Studien über pathogene Staphylokokken in südosteuropäischen und mediterranen geographischen Einheiten
TL;DR: In this paper, an geographisch und milieumasig geeignetem Material gezeigt, das in Sudosteuropa in landlichen Gebieten keine penicillinresistenten Staphylokokken vorkommen, and das dagegen in Grosstadten, vor allem im Krankenhausmilieu dieselben hohen Prozentsatze zu finden sind, wie sie von englischen Autoren fur die dortigen ents
Abstract: Es wird an geographisch und milieumasig geeignetem Material gezeigt, das in Sudosteuropa in landlichen Gebieten keine penicillinresistenten Staphylokokken vorkommen, das dagegen in Grosstadten, vor allem im Krankenhausmilieu dieselben hohen Prozentsatze zu finden sind, wie sie von englischen Autoren fur die dortigen entsprechenden Verhaltnisse gefunden wurden. Ebenso wird eine eingehende Analyse der resistenten Mikrokokken aus denselben Gegenden und Verhaltnissen gebracht. Es zeigt sich, das die Verteilung der resistenten Stamme ganz anders ist, als bei den Staphylokokken. Die Grunde dafur werden untersucht.
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TL;DR: Self-Infection in Carriers and Lesions, Cross-In infection from Carriers, Changes in carrier rate with age, and persistence of nasal carriage in different population groups are studied.
Abstract: Frequency of Carriage in Different Parts of the Body........................................... Nasal Carriage.............................................................................. Location of carriage within the nose......................................................... Frequency of nasal carriage in different population groups.................................... Changes in carrier rate with age............................................................. Carriage by hospital patients and personnel................................................. Acquisition by newborn infants.............................................................. Persistence of nasal carriage............................................................... Throat Carriage............................................................................. Skin Carriage............................................................................... Intestinal Carriage.......................................................................... HARMFUL CARRIAGE. .. ....................................................................... Phage Types of Staphylococci from. Carriers and Lesions ........................................ Self-Infection in Carriers .................................................................... Cross-Infection from Carriers ................................................................. CONCLUSION.................................................................................... LITERATURE CITED...............
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TL;DR: In this paper, the Stratum corneum kunstlich weitgehend beraubte Hautoberflache erweist sich im Gegensatz zur unversehrten Epidermis als relativ abwehrschwaches and als Nahrsubstrat offenbar verwertbares Gewebe.
Abstract: Die des Stratum corneum kunstlich weitgehend beraubte Hautoberflache erweist sich im Gegensatz zur unversehrten Epidermis als relativ abwehrschwaches und als Nahrsubstrat offenbar verwertbares Gewebe. Unter Okklusivverband setzt eine bereits nach 2 Std nachzuweisende Vermehrung ein, die in der Folgezeit rasch hohe Endkeimzahlen bewirkt; makroskopisch-klinisch resultieren nach 24 Std, starker ausgepragt nach 48 und 72 Std, entzundliche Veranderungen in Form von Papeln, Papulovesikeln bis zu flachenhaftem Nassen. —Bei luftdurchlassiger Bedeckung der Versuchsfelder kommt es — im Gegensatz zur normalen Hautoberflache — zu einer vorubergehenden, geringen Vermehrung (24 Std-Werte) bei einem Teil der Probanden. Im weiteren Verlauf wird auch hier die Tendenz zur — wenngleich entsprechend langsamer erreichten — Elimination des Testkeims deutlich; der verimpfte Staphylococcus aureus konnte 72 Std nach Einsaat bei knapp der Halfte der Versuchspersonen nicht mehr nachgewiesen werden.
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Journal Article•
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TL;DR: Experience with a large number of tests has indicated that the zones of inhibition obtained with the discs are more consistent and more sensitive to variations in the penicillin content of the sample than the zones obtained in the Oxford cup method.
Abstract: At the present time biological assay methods are the sole means of determining penicillin potency. A number of such methods are in use in various laboratories;1 however, the Oxford cup method,2 with several modifications,3 has continued to be regarded as a procedure in which a commensurate accuracy and speed may be obtained with a minimum of labor. The following filter paper disc modification should reduce the labor and time involved in setting up this test, while the case with which extra replicates may be run should increase the test's accuracy.The principal modification lies in the use of a thick filter paper disc saturated with the penicillin sample, substituted for the sample-containing small cylinder used in the Oxford cup method. These discs may be conveniently set up on the seeded plates at a rate of about 6 per minute, a rate considerably more rapid than that in the original method. Another advantage of the discs is that the test plates may be manipulated freely to facilitate reading. Experience ...
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TL;DR: The ballet dancer, aged 46, died quietly of cardiac secondaries from cancer of the cervix uteri after two injections of 40 ml.
Abstract: incapacitated with pain for three months-was able to return to his work as a milk-roundsman for the rest of his life (nearly seven months) and die easily of a haemorrhage. He needed only one injection of 50 ml. of proctocaine. The ballet dancer, aged 46, died quietly of cardiac secondaries from cancer of the cervix uteri after two injections of 40 ml. of proctocaine, the second injection being fortified with 5 ml. of absolute alcohol, nine weeks after her first visit to us. The duration of relief with one to three injections varied in 11 others from three weeks to four months; in all but four this marked their natural term. The four developed painful secondaries in other regions, and one of them had a neurectomy for this reason. One other, a tough Welsh miner of wonderful physique with extensive invasion of the abdominal wall by a cancer of the bladder, died apparently from exhaustion and haemorrhage under thiopentone anaesthesia, given before attempting the caudal injection, as in no other way could the unfortunate man bear being turned on his side. This was our only disaster. Necropsy was refused, so that oil embolism could not be ruled out as the immediate cause of the sudden death shortly after the caudal injection was begun. He had suffered-hideous pain for some weeks before. Two women with pelvic secondaries from uterine cancer had apparently complete relief for a few days after injection, but on return of symptoms failed to be relieved by further injection. In one, intestinal obstruction by secondaries was proved at necropsy; in the other, massive abdominal and pulmonary secondaries proved fatal under opiates. One man with prostatic cancer was not relieved at all; radiography had revealed spinal metastases, and he was kept under morphine for the few weeks left. I have not observed or been told of any urinary or faecal incompetence following caudal injection of proctocaine, with or without added alcohol, in any of. the patients treated.
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