Journal ArticleDOI
Strategies for active tumor targeting-an update
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TLDR
In this paper, the authors present an outline of the current significant targets for active tumor drug delivery systems and provide insight into the direction of active tumor-targeting strategies, including angiogenesis mediated targeting, receptor-mediated targeting and peptide targeting.About:
This article is published in European Journal of Pharmacology.The article was published on 2021-09-20. It has received 14 citations till now. The article focuses on the topics: Medicine & Tumor microenvironment.read more
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Enzyme-Responsive Hydrogels as Potential Drug Delivery Systems—State of Knowledge and Future Prospects
TL;DR: The state-of-the art in ERHs designed for controlled drug delivery systems (DDSs) were reviewed and differentERHs were further characterized focusing mainly on glucose oxidase-, β-galactosidase- and metalloproteinases-based catalyzed reactions.
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Sustained Drug Release from Smart Nanoparticles in Cancer Therapy: A Comprehensive Review
TL;DR: In this review, the state-of-the-art of smart sustained release nanoparticles is discussed, focusing on the design strategies and performances of polymeric nanotechnologies.
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A perspective review on impact and molecular mechanism of environmental carcinogens on human health.
TL;DR: In this paper, a review aims to discuss different types of environmental carcinogens and their respective mechanisms responsible for inducing cancer in humans, including genetic and epigenetic mechanisms of carcinogenesis of a wide range of carcinogens.
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Biocompatible Iron Oxide Nanoparticles for Targeted Cancer Gene Therapy: A Review
TL;DR: The latest progress in targeting cancer gene therapy is introduced, and the unique properties of IONPs contributing to the efficient delivery of therapeutic genes are summarized with detailed examples.
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Red-Absorbing Ru(II) Polypyridyl Complexes with Biotin Targeting Spontaneously Assemble into Nanoparticles in Biological Media.
TL;DR: Four new ruthenium(II) polypyridyl complexes synthesized to study the effect of poly(ethylene glycol) and/or biotin conjugation on their physical and biological properties self-assembled into nanoparticles upon dilution in biological media and are a promising backbone for the development of new lysosome-targeted photosensitizers for photodynamic therapy.
References
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Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal Article
A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
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Myeloid-derived suppressor cells as regulators of the immune system.
TL;DR: The origin, mechanisms of expansion and suppressive functions of MDSCs, as well as the potential to target these cells for therapeutic benefit are discussed.
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Tumorigenesis and the angiogenic switch
TL;DR: A more detailed understanding of the complex parameters that govern the interactions between the tumour and vascular compartments will help to improve anti-angiogenic strategies — not only for cancer treatment, but also for preventing recurrence.
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The biology and function of fibroblasts in cancer
TL;DR: Cancer-associated fibroblasts (CAFs) become synthetic machines that produce many different tumour components and have a role in creating extracellular matrix structure and metabolic and immune reprogramming of the tumour microenvironment with an impact on adaptive resistance to chemotherapy.