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Journal ArticleDOI

Stereochemical activity of lone pairs of electrons and supramolecular aggregation patterns based on secondary interactions involving tellurium in its 1,1-dithiolate structures

TL;DR: In this article, a survey of the literature of tellurium(II)/(IV) 1,1-dithiolates (dithiocarbamate, xanthate, dithiophosphate, or dithIophosphinate) is presented.
About: This article is published in Coordination Chemistry Reviews.The article was published on 2010-01-01. It has received 44 citations till now. The article focuses on the topics: Lone pair & Ligand.
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TL;DR: In this paper, a review describes how non-covalent interactions, such as hydrogen (inter-and intramolecular, resonance-and charge-assisted hydrogen bonding), halogen, chalcogen and pnicogen bonds, π-interactions, as well as other types of weak forces can influence and control the reactions in the synthesis, providing a class of highly directional stabilizing contacts that can be exploited in the design of coordination compounds.

231 citations

Journal ArticleDOI
TL;DR: An overview of supramolecular assembly sustained by intermolecular contacts pertinent to the coordination chemistry community is presented in this paper, with comments on the nature of these interactions and information on the energy of stabilisation they impart.

163 citations

Journal ArticleDOI
TL;DR: Oligomeric aggregates of heterocycles that are linked by chalcogen-centered interactions and behave as genuine macrocyclic species are presented.
Abstract: Organic molecules with heavy main-group elements frequently form supramolecular links to electron-rich centres. One particular case of such interactions is halogen bonding. Most studies of this phenomenon have been concerned with either dimers or infinitely extended structures (polymers and lattices) but well-defined cyclic structures remain elusive. Here we present oligomeric aggregates of heterocycles that are linked by chalcogen-centered interactions and behave as genuine macrocyclic species. The molecules of 3-methyl-5-phenyl-1,2-tellurazole 2-oxide assemble a variety of supramolecular aggregates that includes cyclic tetramers and hexamers, as well as a helical polymer. In all these aggregates, the building blocks are connected by Te(…)O-N bridges. Nuclear magnetic resonance spectroscopic experiments demonstrate that the two types of annular aggregates are persistent in solution. These self-assembled structures form coordination complexes with transition-metal ions, act as fullerene receptors and host small molecules in a crystal.

151 citations

Journal ArticleDOI
TL;DR: The overview presented here has the goal of examining whether carbon disulfide (CS2) may play a role as an endogenously generated bioregulator and/or has therapeutic value and suggests that the very nature of CS2 poisoning may be related to interrupting or overwhelming relevant regulatory or signaling process(es), much like other SMBs.
Abstract: The overview presented here has the goal of examining whether carbon disulfide (CS2) may play a role as an endogenously generated bioregulator and/or has therapeutic value. The neuro- and reproductive system toxicity of CS2 has been documented from its long-term use in the viscose rayon industry. CS2 is also used in the production of dithiocarbamates (DTCs), which are potent fungicides and pesticides, thus raising concern that CS2 may be an environmental toxin. However, DTCs also have recognized medicinal use in the treatment of heavy metal poisonings as well as having potency for reducing inflammation. Three known small molecule bioregulators (SMBs) nitric oxide, carbon monoxide, and hydrogen sulfide were initially viewed as environmental toxins. Yet each is now recognized as having intricate, though not fully elucidated, biological functions at concentration regimes far lower than the toxic doses. The literature also implies that the mammalian chemical biology of CS2 has broader implications from inflammatory states to the gut microbiome. On these bases, we suggest that the very nature of CS2 poisoning may be related to interrupting or overwhelming relevant regulatory or signaling process(es), much like other SMBs.

58 citations

Journal ArticleDOI
TL;DR: In this article, the synthesis, characterization and antifungal activity of the complexes were described, and the results were compared with those of nystatin and miconazole nitrate, used as control drugs.

47 citations

References
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16,894 citations

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TL;DR: The Cambridge Structural Database now contains data for more than a quarter of a million small-molecule crystal structures, and projections concerning future accession rates indicate that the CSD will contain at least 500,000 crystal structures by the year 2010.
Abstract: The Cambridge Structural Database (CSD) now contains data for more than a quarter of a million small-molecule crystal structures. The information content of the CSD, together with methods for data acquisition, processing and validation, are summarized, with particular emphasis on the chemical information added by CSD editors. Nearly 80% of new structural data arrives electronically, mostly in CIF format, and the CCDC acts as the official crystal structure data depository for 51 major journals. The CCDC now maintains both a CIF archive (more than 73000 CIFs dating from 1996), as well as the distributed binary CSD archive; the availability of data in both archives is discussed. A statistical survey of the CSD is also presented and projections concerning future accession rates indicate that the CSD will contain at least 500000 crystal structures by the year 2010.

9,865 citations