Stem cell therapies and benefaction of somatic cell nuclear transfer cloning in COVID-19 era.
Birbal Singh,Gorakh Mal,Vinod Verma,Ruchi Tiwari,Muhammad Imran Khan,Ranjan K. Mohapatra,Saikat Mitra,Salem A. Alyami,Talha Bin Emran,Kuldeep Dhama,Mohammad Ali Moni +10 more
Reads0
Chats0
TLDR
In this article, the authors proposed the use of mesenchymal stem cells (MSCs) to treat acute respiratory distress syndrome (ARDS) caused by SARS-CoV-2 infection.Abstract:
The global health emergency of COVID-19 has necessitated the development of multiple therapeutic modalities including vaccinations, antivirals, anti-inflammatory, and cytoimmunotherapies, etc. COVID-19 patients suffer from damage to various organs and vascular structures, so they present multiple health crises. Mesenchymal stem cells (MSCs) are of interest to treat acute respiratory distress syndrome (ARDS) caused by SARS-CoV-2 infection. Stem cell-based therapies have been verified for prospective benefits in copious preclinical and clinical studies. MSCs confer potential benefits to develop various cell types and organoids for studying virus-human interaction, drug testing, regenerative medicine, and immunomodulatory effects in COVID-19 patients. Apart from paving the ways to augment stem cell research and therapies, somatic cell nuclear transfer (SCNT) holds unique ability for a wide range of health applications such as patient-specific or isogenic cells for regenerative medicine and breeding transgenic animals for biomedical applications. Being a potent cell genome-reprogramming tool, the SCNT has increased prominence of recombinant therapeutics and cellular medicine in the current era of COVID-19. As SCNT is used to generate patient-specific stem cells, it avoids dependence on embryos to obtain stem cells. The nuclear transfer cloning, being an ideal tool to generate cloned embryos, and the embryonic stem cells will boost drug testing and cellular medicine in COVID-19.read more
Citations
More filters
Journal ArticleDOI
Stem Cell Transplantation Therapy and Neurological Disorders: Current Status and Future Perspectives
Mohammad Mominur Rahman,Mohammad Rezaul Islam,Mohammad Touhidul Islam,M. Harun-or-Rashid,Mahfuzul Islam,Sabirin Abdullah,Mohammad Borhan Uddin,Sumit Das,Mohammad Saidur Rahaman,Muniruddin Ahmed,Fahad A. Alhumaydhi,Talha Bin Emran,Amany Abdel-Rahman Mohamed,Mohammad Rashed Iqbal Faruque,Mayeen Uddin Khandaker,Gomaa Mostafa-Hedeab +15 more
TL;DR: The stem cell-based therapies that have been explored for various neurological disorders are summarized, the potential advantages and drawbacks of these therapies are discussed, and future directions for this field are examined.
Journal ArticleDOI
Current insights and molecular docking studies of the drugs under clinical trial as rdrp inhibitors in COVID-19 treatment.
Irine Pauly,Ankit Kumar Singh,Adarsh Raj Dr.K.N.Chandan Kumar,Yogesh Kumar Harvijay Singh,Suresh Thareja,Mohammad Amjad Kamal,Amita Verma,Pradeep Kumar +7 more
TL;DR: In this paper , the authors used the Maestro 12.9 module of Schrodinger software over 70 molecules with rdrp as the target and remdesivir as the standard drug and further confirmed by simulation studies.
Journal ArticleDOI
Stem Cells as a Model of Study of SARS-CoV-2 and COVID-19: A Systematic Review of the Literature.
María Verónica Cuevas-González,Álvaro García-Pérez,Álvaro Edgar González-Aragón Pineda,León Francisco Espinosa-Cristóbal,Alejandro Donohue-Cornejo,Karla Lizette Tovar-Carrillo,Rosa Alicia Saucedo-Acuña,Juan Carlos Cuevas-González +7 more
TL;DR: In this paper, the role of stem cells in the study of SARS-CoV-2 and the treatment of COVID-19 has been evaluated, and the authors evaluated the potential of using stem cells as a study model and as a possible therapeutic source against tissue damage caused by this virus.
Book ChapterDOI
Somatic cell nuclear transfer in cellular medicine and biopharming
TL;DR: The somatic cell nuclear transfer (SCNT) has pioneered a new era in cellular medicine and biopharming as discussed by the authors , which is used to generate patient-specific stem cells, thus it avoids dependence on embryos to produce embryonic stem cells (ESCs) which has stern ethical concerns in humans.
References
More filters
Journal ArticleDOI
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
TL;DR: Induction of pluripotent stem cells from mouse embryonic or adult fibroblasts by introducing four factors, Oct3/4, Sox2, c-Myc, and Klf4, under ES cell culture conditions is demonstrated and iPS cells, designated iPS, exhibit the morphology and growth properties of ES cells and express ES cell marker genes.
Journal ArticleDOI
COVID-19: consider cytokine storm syndromes and immunosuppression
Puja Mehta,Daniel F. McAuley,Michael Brown,Emilie Sanchez,Rachel Tattersall,Rachel Tattersall,Jessica J Manson +6 more
TL;DR: Re-analysis of data from a phase 3 randomised controlled trial of IL-1 blockade (anakinra) in sepsis, showed significant survival benefit in patients with hyperinflammation, without increased adverse events.
Journal ArticleDOI
Endothelial cell infection and endotheliitis in COVID-19.
Zsuzsanna Varga,Andreas J. Flammer,Peter Steiger,Martina Haberecker,Rea Andermatt,Annelies S. Zinkernagel,Mandeep R. Mehra,Reto A. Schuepbach,Frank Ruschitzka,Holger Moch +9 more
TL;DR: The vascular endothelium is an active paracrine, endocrine, and Endothelial cell infection and endotheliitis in COVID-19 and recruitment of immune cells can result in widespread endothelial dysfunction associated with apoptosis.
Journal ArticleDOI
Intravenous hMSCs Improve Myocardial Infarction in Mice because Cells Embolized in Lung Are Activated to Secrete the Anti-inflammatory Protein TSG-6
Ryang Hwa Lee,Andrey A. Pulin,Min Jeong Seo,Daniel J. Kota,Daniel J. Kota,Joni Ylostalo,Joni Ylostalo,Benjamin L. Larson,Benjamin L. Larson,Laura Semprun-Prieto,Patrice Delafontaine,Darwin J. Prockop,Darwin J. Prockop +12 more
TL;DR: Quantitative assays for human DNA and mRNA were used to examine the paradox that intravenously infused human multipotent stromal cells (hMSCs) can enhance tissue repair without significant engraftment and suggest that improvements in animal models and patients after i.v. infusions of MSCs are at least in part explained by activation of M SCs to secrete TSG-6.