which, at enamel, produces deep etch-pits in the hydroxyapatite (HAp)-rich substrate and, at dentin, demineralizes up to a depth of a few micrometers to expose an HAp-deprived collagen mesh.(1,3) Thus, etch-and-rinse adhesives are available for use in three steps (acid etching, primer and adhesive) or two steps (primer and adhesive joined into one single material)....
[...]
...On dentin, this process is called ‘hybridization’ and involves the formation of the hybrid layer that contain with resin-infiltrated collagen fibrils.(1,2) Phosphoric acid etching (30-40%) of dentin promotes superficial dentin demineralization and collaborates in the removal of the smear layer, leading to the exposure of the collagen fibrils....
[...]

Journal Article•DOI•

Strategies to prevent hydrolytic degradation of the hybrid layer—A review

[...]

Leo Tjäderhane¹, Fabio D. Nascimento, Lorenzo Breschi², Annalisa Mazzoni², Ivarne L.S. Tersariol³, Ivarne L.S. Tersariol⁴, Saulo Geraldeli⁵, Arzu Tezvergil-Mutluay⁶, Marcela Carrilho⁷, Ricardo M. Carvalho⁸, Franklin R. Tay⁹, David H. Pashley⁹ - Show less +8 more•Institutions (9)

Oulu University Hospital¹, University of Trieste², Universidade de Mogi das Cruzes³, Federal University of São Paulo⁴, University of Florida⁵, University of Turku⁶, University of Western Ontario⁷, University of British Columbia⁸, Georgia Regents University⁹

01 Oct 2013-Dental Materials

TL;DR: This review will examine both the principles and outcomes of techniques to prevent collagen hydrolysis in dentin-resin interfaces, and shows that enzyme inhibition is a promising approach to improve hybrid layer preservation and bond strength durability.

...read moreread less

332 citations

Cites background from "State of the art of self-etch adhes..."

...[83] Van Meerbeek B, Yoshihara K, Yoshida Y, Mine A, De Munck J, Van Landuyt KL....
[...]
...Even though the concept of chemical bonding with SE adhesives to dentin hydroxyapatite is, in a strict sense, not aiming to inhibit dentin enzymatic function, it has been suggested to preserve the long-term collagen integrity in the hybrid layer [83]....
[...]
...016 believed to minimize nanoleakage, leave a substantial amount of hydroxyapatite around the collagen fibrils to mask the collagen cleavage site and keep the enzymes “fossilized” [83]....
[...]

Journal Article•DOI•

Self-assembled Nano-layering at the Adhesive Interface

[...]

Yasuhiro Yoshida¹, Kumiko Yoshihara², Noriyuki Nagaoka¹, Satoshi Hayakawa¹, Yasuhiro Torii¹, Tatsuyuki Ogawa¹, Akiyoshi Osaka¹, B. Van Meerbeek² - Show less +4 more•Institutions (2)

Okayama University¹, Katholieke Universiteit Leuven²

01 Feb 2012-Journal of Dental Research

TL;DR: Describing adhesive-dentin interfaces chemically and ultrastructurally revealed nano-layering at the adhesive interface, not only within the hybrid layer but also, particularly for Clearfil SE Bond (Kuraray), extending into the adhesive layer.

...read moreread less

Abstract: According to the 'Adhesion-Decalcification' concept, specific functional monomers within dental adhesives can ionically interact with hydroxyapatite (HAp). Such ionic bonding has been demonstrated for 10-methacryloyloxydecyl dihydrogen phosphate (MDP) to manifest in the form of self-assembled 'nano-layering'. However, it remained to be explored if such nano-layering also occurs on tooth tissue when commercial MDP-containing adhesives (Clearfil SE Bond, Kuraray; Scotchbond Universal, 3M ESPE) were applied following common clinical application protocols. We therefore characterized adhesive-dentin interfaces chemically, using x-ray diffraction (XRD) and energy-dispersive x-ray spectroscopy (EDS), and ultrastructurally, using (scanning) transmission electron microscopy (TEM/STEM). Both adhesives revealed nano-layering at the adhesive interface, not only within the hybrid layer but also, particularly for Clearfil SE Bond (Kuraray), extending into the adhesive layer. Since such self-assembled nano-layering of two 10-MDP molecules, joined by stable MDP-Ca salt formation, must make the adhesive interface more resistant to biodegradation, it may well explain the documented favorable clinical longevity of bonds produced by 10-MDP-based adhesives.

...read moreread less

308 citations

Cites background or result from "State of the art of self-etch adhes..."

...This finding favors the use of a ‘mild’ self-etch rather than an ‘etch-and-rinse’ approach with dentin (Van Meerbeek et al., 2011)....
[...]
...Selectively etching enamel combined with a ‘mild’ self-etch adhesive can therefore today be recommended to achieve effective and durable bonding to tooth enamel and dentin (Van Meerbeek et al., 2011)....
[...]

Journal Article•DOI•

Dentin bonding systems: From dentin collagen structure to bond preservation and clinical applications

[...]

Lorenzo Breschi¹, Tatjana Maravic², Sandra Ribeiro Cunha³, Allegra Comba¹, Milena Cadenaro⁴, Leo Tjäderhane⁵, David H. Pashley⁶, Franklin R. Tay⁶, Annalisa Mazzoni¹ - Show less +5 more•Institutions (6)

University of Bologna¹, University of Novi Sad², University of São Paulo³, University of Trieste⁴, Oulu University Hospital⁵, Georgia Regents University⁶

01 Jan 2018-Dental Materials

TL;DR: This study critically discusses the available peer-reviewed research concerning the formation and preservation of the hybrid layer (HL), the mechanisms that lead to the degradation of the HL as well as the strategies to prevent it.

...read moreread less

261 citations

Cites background from "State of the art of self-etch adhes..."

...[5] Van Meerbeek B, Yoshihara K, Yoshida Y, Mine A, De Munck J, Van Landuyt KL....
[...]

1
2
3
4
…
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200

Collapse

References

PDF

Open Access

More filters

Journal Article•DOI•

Buonocore Memorial Lecture

[...]

Jacques E. Nör¹•Institutions (1)

University of Michigan¹

01 Nov 2006

TL;DR: This review is focused on the presentation and discussion of existing literature that covers theengineering of enamel, dentin and pulp, as well on the engineering of entire teeth.

...read moreread less

Abstract: For many years, operative dentistry has been using regenerative approaches to treat dental disease. The use of calcium hydroxide to stimulate reparative or reactionary dentin is clearly an example of such a therapeutic strategy. The advent of tissue engineering is allowing dentistry to move forward in the use of regeneration as an underlying principle for the treatment of dental disease. Tissue engineering is a multi-disciplinary science that brings together biology, engineering and clinical sciences with developing new tissues and organs. It is based on fundamental principles that involve the identification of appropriate cells, the development of conducive scaffolds and an understanding of the morphogenic signals required to induce cells to regenerate the tissues that were lost. This review is focused on the presentation and discussion of existing literature that covers the engineering of enamel, dentin and pulp, as well on the engineering of entire teeth. There are clearly major roadblocks to ...

...read moreread less

517 citations

Journal Article•DOI•

Evidence of Chemical Bonding at Biomaterial-Hard Tissue Interfaces:

[...]

Yasuhiro Yoshida¹, B. Van Meerbeek², Y. Nakayama³, J. Snauwaert², L. Hellemans², Paul Lambrechts², Guido Vanherle², Kunio Wakasa¹ - Show less +4 more•Institutions (3)

Hiroshima University¹, Catholic University of Leuven², National Space Development Agency of Japan³

01 Feb 2000-Journal of Dental Research

TL;DR: It is concluded that an ultrathin layer of a polyalkenoic acid can be prepared on a hydroxyapatite-based substrate by careful removal of non-bonded molecules.

...read moreread less

Abstract: For many years, glass-polyalkenoate cements have been described as possessing the unique properties of self-adherence to human hard tissues, such as bones or teeth. However, direct experimental evidence to prove the existence of chemical bonding has not been advanced. X-ray Photoelectron Spectroscopy (XPS) was used to analyze the chemical interaction of a synthesized polyalkenoic acid with enamel and synthetic hydroxyapatite. For both enamel and hydroxyapatite, the peak representing the carboxyl groups of the polyalkenoic acid was detected to have significantly shifted to a lower binding energy. De-convolution of this shifted peak disclosed two components with a peak representing unreacted carboxyl groups and a peak suggesting chemical bonding to hydroxyapatite. On average, 67.5% of the carboxyl groups of the polyalkenoic acid were measured to have bonded to hydroxyapatite. XPS of hydroxyapatite also disclosed its surface to be enriched in calcium and decreased in phosphorus, indicating that phosphorus was extracted at a relatively higher rate than calcium. Analysis of these data supports the mechanism in which carboxylic groups replace phosphate ions (PO4(3-)) of the substrate and make ionic bonds with calcium ions of hydroxyapatite. It is concluded that an ultrathin layer of a polyalkenoic acid can be prepared on a hydroxyapatite-based substrate by careful removal of non-bonded molecules. With this specimen-processing method, XPS not only provided direct evidence of chemical bonding, but also enabled us to quantify the percentages of functional groups of the polyalkenoic acids that bonded to calcium of hydroxyapatite.

...read moreread less

461 citations

"State of the art of self-etch adhes..." refers background in this paper

...micro-mechanical interlocking is a prerequisite to achieve good bonding (certainly within clinical circumstances), the potential benefit of additional chemical interaction between functional monomers and tooth substrate components has recently regained attention [28,29]....
[...]
...These data coroborate the AD-concept [30,31], and should be attributed to he low hydrolytic stability of the embedded calcium phoshates, along with the lack of stable chemical interaction with he exposed collagen....
[...]
...As mentioned before, this chemical interfacial interaction of 10-MDP corresponds to the ‘AD-concept PHASE 2, OPTION 1 (or 2.1)’ profile, but contrasts to that of phenyl-P that readily resulted in DCPD deposition, confirming the ‘ADconcept PHASE 2, OPTION 2 (or 2.2)’ profile of phenyl-P....
[...]
...According to the D-concept [28,30], polyalkenoic acid is a polymer with a mulitude of carboxyl functional groups that as chemical ‘hands’ rab individual Ca-ions along the mineral substrate....
[...]
...Confirming these experimental chemical data (and hence the AD-concept [30,31]), the bond strength to dentin of the 10-MDP-based ‘mild’ two-step self-etch adhesive Clearfil SE (Kuraray) remained high after long-term thermo-cycling, while that of Unifil Bond (GC) that contains 4-MET, sig- 22 d e n t a l m a t e r i a l s 2 7 ( 2 0 1 1 ) 17–28 ally -reso was associated with more substantial/rapid DCPD deposition, nificantly dropped (but only after 100,000 cycles) and that of Clearfil Liner Bond II (Kuraray) that contains phenyl-P, gradually decreased the longer the bond was exposed to thermo-cycling [46]....
[...]

Journal Article•DOI•

Monomer-Solvent Phase Separation in One-step Self-etch Adhesives

[...]

K.L. Van Landuyt¹, J. De Munck, Johan Snauwaert, Eduardo Coutinho, André Poitevin, Yasuhiro Yoshida, Satoshi Inoue, Marleen Peumans, Kazuomi Suzuki, Paul Lambrechts, B. Van Meerbeek - Show less +7 more•Institutions (1)

Catholic University of Leuven¹

01 Feb 2005-Journal of Dental Research

TL;DR: The prompt disappearance ofDroplets upon application of a small amount of HEMA (2-hydroxyethyl methacrylate) or a HEMA-containing bonding agent, as well as the absence of droplets at the interface of all HEMA -containing adhesives, strongly suggests that the adhesive monomers separate from water upon evaporation of ethanol/acetone.

...read moreread less

Abstract: One-step adhesives bond less effectively to enamel/dentin than do their multi-step versions. To investigate whether this might be due to phase separation between adhesive ingredients, we characterized the interaction of 5 experimental and 3 commercial self-etch adhesives with dentin using transmission electron microscopy. All adhesives were examined for homogeneity by light microscopy. Bonding effectiveness to dentin was determined with the use of a micro-tensile bond-strength protocol. The lower bond strength of the one-step adhesives was associated with light-microscopic observation of multiple droplets that disappeared slowly. Interfacial analysis confirmed the entrapment of droplets within the adhesive layer. The prompt disappearance of droplets upon application of a small amount of HEMA (2-hydroxyethyl methacrylate) or a HEMA-containing bonding agent, as well as the absence of droplets at the interface of all HEMA-containing adhesives, strongly suggests that the adhesive monomers separate from water upon evaporation of ethanol/acetone. Upon polymerization, the droplets become entrapped within the adhesive, potentially jeopardizing bond durability. This can be avoided by strong air-drying of the adhesive, thereby removing interfacial water and thus improving bonding effectiveness.

...read moreread less

383 citations

"State of the art of self-etch adhes..." refers background in this paper

...On the other hand, typical is also the phaseseparation described for HEMA-free/poor adhesives [23]....
[...]
...[23] Van Landuyt K, De Munck J, Snauwaert J, Coutinho E, Poitevin A, Yoshida Y, et al....
[...]

Journal Article•DOI•

Technique-sensitivity of Contemporary Adhesives

[...]

Bart Van Meerbeek¹, Kirsten Van Landuyt¹, Jan De Munck¹, Masanori Hashimoto², Masanori Hashimoto¹, Marleen Peumans¹, Paul Lambrechts¹, Yasuhiro Yoshida³, Satoshi Inoue², Kazuomi Suzuki³ - Show less +6 more•Institutions (3)

Catholic University of Leuven¹, Hokkaido University², Okayama University³

01 Mar 2005-Dental Materials Journal

TL;DR: Besides micro-mechanical interlocking through hybrid-layer formation, self-etch adhesives may benefit from additional chemical interaction between the functional monomer and residual hydroxyapatite, which may account for their lower bonding effectiveness.

...read moreread less

Abstract: Besides micro-mechanical interlocking through hybrid-layer formation, self-etch adhesives may benefit from additional chemical interaction between the functional monomer and residual hydroxyapatite. One-step adhesives are commonly associated with lower bonding effectiveness, which must be attributed in part to the dissolution of hydrophilic and hydrophobic monomers in a relatively highly concentrated solvent. In this 'difficult' mixture, also water is essential as ionization medium to enable self-etching activity. Due to the high hydrophilicity, one-step self-etch adhesives have been reported to behave as semi-permeable membranes, allowing fluids to pass through and seriously jeopardizing bond durability. Recent research has also revealed that HEMA-free one-step adhesives are prone to phase-separation, which may also account for their lower bonding effectiveness. Employing an appropriate air-drying technique may, however, improve the bonding effectiveness of such phase-separating adhesives by getting rid of substantially more interfacial water than HEMA-containing adhesives, of which water might be more difficult to remove from.

...read moreread less

335 citations

"State of the art of self-etch adhes..." refers background in this paper

...[16] Van Meerbeek B, Van Landuyt K, De Munck J, Hashimoto M, Peumans M, Lambrechts P, et al....
[...]

Journal Article•

How can nanoleakage occur in self-etching adhesive systems that demineralize and infiltrate simultaneously?

[...]

Franklin R. Tay¹, Nigel M. King¹, Kar Mun Chan¹, David H. Pashley²•Institutions (2)

University of Hong Kong¹, Georgia Regents University²

01 Jan 2002-Journal of Adhesive Dentistry

TL;DR: Silver uptake in hybrid layers formed by self-etching adhesives in sound dentin is not necessarily caused by disparities between the depths of demineralization and resin infiltration, and represents areas of increased permeability within a polymerized resin matrix.

...read moreread less

Abstract: PURPOSE Single-step adhesives which etch and prime simultaneously and are not rinsed should not exhibit areas of incomplete infiltration within hybrid layers produced in sound dentin. This study examined the extent of silver uptake using ammoniacal silver nitrate in three two-step, self-etching primers (Imperva Fluoro Bond, Shofu; UniFil Bond, GC, ABF system, Kuraray) and one single-step, self-etching adhesive (AQ Bond, Sun Medical) bonded to dentin and four poly(HEMA) resins used as controls. MATERIALS AND METHODS Flat dentin surfaces were bonded with these adhesives and sectioned into 0.8-mm-thick slabs that were then coated with nail varnish except for the bonded interfaces and immersed in AgNO3 for 24 h. Four types of poly(HEMA) resins were made: 100% HEMA; 90% HEMA-10% water; 75% HEMA-10% water, all polymerized with TBBO at 50 degrees C for 6 h; 100% HEMA polymerized at 25 degrees C for 30 min. After developing, undemineralized, unstained, epoxy resin-embedded sections were prepared for TEM. RESULTS Nanoleakage patterns were observed in all bonded specimens. Fine segregated silver particles and reticular silver-staining patterns were found within the thin hybrid layers created by the three self-etching primers. For the single-step, self-etching adhesive, heavy silver deposits were identified within the hybridized complex formed by this adhesive within the smear layer, the underlying intact dentin, and in the adhesive layer. Increasing amounts of silver uptake were observed in poly(HEMA) specimens containing more water or that were polymerized at 25 degrees C for a short time instead of 50 degrees C for 6 h. CONCLUSIONS Silver uptake in hybrid layers formed by self-etching adhesives in sound dentin is not necessarily caused by disparities between the depths of demineralization and resin infiltration. They represent areas of increased permeability within a polymerized resin matrix in which water is incompletely removed resulting in regions of incomplete polymerization and/or hydrogel formation.

...read moreread less

312 citations