Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease
James Kinchen,Hannah Chen,Kaushal Parikh,Agne Antanaviciute,Marta Jagielowicz,David Fawkner-Corbett,Neil Ashley,Laura Cubitt,Esther Mellado-Gomez,Moustafa Attar,Eshita Sharma,Quin F. Wills,Rory Bowden,Felix Richter,David Ahern,Kamal D. Puri,Jill Henault,Francois Gervais,Hashem Koohy,Alison Simmons +19 more
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TLDR
This work defines how the colonic mesenchyme remodels to fuel inflammation and barrier dysfunction in IBD.About:
This article is published in Cell.The article was published on 2018-10-04 and is currently open access. It has received 380 citations till now. The article focuses on the topics: Mesenchyme & Population.read more
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Fibrosis: from mechanisms to medicines
TL;DR: The transformative experimental strategies that are being leveraged to dissect the key cellular and molecular mechanisms that regulate fibrosis, and the translational approaches that are enabling the emergence of precision medicine-based therapies for patients with fibrosis are discussed.
Journal ArticleDOI
Colonic epithelial cell diversity in health and inflammatory bowel disease
Kaushal Parikh,Kaushal Parikh,Agne Antanaviciute,Agne Antanaviciute,David Fawkner-Corbett,David Fawkner-Corbett,David Fawkner-Corbett,Marta Jagielowicz,Marta Jagielowicz,Anna Aulicino,Anna Aulicino,Christoffer Lagerholm,Simon J. Davis,James Kinchen,James Kinchen,Hannah H. Chen,Hannah H. Chen,Nasullah Khalid Alham,Neil Ashley,Errin Johnson,Philip Hublitz,Leyuan Bao,Leyuan Bao,Joanna Lukomska,Joanna Lukomska,Rajinder Singh Andev,Rajinder Singh Andev,Elisabet Björklund,Elisabet Björklund,Benedikt M. Kessler,Roman Fischer,Robert D. Goldin,Hashem Koohy,Alison Simmons,Alison Simmons +34 more
TL;DR: Profiling of single epithelial cells in healthy and inflamed colons identifies specialized cellular subpopulations, including a type of goblet cell that secretes the antibacterial protein WFDC2, which preserves the integrity of the epithelial barrier layer.
Journal ArticleDOI
Diversity and Biology of Cancer-Associated Fibroblasts.
Giulia Biffi,David A. Tuveson +1 more
TL;DR: The body of work on CAFs is summarized, with a particular focus on the most recent discoveries about fibroblast heterogeneity, plasticity and functions, and the commonalities of fibroblasts present across different cancer types, and in normal and inflammatory states are highlighted.
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Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease.
TL;DR: The progression of IBD from the perspective of remodeling of cytokine networks is discussed, placing well-established and under-studied cytokine modules in the context of cellular interactions, their dynamic regulation in late stages of disease and their current and potential use in the clinic.
Journal ArticleDOI
Pathway paradigms revealed from the genetics of inflammatory bowel disease.
TL;DR: IBD is described as a model disease in the context of leveraging human genetics to dissect interactions in cellular and molecular pathways that regulate homeostasis of the mucosal immune system and future prospects for disease-subtype classification and therapeutic intervention are discussed.
References
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