Structure and function of the skeletal muscle extracellular matrix
Reads0
Chats0
TLDR
The structure, composition, and mechanical properties of skeletal muscle ECM are reviewed; the cells that contribute to the maintenance of the ECMAreas for future study are proposed; and overview changes that occur with pathology are described.Abstract:
The skeletal muscle extracellular matrix (ECM) plays an important role in muscle fiber force transmission, maintenance, and repair. In both injured and diseased states, ECM adapts dramatically, a property thathas clinical manifestations and alters muscle function. Here, we review the structure, composition, and mechanical properties of skeletal muscle ECM, describe the cells that contribute to the maintenance of the ECM and, finally, overview changes that occur with pathology. New scanning electron micrographs of ECM structure are also presented with hypotheses about ECM structure-function relationships. Detailed structure-function relationships of the ECM have yet to be defined and, as a result, we propose areas for future studies.read more
Citations
More filters
Journal ArticleDOI
Muscle-Inspired Self-Healing Hydrogels for Strain and Temperature Sensor.
Gang Ge,Yao Lu,Xinyu Qu,Wen Zhao,Yanfang Ren,Wenjun Wang,Qian Wang,Wei Huang,Wei Huang,Xiaochen Dong,Xiaochen Dong +10 more
TL;DR: Inspired by the fiber-reinforced microstructures and mechano-transduction systems of human muscles, a self-healing, long-lasting thermal tolerant and dual-sensory hydrogel-based sensor is proposed, with high gauge factor and a flexible touch keyboard for signature identification and a "fever indicator" for human forehead's temperature detection can be realized by this Hydrogel bioelectronic device.
Journal ArticleDOI
Collagen VI regulates satellite cell self-renewal and muscle regeneration
Anna Urciuolo,Marco Quarta,Valeria Morbidoni,Francesca Gattazzo,Sibilla Molon,Paolo Grumati,Francesca Montemurro,Francesco Tedesco,Bert Blaauw,Giulio Cossu,Giovanni Vozzi,Thomas A. Rando,Paolo Bonaldo +12 more
TL;DR: It is shown that the extracellular matrix protein collagen VI is a key component of the satellite cell niche and establishes a critical role for an extracllular matrix molecule in satellite cell self-renewal and open new venues for therapies of collagen VI-related muscle diseases.
Journal ArticleDOI
The Horizon of Materiobiology: A Perspective on Material-Guided Cell Behaviors and Tissue Engineering
Yulin Li,Yin Xiao,Changsheng Liu +2 more
TL;DR: In this article, the authors systematically summarize the recent progress on how biomaterials with controllable properties (e.g., compositional/degradable dynamics, mechanical properties, 2D topography, and 3D geometry) can regulate cell behaviors and tissue/organ functions.
Journal ArticleDOI
Bringing cultured meat to market: Technical, socio-political, and regulatory challenges in cellular agriculture
Neil Stephens,Lucy Di Silvio,Illtud Dunsford,Marianne J. Ellis,Abigail Glencross,Alexandra E. Sexton +5 more
TL;DR: Cultured meat is a promising, but early stage, technology with key technical challenges including cell source, culture media, mimicking the in-vivo myogenesis environment, animal-derived and synthetic materials, and bioprocessing for commercial-scale production.
Journal ArticleDOI
Nanotopography-guided tissue engineering and regenerative medicine ☆
Hong Nam Kim,Alex Jiao,Nathaniel S. Hwang,Min Sung Kim,Do Hyun Kang,Deok Ho Kim,Kahp-Yang Suh +6 more
TL;DR: An extensive analysis of recent efforts to mimic functional nanostructures in vitro for improved tissue engineering and regeneration of injured and damaged tissues shows that the nanotopography itself can activate tissue-specific function in vitro as well as promote tissue regeneration in vivo upon transplantation.
References
More filters
Journal ArticleDOI
Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
Journal ArticleDOI
Transforming growth factor beta in tissue fibrosis.
Wayne A. Border,Nancy A. Noble +1 more
TL;DR: A large number of patients with progressive fibrosis have no known underlying cause of disease and the prognosis is poor, suggesting that the disease is likely to get worse as they age.
Journal ArticleDOI
Fatty muscle degeneration in cuff ruptures. Pre- and postoperative evaluation by CT scan
TL;DR: A preoperative computed tomography scan grading muscular fatty degeneration in five stages was done in 63 patients scheduled for repair of a torn rotator cuff, finding that infraspinatus degeneration had a highly negative influence on the outcome of suprasp inatus repairs.
Journal ArticleDOI
TGF-beta signaling and the fibrotic response.
Andrew Leask,David Abraham +1 more
TL;DR: The current state of knowledge concerning interactions among the profibrotic proteins transforming growth factor‐β (TGF‐β), connective tissue growth factor (CTGF, CCN2), and ED‐A fibronectin (ED‐A FN) and the antifib rotic proteins tumor necrosis factor‐α (TNF‐α) and γ‐interferon (IFN‐γ) is discussed.
Journal ArticleDOI
Collagens—structure, function, and biosynthesis
TL;DR: The importance of different collagen types not only for the understanding of collagen-related diseases, but also as a basis for the therapeutical use of members of this protein family discussed in other chapters of this issue is indicated.