Journal ArticleDOI
Structural vaccinology approach to investigate the virulent and secretory proteins of Bacillus anthracis for devising anthrax next-generation vaccine
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Abstract Communicated by Ramaswamy H. Sarma is a post-graduate student of electrical engineering at the University of California, Berkeley and a member of the faculty at the California Institute of Technology, Berkeley.Abstract:
Abstract Communicated by Ramaswamy H. Sarmaread more
Citations
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Immunoinformatic design of an epitope-based immunogen candidate against Bacillus anthracis
TL;DR: The engineered recombinant protein can be efficaciously considered as a candidate immunogen and proper and stable binding affinity is revealed between epitopic protein and receptors.
Journal ArticleDOI
Designing multi-epitope subunit vaccine for ocular trachoma infection using Chlamydia trachomatis polymorphic membrane proteins G
Louis Odinakaose Ezediuno,Olugbenga S Onile,E.K. Oladipo,Olusola Nathaniel Majolagbe,Esther Moradeyo Jimah,Tosin Yetunde Senbadejo +5 more
TL;DR: In this paper, a combination of bioinformatics and immunoinformatics methods and tools were applied to design multi-epitope subunit vaccines using Chlamydia trachomatis polymorphic membrane protein G (PMPG).
Journal ArticleDOI
Proteomics approaches: A review regarding an importance of proteome analyses in understanding the pathogens and diseases
Muhammad Zubair,Jia Wang,Yanfei Yu,Muhammad Reza Faisal,Mingpu Qi,Abid Ullah Shah,Zhixin Feng,Guoqing Shao,Yu Wang,Qiyan Xiong +9 more
TL;DR: Proteomics is playing an increasingly important role in identifying pathogens, emerging and reemerging infectious agents, understanding pathogenesis, and diagnosis of diseases as discussed by the authors , and it is also helping in the identification of secreted proteins and their virulence-related functions.
Journal ArticleDOI
Recent Advances in Genomics-Based Approaches for the Development of Intracellular Bacterial Pathogen Vaccines
Muhammad Ajmal Khan,Aftab Amin,Awais Farid,Amin Ullah,Abdul Waris,Khyber Shinwari,Yaseen Hussain,Khalaf F. Alsharif,K. Alzahrani,Haroon Khan +9 more
TL;DR: A review of the evolution of vaccines can be found in this paper , where the authors highlight the key issues and explore the evolutionary process of vaccines, along with their characteristics, and the opportunities and obstacles involved.
Journal ArticleDOI
Prospect of using B. anthracis exotoxin in the design of anti-selective emergency preparations
TL;DR: In this article , the effect of B. anthracis exotoxins on the body was investigated by administering them to laboratory animals in different titres of exotoxin, followed by infection with the pathogenic strain B.anthracis 92 Z.
References
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Book ChapterDOI
Protein identification and analysis tools in the ExPASy server
Marc R. Wilkins,Elisabeth Gasteiger,Amos Marc Bairoch,Jean Emmanuel Sanchez,Keith L. Williams,Ron D. Appel,Denis Hochstrasser +6 more
TL;DR: Details are given about protein identification and analysis software that is available through the ExPASy World Wide Web server and the extensive annotation available in the Swiss-Prot database is used.
Journal ArticleDOI
Structure validation by Calpha geometry: phi,psi and Cbeta deviation.
Simon C. Lovell,Ian W. Davis,W. Bryan Arendall,Paul I.W. de Bakker,J. Michael Word,Michael G. Prisant,Jane S. Richardson,David S. Richardson +7 more
TL;DR: Geometrical validation around the Cα is described, with a new Cβ measure and updated Ramachandran plot, and Favored and allowed ϕ,ψ regions are also defined for Pro, pre‐Pro, and Gly (important because Gly ϕ‐ψ angles are more permissive but less accurately determined).
Journal ArticleDOI
Template-based protein structure modeling using the RaptorX web server
Morten Källberg,Morten Källberg,Haipeng Wang,Sheng Wang,Jian Peng,Zhiyong Wang,Hui Lu,Jinbo Xu +7 more
TL;DR: This protocol presents a community-wide web-based method using RaptorX (http://raptorx.uchicago.edu/) for protein secondary structure prediction, template-based tertiary structure modeling, alignment quality assessment and sophisticated probabilistic alignment sampling.
Journal ArticleDOI
Bioterrorism-related inhalational anthrax: the first 10 cases reported in the United States.
TL;DR: Clinical presentation and course of cases of bioterrorism-related inhalational anthrax, in the District of Columbia, Florida, New Jersey, and New York, are described; survival of patients was markedly higher than previously reported.
Journal ArticleDOI
PEP-FOLD3: faster de novo structure prediction for linear peptides in solution and in complex.
TL;DR: PEP-FOLD3 is a novel computational framework that allows both (i) de novo free or biased prediction for linear peptides between 5 and 50 amino acids, and (ii) the generation of native-like conformations of peptides interacting with a protein when the interaction site is known in advance.