Journal ArticleDOI
Studies on the antitumor activity of group VIII transition metal complexes. Part I. Platinum (II) complexes
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A wide variety of Platinum(II) complexes have been investigated for antitumor activity against Sarcoma 180 in Swiss white female mice as mentioned in this paper, and the results showed that only neutral complexes exhibit activity while charged species are inactive and relatively nontoxic.About:
This article is published in Bioinorganic Chemistry.The article was published on 1973-01-01. It has received 531 citations till now. The article focuses on the topics: Denticity & Cis–trans isomerism.read more
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The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs
TL;DR: Recently, there has been a surge of activity, based on a great deal of mechanistic information, aimed at developing nonclassical platinum complexes that operate via mechanisms of action distinct from those of the approved drugs as mentioned in this paper.
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Current status of platinum-based antitumor drugs.
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Metallodrugs in Medicinal Inorganic Chemistry
Katja Dralle Mjos,Chris Orvig +1 more
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Antitumour metal compounds: more than theme and variations.
Michael A. Jakupec,Markus Galanski,Vladimir B. Arion,Christian G. Hartinger,Bernhard K. Keppler +4 more
TL;DR: The recent achievement of oxaliplatin for the treatment of colon cancer should not belie the imbalance between a plethora of investigated complexes and a very small number of clinically approved platinum drugs as discussed by the authors.
Antitumour metal compounds: more than theme and variations
Michael A. Jakupec,Markus Galanski,Vladimir B. Arion,Christian G. Hartinger,Bernhard K. Keppler +4 more
TL;DR: The recent achievement of oxaliplatin for the treatment of colon cancer should not belie the imbalance between a plethora of investigated complexes and a very small number of clinically approved platinum drugs.
References
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Journal ArticleDOI
Platinum Compounds: a New Class of Potent Antitumour Agents
TL;DR: The platinum compounds inhibit sarcoma 180 and leukaemia L1210 in mice and reversibly inhibit cell division in Gram-negative rods1–4.
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The relative affinities of ligand atoms for acceptor molecules and ions
Journal Article
The Successful Regression of Large Solid Sarcoma 180 Tumors by Platinum Compounds
TL;DR: In this paper, the platinum compounds, cisplatinum (IV) diamminotetrachloride and cis-platinum diamminodichloride, have been reported to be active in inhibiting and regressing small solid Sarcoma 180 tumors and Leukemia L1210 tumors in mice.
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Inhibitory effects of anti-tumor platinum compounds on DNA, RNA and protein syntheses in mammalian cells in virtro.
TL;DR: A number of possible explanations for the greater sensitivity of DNA synthesis and the sequential inhibition of DNA, RNA and protein synthesis at higher concentrations are suggested.
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Cis-dichlorodiammineplatinum (II). Persistent and selective inhibition of deoxyribonucleic acid synthesis in vivo.
Jerry A. Howle,Glen R. Gale +1 more
TL;DR: It was suggested that if the persistent inhibitory action on DNA synthesis is directly related to the chemotherapeutic efficacy of this agent or a metabolic product thereof, a less frequent treatment regimen may be as effective as daily injections while evoking fewer toxic reactions.