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Journal ArticleDOI

Studies on hepatoprotective and antioxidant actions of Strychnos potatorum Linn. seeds on CCl4-induced acute hepatic injury in experimental rats.

21 Apr 2006-Journal of Ethnopharmacology (Elsevier)-Vol. 105, Iss: 1, pp 154-160
TL;DR: Reduced enzymic and nonenzymic antioxidant levels and elevated lipid peroxide levels were restored to normal by administration of SPP and SPE, and Histopathological studies further confirmed the hepatoprotective activity of SPE when compared with the CCl4 treated control groups.
About: This article is published in Journal of Ethnopharmacology.The article was published on 2006-04-21. It has received 113 citations till now. The article focuses on the topics: Strychnos potatorum & Lipid peroxide.
Citations
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Journal ArticleDOI
TL;DR: Beneficial effects on pancreatic tissues subjected to STZ-induced oxidative stress by directly quenching lipid peroxides and indirectly enhancing production of endogenous antioxidants are shown.
Abstract: The present study was undertaken to investigate the leaf aqueous extract effects of Annona muricata Linn. on the morphology of pancreatic β-cells and oxidative stress induced by streptozotocin (STZ)-diabetic rats. Diabetes mellitus was induced in the diabetic animal groups B and C by intraperitoneal injections of STZ (75 mg/kg body weight), while the control group received equal volume of citrate buffer (pH 6.3) solution intraperitoneally. The rats in group C were given A. muricata leaf aqueous extract (AME, 100 mg/kg, p.o.) as from day 5 post STZ injections, and stopped on the 30th day of the study period. The pancreases of the rats were excised and randomly processed for histological staining and biochemical assays for antioxidant enzymes [such as glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), malondialdehyde (MDA) and serum nitric oxide (NO)]. In diabetic state, pancreatic β-cells of STZ-treated group B rats histologically demonstrated marked alterations in the micro-anatomy and cellular integrities. The morphology of A. muricata-treated rats’ pancreases showed viable cellularity with distinct β-cell mass. STZ treatment significantly decreased GSH-Px, SOD, GSH, CAT and pancreatic/serum insulin levels (p treatment increased blood glucose concentrations, MDA, and NO. A. muricatatreated rats showed a significant decrease (p beneficial effects on pancreatic tissues subjected to STZ-induced oxidative stress by directly quenching lipid peroxides and indirectly enhancing production of endogenous antioxidants. Annona muricata protected and preserved pancreatic β- cell integrity. (Afr. J. Biomed. Res. 9: 173 - 180 Keywords: Annona muricata Leaf Aqueous Extract; morphological Changes; Oxidative Stress; Antioxidants.

125 citations

Journal ArticleDOI
TL;DR: Biological evidence that supports the use of RJ in the treatment of chemical-induced hepatotoxicity is revealed, resulting in reduced lipid peroxidation and improved endogenous antioxidant defence systems.

115 citations


Cites background from "Studies on hepatoprotective and ant..."

  • ...Furthermore, some studies revealed that natural products, containing antioxidant, protect the liver against lipid peroxidation and impairment in antioxidant status induced by CCl4 (Shaker et al., 2010; Sanmugapriya and Venkataraman, 2006)....

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  • ...Recent studies have shown that following CCl4 toxicity, MDA levels increase in blood or tissues; but, administration of antioxidant agent significantly decreases its level (Noyan et al., 2006; Sanmugapriya and Venkataraman, 2006; Kanter et al., 2003)....

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Journal ArticleDOI
TL;DR: SPP and SPE showed reduction in rat paw edema volume and it could significantly normalize the haematological and biochemical abnormalities in adjuvant induced arthritic rats in both developing and developed phases of FCA induced arthritis.
Abstract: Strychnos potatorum Linn (Loganiaceae) is a moderate sized tree found in southern and central parts of India, Sri Lanka and Burma. In traditional system of medicine, Strychnos potatorum Linn seeds were used for various ailments including inflammation, diabetes etc. To investigate the folkloric use of the seeds the present study was carried out on Freund's adjuvant induced arthritic rats. The present study states the effect of the aqueous extract (SPE) and the whole seed powder (SPP) of Strychnos potatorum Linn seeds on the Freund's complete adjuvant (FCA) induced arthritic rat paw edema, body weight changes and alterations in haematological and biochemical parameters in both developing and developed phases of arthritis. Histopathology of proximal interphalangeal joints and radiology of hind legs were studied. In FCA induced arthritic rats, there was significant increase in rat paw volume and decrease in body weight increment, whereas SPP and SPE treated groups, showed significant reduction in paw volume and normal gain in body weight. The altered haematological parameters (Hb, RBC, WBC and ESR) and biochemical parameters (blood urea, serum creatinine, total proteins and acute phase proteins) in the arthritic rats were significantly brought back to near normal by the SPP and SPE treatment at the dose of 200 mg/kg/p.o in both developing and developed phases of arthritis. Further the histopathological and radiological studies revealed the antiarthritic activity of SPP and SPE by indicating fewer abnormalities in these groups when compared to the arthritic control group. In conclusion, both SPP and SPE at the specified dose level of 200 mg/kg, p.o. showed reduction in rat paw edema volume and it could significantly normalize the haematological and biochemical abnormalities in adjuvant induced arthritic rats in both developing and developed phases of FCA induced arthritis. Further the histopathological and radiological studies confirmed the antiarthritic activity of SPP and SPE.

107 citations


Cites background from "Studies on hepatoprotective and ant..."

  • ...various activities like antidiabetic [9], antihypercholesterolemic activity [10], diuretic [11], antidiarrhoeal [12], hepatoprotective [13] and antiulcer [14]....

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Journal ArticleDOI
TL;DR: Out of the several leads obtained from plant sources as potential hepatoprotective agents, silymarin, andrographolide, neoandrographlide, curcumin, picroside, kutkoside, phyllanthin, hypophyllanthin and glycyrrhizin have been established as potent hepatoprotsective agents.
Abstract: Context: Liver disease is a serious ailment and the scenario is worsened by the lack of precise therapeutic regimens. Currently available therapies for liver ailments are not apposite and systemic toxicity inhibits their long term use. Medicinal plants have been traditionally used for treating liver diseases since centuries as the toxicity factor appears to be on the lower side.Objective: Several phytochemials have been identified which have significant hepatoprotective activity with minimal systemic adverse effects which could limit their long term use. The scenario calls for extensive investigations which can lead to development of lead molecules for hepatoprotective molecules of future. This review deals with the biological activity, mode of action and toxicity and forthcoming application of some of these leads.Methods: These generally have strong antioxidative potential and cause induction of antioxidant enzymes like superoxide dismutase, reduced glutathione and catalase. Additional mechanisms of hepa...

102 citations

Journal ArticleDOI
TL;DR: Investigation of the protective effect and possible mechanism of aqueous extract from Phyllanthus amarus Schum and its possible mechanism confirmed the beneficial roles of PA and SL against ethanol-induced liver injury in rats, including their antioxidant activity.

101 citations

References
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Journal Article
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.

289,852 citations

Journal ArticleDOI
TL;DR: Using this method, the liped peroxide level in the liver of rats suffering from carbon tetrachloride intoxication was investigated and was in good agreement with previously reported data obtained by measuring diene content.

24,847 citations

Journal ArticleDOI
TL;DR: The autoxidation of pyrogallol was investigated in the presence of EDTA in the pH range 7.9–10.6, indicating an almost total dependence on the participation of the superoxide anion radical, O2·−, in the reaction.
Abstract: The autoxidation of pyrogallol was investigated in the presence of EDTA in the pH range 7.9–10.6. The rate of autoxidation increases with increasing pH. At pH 7.9 the reaction is inhibited to 99% by superoxide dismutase, indicating an almost total dependence on the participation of the superoxide anion radical, O2·−, in the reaction. Up to pH 9.1 the reaction is still inhibited to over 90% by superoxide dismutase, but at higher alkalinity, O2·− -independent mechanisms rapidly become dominant. Catalase has no effect on the autoxidation but decreases the oxygen consumption by half, showing that H2O2 is the stable product of oxygen and that H2O2 is not involved in the autoxidation mechanism. A simple and rapid method for the assay of superoxide dismutase is described, based on the ability of the enzyme to inhibit the autoxidation of pyrogallol. A plausible explanation is given for the non-competitive part of the inhibition of catechol O-methyltransferase brought about by pyrogallol.

9,030 citations

Book
09 Jan 2018
TL;DR: Indian medicinal plants/, Indian medicinal plants /, مرکز فناوری اطلاعات و اصاع رسانی, کδاوρزی
Abstract: Indian medicinal plants / , Indian medicinal plants / , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی

8,252 citations

Book
01 Jan 1973
TL;DR: In this article, the authors present methods of extraction and isolation of plant components and methods of separation, and methods for identification and analysis of the results of the extraction and separation of these components.
Abstract: 1 Methods of Plant Analysis.- 1.1 Introduction.- 1.2 Methods of extraction and isolation.- 1.3 Methods of separation.- 1.4 Methods of identification.- 1.5 Analysis of results.- 1.6 Applications.- 2 Phenolic Compounds.- 2.1 Introduction.- 2.2 Phenols and phenolic acids.- 2.3 Phenylpropanoids.- 2.4 Flavonoid pigments.- 2.5 Anthocyanins.- 2.6 Flavonols and flavones.- 2.7 Minor flavonoids, xanthones and stilbenes.- 2.8 Tannins.- 2.9 Quinone pigments.- 3 The Terpenoids.- 3.1 Introduction.- 3.2 Essential oils.- 3.3 Diterpenoids and gibberellins.- 3.4 Triterpenoids and steroids.- 3.5 Carotenoids.- 4 Organic Acids, Lipids and Related Compounds.- 4.1 Plant acids.- 4.2 Fatty acids and lipids.- 4.3 Alkanes and related hydrocarbons.- 4.4 Polyacetylenes.- 4.5 Sulphur compounds.- 5 Nitrogen Compounds.- 5.1 Introduction.- 5.2 Amino acids.- 5.3 Amines.- 5.4 Alkaloids.- 5.5 Cyanogenic glycosides.- 5.6 Indoles.- 5.7 Purines, pyrimidines and cytokinins.- 5.8 Chlorophylls.- 6 Sugars and their Derivatives.- 6.1 Introduction.- 6.2 Monosaccharides.- 6.3 Oligosaccharides.- 6.4 Sugar alcohols and cyclitols.- 7 Macromolecules.- 7.1 Introduction.- 7.2 Nucleic acids.- 7.3 Proteins.- 7.4 Polysaccharides.

8,090 citations