Journal ArticleDOI
Studies on the anticlastogenic effect of turmeric and curcumin on cyclophosphamide and mitomycin C in vivo.
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TLDR
Although curcumin is reported to be the active chemopreventive principle in turmeric effective against a number of potential carcinogens in several experimental systems, it was virtually ineffective against the clastogenicity of CP or MMC at the doses tested.About:
This article is published in Food and Chemical Toxicology.The article was published on 1998-01-01. It has received 32 citations till now. The article focuses on the topics: Curcumin & Chromosome aberration.read more
Citations
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Biological Properties of Curcumin-Cellular and Molecular Mechanisms of Action
TL;DR: The most detailed studies using curcumin include anti-inflammatory, antioxidant, anticarcinogenic, antiviral, and antiinfectious activities as discussed by the authors, and wound healing and detoxifying properties have also received considerable attention.
Journal ArticleDOI
Updated recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests.
David Kirkland,Peter Kasper,Hans Jörg Martus,Lutz Müller,Jan van Benthem,Federica Madia,Raffaella Corvi +6 more
TL;DR: Three recommended lists of chemicals that would be appropriate to evaluate the sensitivity and specificity of new/modified mammalian cell genotoxicity tests are updated and how these should be used for any test evaluation program is described.
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Effects of the antioxidants curcumin and vitamin C on cisplatin-induced clastogenesis in Wistar rat bone marrow cells
Lusânia Maria Greggi Antunes,Maria Cristina Picinato Medeiros de Araújo,Joana D'Arc Castania Darin,Maria de Lourdes Pires Bianchi +3 more
TL;DR: Under the present experimental conditions, CMN could prevent cisplatin-induced clastogenesis by acting as a free radical scavenger and the combination between antioxidants would not be effective in protecting against cisplatin-induced chromosomal damage in animals sacrificed 24 h after cisPlatin treatment.
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Antimutagenic properties of bell and black peppers.
TL;DR: The results showed that bell pepper was effective in reducing the mutational events induced by EC and MMS and black pepper was only effective against EC.
Journal ArticleDOI
Potentiation by turmeric and curcumin of gamma-radiation-induced chromosome aberrations in Chinese hamster ovary cells.
TL;DR: The results clearly indicate the exacerbated effect of turmeric and curcumin on radiation-induced clastogenicity, suggesting that these antioxidants are also potentiating agents depending on the experimental conditions.
References
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Book
Indian Medicinal Plants
TL;DR: Indian medicinal plants/, Indian medicinal plants /, مرکز فناوری اطلاعات و اصاع رسانی, کδاوρزی
Journal Article
Chemoprevention of Colon Carcinogenesis by Dietary Curcumin, a Naturally Occurring Plant Phenolic Compound
TL;DR: Investigation of the chemopreventive action of dietary curcumin on azoxymethane-induced colon carcinogenesis and also the modulating effect of this agent on the colonic mucosal and tumor phospholipase A2, phospholIPase C gamma 1, lipoxygenase, and cyclo oxygengenase activities in male F344 rats indicates that dietary administration ofCurcumin significantly inhibited incidence of colon adenocarcinomas.
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Primary mutagenicity screening of food additives currently used in Japan
TL;DR: Salmonella/microsome tests (Ames tests) and chromosomal aberration tests in vitro using a Chinese hamster fibroblast cell line were carried out on 190 synthetic food additives and 52 food additives derived from natural sources, all of which are currently used in Japan.