Journal ArticleDOI
Stem cell fate and patterning in mammalian epidermis.
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Stem cells exhibit a high degree of spatial organisation, and cell clustering and motility contribute to the assembly and maintenance of the epidermis.About:
This article is published in Current Opinion in Genetics & Development.The article was published on 2001-08-01. It has received 245 citations till now. The article focuses on the topics: Adult stem cell & Stem cell.read more
Citations
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Cancer Stem Cells: Models and Concepts
TL;DR: The biological basis and the therapeutic implications of the stem cell model of cancer, first developed in human myeloid leukemias, is reviewed, which is today being extended to solid tumors, such as breast and brain cancer.
Journal ArticleDOI
Capturing and profiling adult hair follicle stem cells
Rebecca J. Morris,Yaping Liu,Lee Marles,Zaixin Yang,Carol S. Trempus,Shulan Li,Jamie S. Lin,Janet A. Sawicki,George Cotsarelis +8 more
TL;DR: It is shown that bulge cells in adult mice generate all epithelial cell types within the intact follicle and hair during normal hair follicle cycling and provide potential targets for the treatment of hair loss and other disorders of skin and hair.
Journal ArticleDOI
STEM CELL NICHE: Structure and Function
Linheng Li,Ting Xie +1 more
TL;DR: A comparative summary of the differences and commonalities of different stem cell niches in Drosophila ovary/testis and Caenorhabditis elegans distal tip as well as in mammalian bone marrow, skin/hair follicle, intestine, brain, and testis is compared.
Journal ArticleDOI
p63 Is Essential for the Proliferative Potential of Stem Cells in Stratified Epithelia
TL;DR: P63, a gene whose deletion in mice results in the catastrophic loss of all stratified epithelia, is analyzed and it is demonstrated that p63 is strongly expressed in epithelial cells with high clonogenic and proliferative capacity and that stem cells lacking p63 undergo a premature proliferative rundown.
Journal ArticleDOI
Nestin expression: a property of multi-lineage progenitor cells?
Cornelia Wiese,Alexandra Rolletschek,Gabriela Kania,Przemyslaw Blyszczuk,Kirill V. Tarasov,Yelena S. Tarasova,Robert P. Wersto,Kenneth R. Boheler,Anna M. Wobus +8 more
TL;DR: It is shown that nestin is abundant in ES-derived progenitor cells that have the potential to develop into neuroectodermal, endodermal and mesodermal lineages and suggested that its presence in cells may indicate multi-potentiality and regenerative potential.
References
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Journal ArticleDOI
Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem Cell
Diane S. Krause,Neil D. Theise,Michael I. Collector,Octavian Henegariu,Sonya Hwang,Rebekah Gardner,Sara Neutzel,Saul J. Sharkis +7 more
TL;DR: It is shown that rare cells that home to bone marrow can LTR primary and secondary recipients, and this finding may contribute to clinical treatment of genetic disease or tissue repair.
Journal ArticleDOI
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
Annie Yang,Ronen Schweitzer,Deqin Sun,Mourad Kaghad,Nancy Walker,Roderick T. Bronson,Clifford J. Tabin,Arlene H. Sharpe,Daniel Caput,Christopher P. Crum,Frank McKeon +10 more
TL;DR: It is reported that mice homozygous for a disrupted p63 gene have major defects in their limb, craniofacial and epithelial development, and results indicate that p63 is critical for maintaining the progenitor-cell populations that are necessary to sustain epithelialDevelopment and morphogenesis.
Journal ArticleDOI
p63 is a p53 homologue required for limb and epidermal morphogenesis.
TL;DR: P63 is essential for several aspects of ectodermal differentiation during embryogenesis, including hair follicles, teeth and mammary glands, which are absent in p63-deficient mice.
Journal ArticleDOI
Dystrophin expression in the mdx mouse restored by stem cell transplantation
Emanuela Gussoni,Yuko Soneoka,Corinne D. Strickland,Elizabeth A. Buzney,Mohamed K. Khan,Alan F. Flint,Louis M. Kunkel,Louis M. Kunkel,Richard C. Mulligan +8 more
TL;DR: Results suggest that the transplantation of different stem cell populations, using the procedures of bone marrow transplantation, might provide an unanticipated avenue for treating muscular dystrophy as well as other diseases where the systemic delivery of therapeutic cells to sites throughout the body is critical.
Journal ArticleDOI
Out of Eden: Stem Cells and Their Niches
Fiona M. Watt,Brigid L.M. Hogan +1 more
TL;DR: Both intrinsic and extrinsic signals regulate stem cell fate and some of these signals have now been identified and can be exploited in the application of stem cells to tissue replacement therapy.
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