Stereotactic body radiation therapy for early-stage non-small cell lung cancer: Executive Summary of an ASTRO Evidence-Based Guideline
Citations
288 citations
Cites background or result from "Stereotactic body radiation therapy..."
...INTRODUCTION Stereotactic body radiotherapy (SBRT), that is, a few, high-dose, very conformal, precisely delivered radiation treatments, has become the standard of care for medically inoperable patients with node-negative non–small-cell lung cancer (NSCLC).(1,2) It is well tolerated and provides high rates of local control,(3) and its introduction has been associated with improved survival at a population level....
[...]
...A 2-year OS of 70% in this medically inoperable group of mostly elderly patients with comorbidities compares favorably with an SBRT series for peripheral tumors.(2,5) Several groups have reported on outcomes of SBRT for centrally located lung cancers....
[...]
113 citations
Cites background from "Stereotactic body radiation therapy..."
...5%.(71) Patients deemed at excessive risk for complications...
[...]
...The results of the combined analysis of the STARS and ROSEL trials, which showed improved overall survival and decreased toxicity with SBRT, provide justification for ongoing randomized trials comparing surgery and SBRT....
[...]
...Overall health-related quality of life does not appear to be significantly affected by SBRT.43 Grade 5 toxicity, or toxicity resulting in death, is uncommon after SBRT....
[...]
...RTOG 0236 demonstrated that progression elsewhere within the index lobe is a concern after SBRT....
[...]
...Not all patients in published SBRT series or in routine clinical practice have pathologic confirmation of NSCLC before they undergo SBRT....
[...]
112 citations
105 citations
104 citations
Cites methods from "Stereotactic body radiation therapy..."
...Histologic confirmation was not mandatory, but if a biopsy could not be performed because of a contraindication, progression according to RECIST on at least 2 serial CT imaging studies or an increased 18F-FDG uptake on PET/CT were necessary, according to recommendations (9)....
[...]
References
7,710 citations
5,228 citations
2,202 citations
1,340 citations
1,009 citations