Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis.
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...The helical domain may also contribute to the effector-binding site (Coleman et al., 1994), along with other regions on the GTPase domain (see below)....
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...A new era in understanding the structural basis for cz subunit function opened when the crystal structure of GTP-and GDP-liganded transducin and ml was solved (Noel et al., 1993; Lambright et al., 1994; Coleman et al., 1994)....
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...The first 25 amino acids of the ~ subu nit are essential for 13y binding (Fung and Nash, 1983; Denker et al., 1992a), but their position is unknown because they are mobile and do not show in the crystal (Coleman et al., 1994)....
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