Studies on the anticlastogenic effect of turmeric and curcumin on cyclophosphamide and mitomycin C in vivo.
TL;DR: Although curcumin is reported to be the active chemopreventive principle in turmeric effective against a number of potential carcinogens in several experimental systems, it was virtually ineffective against the clastogenicity of CP or MMC at the doses tested.
About: This article is published in Food and Chemical Toxicology.The article was published on 1998-01-01. It has received 32 citations till now. The article focuses on the topics: Curcumin & Chromosome aberration.
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01 Jan 2012
TL;DR: This bibliographic review aimed to indicate the main mutagenic and carcinogenic agents to that human may be exposed to, facing to alert population about health care.
Abstract: 1 RESUMO Este estudo teve como objetivo indicar os principais agentes mutagenicos e carcinogenicos aos quais o homem pode estar exposto, a fim de alertar a populacao para a prevencao de sua saude. Trata-se de artigo de revisao bibliografica. O homem esta exposto, no seu dia a dia, a inumeras substâncias biologicas, fisicas e quimicas, sinteticas ou naturais. Algumas dessas substâncias podem causar alteracoes no material genetico (DNA), resultando em mutacoes. A ingestao de alimentos e uma das principais vias de exposicao do homem a diferentes compostos mutagenicos/carcinogenicos, visto que uma mistura complexa de agentes quimicos e encontrada em sua dieta. Alem da alimentacao, outros fatores de risco podem resultar em mutacoes e/ou câncer, ligados ao estilo de vida, como o habito de fumar, ingestao de bebidas alcoolicas, a exposicao ocupacional a agentes quimicos, como os medicamentos, e aos fisicos, como a radiacao solar. Neste sentido, conhecer os possiveis agentes mutagenicos/carcinogenicos aos quais o homem esta exposto diariamente pode ajudar a alertar a populacao para uma mudanca dos habitos de vida e de comportamento. ABSTRACT This bibliographic review aimed to indicate the main mutagenic and carcinogenic agents to that human may be exposed to, facing to alert population about health care. Human is exposed in its day-to-day to numerous biological, physical and chemical substances of synthetic or natural origin. Some of these substances may cause changes in genetic material (DNA), resulting in mutations. Food intake is the major route of human exposure to mutagenic/carcinogenic different compounds, since a complex mixture of chemicals is found in diet. Besides food, other risk factors related to lifestyle may result in mutations and/or cancer such as smoking, alcohol intake, occupational exposure to chemicals (medicines) and physical agents (solar radiation). In this sense, know the mutagenic/carcinogenic agents to which human is daily exposed may help to alert the population to change its comportment and lifestyle.
01 Jan 2013
TL;DR: It is concluded that curcumin shows both genotoxicity and antigenotoxicity in a dosedepending manner.
Abstract: The present study aimed to evaluate the antigenotoxic activity of curcumin, a yellow colouring agent, contained in turmeric (Curcuma longa L., Zingiberaceae) on male rats. Curcumin possesses anti-inflammatory and antioxidant properties, therefore, it has been extensively investigated for its cancer chemopreventive potential. Eighty Swiss albino male allocated in several groups treated with methotrexate (MTX, 10 mg/ kg b.w.) and/or Curcumin (0.5, 10 and 25 mg/kg b.w). Random amplified polymorphic DNA polymerase chain reaction (RAPD-PCR) was used to determine the genetic damage in rats due to MTX and/or Curcumin treatment. Twinty random 10-nucleotide primers were used to determine the DNA damage and to perform the genotoxic and antimutagenic activity of the curcumin. Results showed that treatment of rats with low dose of curcumin alone did not induce any genotoxic effects. Supplementation of MTX treated-rats with 0.5 mg/kg bw of the curcumin reduced the DNA induced by MTX. However, continuous treatments with 10 and 25 mg/kg b.w. of curcumin induced DNA damage either alone or in combination with MTX treatment. Based on these findings we conclude that curcumin shows both genotoxicity and antigenotoxicity in a dosedepending manner.
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Book•
09 Jan 2018
TL;DR: Indian medicinal plants/, Indian medicinal plants /, مرکز فناوری اطلاعات و اصاع رسانی, کδاوρزی
Abstract: Indian medicinal plants / , Indian medicinal plants / , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
8,252 citations
831 citations
Journal Article•
TL;DR: Investigation of the chemopreventive action of dietary curcumin on azoxymethane-induced colon carcinogenesis and also the modulating effect of this agent on the colonic mucosal and tumor phospholipase A2, phospholIPase C gamma 1, lipoxygenase, and cyclo oxygengenase activities in male F344 rats indicates that dietary administration ofCurcumin significantly inhibited incidence of colon adenocarcinomas.
Abstract: Human epidemiological and laboratory animal model studies have suggested that nonsteroidal antiinflammatory drugs reduce the risk of development of colon cancer and that the inhibition of colon carcinogenesis is mediated through the alteration in cyclooxygenase metabolism of arachidonic acid. Curcumin, which is a naturally occurring compound, is present in turmeric, possesses both antiinflammatory and antioxidant properties, and has been tested for its chemopreventive properties in skin and forestomach carcinogenesis. The present study was designed to investigate the chemopreventive action of dietary curcumin on azozymethaneinduced colon carcinogenesis and also the modulating effect of this agent on the colonic mucosal and tumor phospholipase A 2 , phospholipase Cγ1, lipoxygenase, and cyclooxygenase activities in male F344 rats. At 5 weeks of age, groups of animals were fed the control (modified AIN-76A) diet or a diet containing 2000 ppm of curcumin. At 7 weeks of age, all animals, except those in the vehicle (normal saline)-treated groups, were given two weekly s.c. injections of azoxymethane at a dose rate of 15 mg/kg body weight. All groups were continued on their respective dietary regimen until the termination of the experiment at 52 weeks after the carcinogen treatment. Colonic tumors were evaluated histopathologically. Colonic mucosa and tumors were analyzed for phospholipase A 2 , phospholipase Cγ1, ex vivo prostaglandin (PG) E 2 , cyclooxygenase, and lipoxygenase activities. The results indicate that dietary administration of curcumin significantly inhibited incidence of colon adenocarcinomas ( P P P P 57% compared to the control diet. Animals fed the curcumin diet showed decreased activities of colonic mucosal and tumor phospholipase A 2 (50%) and phospholipase Cγ1 (40%) and levels of PGE 2 (>38%). The formation of prostaglandins such as PGE 2 , PGF 2α , PGD 2 , 6-keto PGF 1α , and thromboxane B 2 through the cyclooxygenase system and production of 5( S )-, 8( S )-, 12( S )-, and 15( S )-hydroxyeicosatetraenoic acids via the lipoxygenase pathway from arachidonic acid were reduced in colonic mucosa and tumors of animals fed the curcumin diet as compared to control diet. Although the precise mechanism by which curcumin inhibits colon tumorigenesis remains to be elucidated, it is likely that the chemopreventive action, at least in part, may be related to the modulation of arachidonic acid metabolism.
706 citations
TL;DR: Salmonella/microsome tests (Ames tests) and chromosomal aberration tests in vitro using a Chinese hamster fibroblast cell line were carried out on 190 synthetic food additives and 52 food additives derived from natural sources, all of which are currently used in Japan.
634 citations