Structure of replicating SARS-CoV-2 polymerase.
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Cites background from "Structure of replicating SARS-CoV-2..."
...For example, the non-replicating Ad5 vectored COVID-19 vaccine produced by CanSino Biologics lnc, the mRNA-1273 COVID-19 vaccine developed by Moderna, the DNA vaccine of Inovio Pharmaceuticals, the BioNTech’s mRNA COVID-19 vaccine, the vaccine ChAdOx1 nCoV-19 of University of Oxford (Zhu et al., 2020), the adenovirus serotype 26 vector-based vaccine Ad26....
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...Residues D623, S682, and N691 are likely to interacts with the 2’-OH group of the triphosphate (NTP), making the RdRp special for the synthesis of RNA instead of DNA (Hillen et al., 2020)....
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...DNA vaccines targets the spike protein of SARSCoV-2....
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...At week 0 and week 3, rhesus macaques were injected 5 mg DNA vaccines intramuscularly....
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...DNA Vaccines A recent study (Yu J. et al., 2020) has produced a series of DNA vaccine candidates which express six variants of the spike protein of the SARS-CoV-2....
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Cites background or methods from "Structure of replicating SARS-CoV-2..."
...3 Å resolution (Figure S4B), including the nsp8 N-terminal extensions that interact with the upstream duplex RNA and the complete NiRAN domain (Hillen et al., 2020; Wang et al., 2020)....
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...The measured mass for the holo-RdRp:RNA complex corroborates the established stoichiometry of 1:2:1:1 for nsp7:nsp8:nsp12:RNA (Hillen et al., 2020; Kirchdoerfer and Ward, 2019; Wang et al., 2020; Yin et al., 2020), respectively (bottom)....
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...For initial model of the nsp132-RTC, the initial RTCmodel was derived from PDB:6YYT (Hillen et al., 2020) and the initial nsp13model from PDB:6JYT (Jia et al., 2019)....
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...Model building and refinement For initial model of the nsp132-RTC, the initial RTCmodel was derived from PDB:6YYT (Hillen et al., 2020) and the initial nsp13model from PDB:6JYT (Jia et al....
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References
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