Journal ArticleDOI
Studies on Coumarins and Coumarin-Related Compounds to Determine their Therapeutic Role in the Treatment of Cancer
Aoife Lacy,Richard O'Kennedy +1 more
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TLDR
These studies suggest that both genistein and esculetin exerted the most potent inhibitory effect on cell growth in comparison to the other two compounds, which may lead to its use in cancer therapy.Citations
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A Review of Coumarin Derivatives in Pharmacotherapy of Breast Cancer
TL;DR: The objective of this review is to focus on important coumarin analogs with antibreast cancer activities, highlight their mechanisms of action and structure-activity relationships on selected receptors in breast tissues, and the different methods that have been applied in the construction of these pharmacologically important cou Marlin analogs.
Journal ArticleDOI
Natural and synthetic chromenes, fused chromenes, and versatility of dihydrobenzo[h]chromenes in organic synthesis.
Ramendra Pratap,Vishnu Ji Ram +1 more
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Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds
TL;DR: An overview of the most recent synthetic pathways leading to mono- and polyfunctionalized coumarins will be presented, along with the main biological pathways of their biosynthesis and metabolic transformations.
Journal ArticleDOI
Coumarin heterocyclic derivatives: chemical synthesis and biological activity
Fernanda G. Medina,Joaquín G. Marrero,Mariana Macías-Alonso,Magdalena C. Gonzalez,Iván Córdova-Guerrero,Ariana G. Teissier Garcia,Soraya Osegueda-Robles +6 more
TL;DR: This review highlights the broad range of science that has arisen from the synthesis of coumarin-linked and fused heterocycle derivatives and their synthesis and biological activity.
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Bioactivities of Phenolics by Focusing on Suppression of Chronic Diseases: A Review
Fereidoon Shahidi,JuDong Yeo +1 more
TL;DR: This review provides crucial information for better understanding the bioactivities of phenolics in foods and fills a gap in the existing collective and overall knowledge in the field.
References
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Journal ArticleDOI
Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells.
Anna Rita Migliaccio,M. Di Domenico,Gabriella Castoria,A. de Falco,Paola Bontempo,E. Nola,Ferdinando Auricchio +6 more
TL;DR: Estradiol activates the tyrosine kinase/p21ras/MAP‐kinase pathway in MCF‐7 cells with kinetics which are similar to those of peptide mitogens and this finding proves that the classic estradiol receptor is responsible for the transduction pathway activation.
Journal ArticleDOI
Estrogen action via the camp signaling pathway : stimulation of adenylate cyclase and camp-regulated gene transcription
TL;DR: These findings document a nongenomic action of estrogenic hormones that involves the activation of an important second-messenger signaling system and suggest that estrogen regulation of cAMP may provide an additional mechanism by which this steroid hormone can alter the expression of genes.
Journal Article
Estrogenic Effects of Genistein on the Growth of Estrogen Receptor-positive Human Breast Cancer (MCF-7) Cells in Vitro and in Vivo
TL;DR: Dietary genistein can act as an estrogen agonist in vivo and in vitro, resulting in the proliferation of cultured human breast cancer cells (MCF-7) and the induction of pS2 gene expression.
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Pharmacological and biochemical actions of simple coumarins : Natural products with therapeutic potential
J. R. S. Hoult,Miguel Payá +1 more