Sterol Regulatory Element-binding Protein-1 as a Key Transcription Factor for Nutritional Induction of Lipogenic Enzyme Genes
Hitoshi Shimano,Naoya Yahagi,Michiyo Amemiya-Kudo,Alyssa H. Hasty,Jun-ichi Osuga,Yoshiaki Tamura,Futoshi Shionoiri,Yoko Iizuka,Ken Ohashi,Kenji Harada,Takanari Gotoda,Shun Ishibashi,Nobuhiro Yamada +12 more
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TLDR
It is demonstrated that SREBP-1 plays a crucial role in the induction of lipogenesis but not cholesterol biosynthesis in liver when excess energy by carbohydrates is consumed.About:
This article is published in Journal of Biological Chemistry.The article was published on 1999-12-10 and is currently open access. It has received 668 citations till now. The article focuses on the topics: Sterol regulatory element-binding protein 2 & Fatty acid synthase.read more
Citations
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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
TL;DR: The complex, interdigitated roles of these three SREBPs have been dissected through the study of ten different lines of gene-manipulated mice and form the subject of this review.
Journal ArticleDOI
Cardiorespiratory Fitness as a Quantitative Predictor of All-Cause Mortality and Cardiovascular Events in Healthy Men and Women: A Meta-analysis
Satoru Kodama,Kazumi Saito,Shiro Tanaka,Miho Maki,Yoko Yachi,Mihoko Asumi,Ayumi Sugawara,Kumiko Totsuka,Hitoshi Shimano,Yasuo Ohashi,Nobuhiro Yamada,Hirohito Sone +11 more
TL;DR: In this article, a systematic literature search was conducted for observational cohort studies using MEDLINE (1966 to December 31, 2008) and EMBASE (1980 to December 30, 2008), which reported associations of baseline cardiorespiratory fitness with CHD events, CVD events, or all-cause mortality in healthy participants.
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Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Javier A. Menendez,Ruth Lupu +1 more
TL;DR: FASN, a nearly-universal druggable target in many human carcinomas and their precursor lesions, offers new therapeutic opportunities for metabolically treating and preventing cancer.
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Transcriptional regulation of adipogenesis
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Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ
Joyce J. Repa,Guosheng Liang,Jiafu Ou,Yuriy Bashmakov,Jean-Marc A. Lobaccaro,Iichiro Shimomura,Bei Shan,Michael S. Brown,Joseph L. Goldstein,David J. Mangelsdorf +9 more
TL;DR: A novel LXR target is described, the sterol regulatory element-binding protein-1c gene (SREBP-1C), which encodes a membrane-bound transcription factor of the basic helix-loop-helix-leucine zipper family and reveals a unique regulatory interplay between cholesterol and fatty acid metabolism.
References
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Journal ArticleDOI
The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor
TL;DR: This research was supported by grants from the National Institutes of Health (HL20948) and the Perot Family Foundation.
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ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism.
Jae Bum Kim,Bruce M. Spiegelman +1 more
TL;DR: Data indicate that ADD1 plays an important role in fat cell gene expression and differentiation, and suggest that it may function by augmenting a step in PPARgamma-mediated transcription.
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SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene
Chieko Yokoyama,Xiaodong Wang,Michael R. Briggs,Arie Admon,Jian Wu,Xianxin Hua,Joseph L. Goldstein,Michael S. Brown +7 more
TL;DR: The cDNA cloning of human SREBP-1 is reported, a protein that binds SRE-1, activates transcription, and thereby mediates the final regulatory step in LDL metabolism, abolishing sterol regulation.
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Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.
Hitoshi Shimano,Jay D. Horton,Robert E. Hammer,Iichiro Shimomura,Michael S. Brown,Joseph L. Goldstein +5 more
TL;DR: It is indicated that the NH2-terminal domain of SREBP-1a can produce major effects on lipid synthesis and storage in the liver, owing to the engorgement of hepatocytes with cholesterol and triglycerides.
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Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.
Hitoshi Shimano,Jay D. Horton,Iichiro Shimomura,Robert E. Hammer,Michael S. Brown,Joseph L. Goldstein +5 more
TL;DR: SRE BP-1a is the most active form of SREBP-1 and that SREbp-1c may be produced when cells require a lower rate of transcription of genes regulating cholesterol and fatty acid metabolism.