Storage and Flow of Solids
01 Jan 1964-
About: The article was published on 1964-01-01 and is currently open access. It has received 585 citations till now. The article focuses on the topics: Flow (mathematics).
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TL;DR: In this article, the authors used atomic force microscopy (AFM) to measure and identify the nature of the forces acting between single pharmaceutical powder particles, namely a crystalline and a semi-crystalline form of lactose.
11 citations
TL;DR: In this article, a simple method for evaluating particulate solids flow properties based on a solid extrusion procedure is assessed, and the effects of the main geometrical parameters of the tester and of the testing operating condition are investigated.
Abstract: The increasing interest in combustion of solid recovered fuels (SRF), whose physical properties may significantly differ from those of conventional solid fuels, draws attention to the handling of these materials. In this article a simple method for evaluating particulate solids flow properties based on a solid extrusion procedure is assessed. The effects of the main geometrical parameters of the tester and of the testing operating condition are investigated. Results are critically discussed by comparing them with the flow properties evaluated in a Schulze ring shear tester.
10 citations
TL;DR: In this paper, the roll compaction process of dusty caustic magnesia carried out by using vinasses and molasses from the sugar beet industry as organic binders was investigated.
10 citations
TL;DR: This study investigated how formulations could be simplified to use a small number of excipients for a number of different API’s in which long term stability is not required, and developed a miniature platform for on-demand manufacturing of direct compressible tablets.
Abstract: Oral direct compressible tablets are the most frequently used drug products. Manufacturing of tablets requires design and development of formulations, which need a number of excipients. The choice of excipients depends on the concentration, manufacturability, stability, and bioavailability of the active pharmaceutical ingredients (APIs). At MIT, we developed a miniature platform for on-demand manufacturing of direct compressible tablets. This study investigated how formulations could be simplified to use a small number of excipients for a number of different API’s in which long term stability is not required. Direct compressible tablets of five pharmaceutical drugs, Diazepam, Diphenhydramine HCl, Doxycycline Monohydrate, Ibuprofen, and Ciprofloxacin HCl, with different drug loadings, were made using direct compression in an automated small scale system.. The critical quality attributes (CQA) of the tablets were assessed for the quality standards set by the United States Pharmacopeia (USP). This miniature system can manufacture tablets - on-demand from crystalline API using the minimum number of excipients required for drug product performance. All drug tablets met USP quality standards after manufacturing and after 2 weeks of accelerated stability test, except for slightly lower drug release for Ibuprofen. On-demand tablets manufacturing where there is no need for long term stability using a flexible, miniature, automated (integrated) system will simplify pharmaceutical formulation design compared to traditional formulations. This advancement will offer substantial economic benefits by decreasing product time-to-market and enhancing quality.
10 citations
TL;DR: FEM may be the best option for producing desired sized dry coated fine excipients, having desirable bulk density, FFC, and tensile strength that could facilitate high-speed direct compression tableting.
10 citations