Statins, antidiabetic medications and liver histology in patients with diabetes with non-alcoholic fatty liver disease.
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...Consistently, lonitudinal studies showed that NAFLD was associated with increased Disease 49 (2017) 471–483 475 burden of hepatic and extra-hepatic cancers [136] and malignancy was a leading cause of mortality in patients with NAFLD, ranking second after CVD mortality [137] and accounting for up to one third of deaths in patients with NAFLD and T2DM [138]....
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...%) are maximally prone to NAFLD evelopment; NAFLD is equally prevalent in either sex among atients with T2DM which, therefore, abrogates the higher prevaence of the male sex typically observed in non-diabetic NAFLD ndividuals [63]....
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...Statins seem also to exert some beneficial effect on liver fibrosis progression in patients with and without T2DM [96,97]....
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...Future controlled intervention trials are, thereore, needed to determine whether treating NAFLD leads to T2DM isk reduction....
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...In particular, the coexistence of T2DM and steatosis d Liver s fi 3 w e i c s P d H 3 d i r a o l t o o r G N a [ a v c n i p a i 1 h “ b r d [ t o i 5 s c o f r 3 d w t i g Position Paper / Digestive an trongly predicts the development of clinically significant hepatic brosis [100]....
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"Statins, antidiabetic medications a..." refers methods in this paper
...metabolic syndrome (MS) was defined according to the IDF criteria.(21) All liver biopsies were adequate in terms of length, absence of fragmentation and quality of staining with H&E and Picrosirius Hemalun....
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"Statins, antidiabetic medications a..." refers methods in this paper
...NASH was diagnosed when steatosis, lobular inflammation and hepatocellular ballooning were present, according to the FLIP algorithm.22 Fibrosis was staged according to Kleiner’s criteria and significant fibrosis was defined as ≥F2....
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...Fibrosis was staged according to Kleiner’s criteria and significant fibrosis was defined as ≥F2.(23) All patients provided informed consent for performing liver biopsy....
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