Journal ArticleDOI
Studies on the regulation of the activity of drug oxidation in rat liver microsomes by androgen and estrogen
Kato Ryuichi,Onoda Kinichi +1 more
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TLDR
The results suggest that androgens increase the affinity of P-450 for the binding with substrates and estrogens directly counteract the action of androgen, consequently the alteration of the activities of drug oxidations may occur.About:
This article is published in Biochemical Pharmacology.The article was published on 1970-05-01. It has received 93 citations till now. The article focuses on the topics: Hexobarbital & Methyltestosterone.read more
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Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes
TL;DR: Key features of the cell signaling and molecular regulatory mechanisms by which sex-dependent plasma GH patterns impart sex specificity to the liver are discussed, which provide novel insights into the physiological regulation of both xenobiotic and endobiotic metabolism.
Journal ArticleDOI
Sex difference of cytochrome P-450 in the rat: purification, characterization, and quantitation of constitutive forms of cytochrome P-450 from liver microsomes of male and female rats.
TL;DR: Sex differences in drug metabolism in the rat were confirmed as explicable, at least in part, by the presence of distinct forms of cytochrome P-450 in microsomes of male and female rats.
Journal ArticleDOI
Drug metabolism under pathological and abnormal physiological states in animals and man.
TL;DR: The author recommends the use of female rats in the evaluation of the effects of pathological states on hepatic microsomal drug-metabolizing enzymes, as changes in activity of the hepatic enzymes reflect closely the changes in the rates of drug metabolism in vivo.
Journal ArticleDOI
Suppression of levels of phenobarbital-inducible rat liver cytochrome P-450 by pituitary hormone.
TL;DR: The results indicate that growth hormone acts as a repressive factor for the constitutive and inducible levels of P-450b and P- 450e in a manner different from the regulation ofP-450-male and P -450-female.
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Sex differences in cytochrome P-450 and mixed-function oxygenase activity in gonadally mature trout
TL;DR: Levels of microsomal cytochrome P-450 and aminopyrine demethylase activity in liver and in kidney of gonadally mature rainbow and brook trout were markedly greater in males than in females, suggesting sex-specific forms of cytochromes P- 450 of different catalytic function.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
Genetic regulatory mechanisms in the synthesis of proteins.
François Jacob,Jacques Monod +1 more
TL;DR: The synthesis of enzymes in bacteria follows a double genetic control, which appears to operate directly at the level of the synthesis by the gene of a shortlived intermediate, or messenger, which becomes associated with the ribosomes where protein synthesis takes place.
Journal ArticleDOI
The colorimetric estimation of formaldehyde by means of the Hantzsch reaction
TL;DR: A chronology of key events leading up to and including the birth of Bonnichsen, R. K. & Bonner, J. (1952).
Journal ArticleDOI
The Carbon Monoxide-binding Pigment of Liver Microsomes II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES
Tsuneo Omura,Ryo Sato +1 more
TL;DR: The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.
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Enzymatic metabolism of drugs and other foreign compounds.
Brodie Bb,Gillette,La Du Bn +2 more
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The Carbon Monoxide-binding Pigment of Liver Microsomes I. EVIDENCE FOR ITS HEMOPROTEIN NATURE
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