Journal ArticleDOI
Stimuli-responsive polymers: Biomedical applications and challenges for clinical translation ☆
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TLDR
This article briefly overviews the field of stimuli-responsive polymers and describes some of the most successful biomedical applications to date of such "smart" polymers.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2013-01-01. It has received 615 citations till now.read more
Citations
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Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles
TL;DR: This review provides a comprehensive summary of how nanoparticle and biological factors impact nanoparticle delivery to tumors, with discussion on how the tumor microenvironment can be adjusted and how patients can be stratified by imaging methods to receive the maximal benefit of nanomedicine.
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Self-healing gels based on constitutional dynamic chemistry and their potential applications
Zhao Wei,Jianhai Yang,Jinxiong Zhou,Feng Xu,Miklós Zrínyi,Patrick H. Dussault,Yoshihito Osada,Yong Mei Chen +7 more
TL;DR: An overview of the current strategies for synthesizing self-healing gels based on the concept of constitutional dynamic chemistry, which involves molecular structures capable of establishing dynamic networks based upon physical interactions or chemical reactions is presented.
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Nanocomposite Hydrogels: 3D Polymer–Nanoparticle Synergies for On-Demand Drug Delivery
TL;DR: This review highlights the latest advances in nanocomposite hydrogels as drug delivery vehicles and the inclusion/incorporation of nanoparticles in three-dimensional polymeric structures is an innovative means for obtaining multicomponent systems with diverse functionality within a hybrid hydrogel network.
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Redox-responsive polymers for drug delivery: from molecular design to applications
TL;DR: This review discusses the reduction- and oxidation-responsive polymeric drug carriers from the view of functional groups, as well as their applications in controlled release.
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MOF-Polymer Hybrid Materials: From Simple Composites to Tailored Architectures.
Mark Kalaj,Kyle C. Bentz,Sergio Ayala,Joseph M. Palomba,Kyle S Barcus,Yuji Katayama,Yuji Katayama,Seth M. Cohen +7 more
TL;DR: This Review highlights the development and recent advances in the synthesis of MOF-polymer mixed-matrix membranes (MMMs) and applications of these MMMs in gas and liquid separations and purifications, including aqueous applications such as dye removal, toxic heavy metal sequestration, and desalination.
References
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Journal ArticleDOI
Solution Properties of Poly(N-isopropylacrylamide)
M. Heskins,J. E. Guillet +1 more
TL;DR: In this paper, a lower critical solution temperature of poly(N-isopropyl acrylamide was found to be due to an entropy effect, which was attributed to the formation of nonpolar and intermolecular hydrogen bonds.
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Thermosensitive sol-gel reversible hydrogels.
TL;DR: It is timely to summarize the polymeric systems that undergo sol-gel transitions, particularly due to temperature, with emphasis on the underlying transition mechanisms and potential delivery aspects.
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Future perspectives and recent advances in stimuli-responsive materials
TL;DR: It is the goal to emphasize underutilized adaptive behaviors of stimuli-responsive polymers so that novel applications and new generations of smart materials can be realized.
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Comb-type grafted hydrogels with rapid deswelling response to temperature changes
Ryo Yoshida,Katsumi Uchida,Yuzo Kaneko,Kiyotaka Sakai,Akihiko Kikuchi,Yasuhisa Sakurai,Teruo Okano +6 more
TL;DR: In this paper, a crosslinked polymeric hydrogel with grafted side chains was used to induce rapid de-swelling by tailoring the polymeric gel architecture at the molecular level.