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Journal ArticleDOI

Stoffwechselprodukte von Actinomyceten. 3. Mitteilung. Nonactin

01 Jan 1955-Helvetica Chimica Acta (WILEY‐VCH Verlag GmbH)-Vol. 38, Iss: 6, pp 1445-1448
TL;DR: Aus Kulturfiltrat und Mycel eines Streptomyces viridochromogenes oder Strobelsomycetes nahestehenden strobelsyceten wurde neben Actidion eine neutrale, farblose, kristalline Verbindung C30H48O9, das Nonactin, isoliert, die chemisch wenig reaktiv ist und gegenuber den untersuchten Mikroorganismen unwir
Abstract: Aus Kulturfiltrat und Mycel eines Streptomyces viridochromogenes oder Streptomyces olivochromogenes nahestehenden Streptomyceten wurde neben Actidion eine neutrale, farblose, kristalline Verbindung C30H48O9, das Nonactin, isoliert, die chemisch wenig reaktiv ist und gegenuber den untersuchten Mikroorganismen unwirksam oder nur schwach wirksam war.
Citations
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Journal ArticleDOI
TL;DR: Candida lipolytica synthetisiert das Antibioticum Tryptanthrin aus 1 Mol Tryptophan and 1 Mol Anthranilsaure as mentioned in this paper.
Abstract: Candida lipolytica synthetisiert das Antibioticum Tryptanthrin aus 1 Mol Tryptophan und 1 Mol Anthranilsaure. Bei Verfutterung von Tryptophan und substituierter Anthranilsaure, bzw. substituiertem Tryptophan und Anthranilsaure, konnten die zu erwartenden Tryptanthrinderivate isoliert und identifiziert werden. Die Enzyme der Tryptanthrinbiosynthese wiesen in bezug auf diese Substrate, mit Ausnahme von Bromtryptophan, keine Spezifitat auf. Parallel zu diesen Versuchen wurden durch chemische Synthese substituierte Tryptanthrine hergestellt. Die Dierivate wurden auf ihre antibiotische Wirksamkeit gepruft; als besonders wirksam erwiesen sich die halogenierten Verbindungen.

328 citations

Journal ArticleDOI
TL;DR: In nature, chiral natural products are usually produced in optically pure form-however, occasionally both enantiomers are formed; these enantiomeric natural products can arise from a single species or from different genera and/or species.
Abstract: In nature, chiral natural products are usually produced in optically pure form-however, occasionally both enantiomers are formed. These enantiomeric natural products can arise from a single species or from different genera and/or species. Extensive research has been carried out over the years in an attempt to understand the biogenesis of naturally occurring enantiomers; however, many fascinating puzzles and stereochemical anomalies still remain.

226 citations

Journal ArticleDOI
TL;DR: This Review assembles a collection of classic and current cases that illustrate and underscore the scientific possibilities for practitioners of chemical synthesis.
Abstract: The systematic modification of natural products through diverted total synthesis is a powerful concept for the systematic modification of natural products with the aim of studying mechanistic aspects of their biological activity. This concept offers far-reaching opportunities for discovery at the interface of biology and chemistry. It is underpinned by the power of chemical synthesis, which manifests itself in the ability to modify structure at will. Its implementation, when combined with innovative design, enables the preparation of unique mechanistic probes that can be decisive in differentiating and validating biological hypotheses at the molecular level. This Review assembles a collection of classic and current cases that illustrate and underscore the scientific possibilities for practitioners of chemical synthesis.

147 citations

Journal ArticleDOI
TL;DR: An investigation and classification of the streptomycetes producing macrolides, is added; the single species are critically revised.
Abstract: The macrolide-antibiotics are discussed in respect to their chemistry and biology. The single substances are listed. An investigation and classification of the streptomycetes producing macrolides, is added; the single species are critically revised. Relations are established between the producers and their products.

78 citations


Cites background from "Stoffwechselprodukte von Actinomyce..."

  • ...Stres eurythermus Stature ETH 6677, Lectotypus yon Streptomyces eurythermus Corbaz et al. 1955, Stature ]~TH 6905 und Stature ETI-[ 7489, Produzenten yon Angolamyein....

    [...]

References
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Journal ArticleDOI
TL;DR: Taylor and Decker (1947) showed that various plant pathogenic actinomycetes could be separated from nonpathogenic isolates on the basis of their reactions on carbon compounds, as well as other criteria.
Abstract: Attention has recently been focused on the identification of the actinomycetes because of the ability of some members of this group to produce antibiotics. The determinative procedures now in use are based primarily on morphology, pigmentation, and growth characteristics on media composed of complex natural substrates. With such media one can often observe a variety of pigments and colony types produced by the same organism. In inexperienced hands, this leads to difficulties in interpretation of results, and one is often forced to designate a particular isolate as one of several species rather than one distinct species. To aid in the identification of a group of antibiotic-producing actinomycetes under study, an intensive investigation of their utilization of carbon compounds in chemically defined media was undertaken. Prior to the current investigations a number of workers had studied the utilization of carbon compounds by some species in this group. Beijerinck (1900), Sames (1900), Caminiti (1913), Fousek (cited by Waksman, 1919), Krainsky (1914), and Gray and Thornton (1928) each tested a few materials and found that various members of this group could grow on media containing different carbon sources. More extensive tests on carbon compounds were made by Salzmann (1907), Munter (1913), and Waksman (1919). Recently Taylor and Decker (1947) showed that various plant pathogenic actinomycetes could be separated from nonpathogenic isolates on the basis of their reactions on carbon compounds, as well as other criteria. The studies of Cochrane (1947) also indicated that different species in the genus Actinomyces might be separated on the basis of acid production.

773 citations

Journal ArticleDOI
TL;DR: Aus dem Kulturfiltrat von Streptomyces eurythermus n. sp. konnte ein neues lipophiles kristallines basisches Antibioticum C50±1H89±2O18N, das Angolamycin, isoliert werden.
Abstract: Aus dem Kulturfiltrat von Streptomyces eurythermus n. sp. konnte ein neues lipophiles kristallines basisches Antibioticum C50±1H89±2O18N, das Angolamycin, isoliert werden.

20 citations