Journal ArticleDOI
Strategies to Improve Cancer Photothermal Therapy Mediated by Nanomaterials.
Duarte de Melo-Diogo,Cleide Pais-Silva,Diana Rodrigues Dias,André F. Moreira,Ilídio J. Correia +4 more
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TLDR
This progress report summarizes the different strategies that have been applied so far for increasing the efficacy of the photothermal therapeutic effect mediated by nanomaterials, namely those that improve the accumulation of nanommaterials in tumors (e.g. by changing the corona composition or through the functionalization with targeting ligands), and the development of new strategies or the optimization and combination of the existing ones.Abstract:
The deployment of hyperthermia-based treatments for cancer therapy has captured the attention of different researchers worldwide. In particular, the application of light-responsive nanomaterials to mediate hyperthermia has revealed promising results in several pre-clinical assays. Unlike conventional therapies, these nanostructures can display a preferential tumor accumulation and thus mediate, upon irradiation with near-infrared light, a selective hyperthermic effect with temporal resolution. Different types of nanomaterials such as those based on gold, carbon, copper, molybdenum, tungsten, iron, palladium and conjugated polymers have been used for this photothermal modality. This progress report summarizes the different strategies that have been applied so far for increasing the efficacy of the photothermal therapeutic effect mediated by nanomaterials, namely those that improve the accumulation of nanomaterials in tumors (e.g. by changing the corona composition or through the functionalization with targeting ligands), increase nanomaterials' intrinsic capacity to generate photoinduced heat (e.g. by synthesizing new nanomaterials or assembling nanostructures) or by optimizing the parameters related to the laser light used in the irradiation process (e.g. by modulating the radiation wavelength). Overall, the development of new strategies or the optimization and combination of the existing ones will surely give a major contribution for the application of nanomaterials in cancer PTT.read more
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Engineering Macrophages for Cancer Immunotherapy and Drug Delivery.
TL;DR: There is still significant room for development in macrophage‐mediated immune modulation and macrophages‐mediated drug delivery, which will further enhance current tumor therapies against various malignant solid tumors, including drug‐resistant tumors and metastatic tumors.
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Recent advances in nanomaterials for enhanced photothermal therapy of tumors.
TL;DR: This review highlights recent advances in nanomaterials that focus on overcoming the above obstacles and thus enhancing the therapeutic outcome of PTT, and classification of PTAs with improved photothermal performance and modification strategies for efficient PTT are summarized.
Journal ArticleDOI
Supramolecular Photothermal Nanomaterials as an Emerging Paradigm toward Precision Cancer Therapy
TL;DR: This review considers organic supramolecular photothermal materials assembled at the nanoscale via various molecular self-assembly strategies and associated with the organization of multiple noncovalent interactions, including polymer and protein fabrication, small molecule self‐assembly, and the construction of donor–acceptor binary systems.
Journal ArticleDOI
Overview of the application of inorganic nanomaterials in cancer photothermal therapy
Natanael Fernandes,Carolina F. Rodrigues,André F. Moreira,Ilídio J. Correia,Ilídio J. Correia +4 more
TL;DR: The most common inorganic nanomaterials, such as gold, carbon-based materials, tungsten, copper, molybdenum, and iron oxide, which have been explored for mediating a tumor-localized photothermal effect, are summarized.
Journal ArticleDOI
Progress in Applications of Prussian Blue Nanoparticles in Biomedicine.
Zhiguo Qin,Yan Li,Ning Gu +2 more
TL;DR: A better understanding is provided and key consideration for rational design of this increasingly important new paradigm of PBNPs as theranostic agents is provided.
References
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Principles of nanoparticle design for overcoming biological barriers to drug delivery
TL;DR: By successively addressing each of the biological barriers that a particle encounters upon intravenous administration, innovative design features can be rationally incorporated that will create a new generation of nanotherapeutics, realizing a paradigmatic shift in nanoparticle-based drug delivery.
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Renal clearance of quantum dots.
Hak Soo Choi,Wenhao Liu,Preeti Misra,Eiichi Tanaka,John P. Zimmer,Binil Itty Ipe,Moungi G. Bawendi,John V. Frangioni,John V. Frangioni +8 more
TL;DR: This study has precisely defined the requirements for renal filtration and urinary excretion of inorganic, metal-containing nanoparticles and provides a foundation for the design and development of biologically targeted nanoparticles for biomedical applications.
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Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives
TL;DR: PEG is the most used polymer and also the gold standard for stealth polymers in the emerging field of polymer-based drug delivery and alternative polymers will be evaluated.
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Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment
Susan K. Hobbs,Wayne L. Monsky,Fan Yuan,W. G. Roberts,Linda G. Griffith,Vladimir P. Torchilin,Rakesh K. Jain +6 more
TL;DR: Delivery may be less efficient in cranial tumors than in subcutaneous tumors, delivery may be reduced during tumor regression induced by hormonal ablation, and permeability to a molecule is independent of pore cutoff size as long as the diameter of the molecule is much less than the pore diameter.