Studying the structural, morphological, and optical properties of CuS:Ni nanostructure prepared by a hydrothermal method for biological activity
TL;DR: In this paper, undoped and nickel (Ni)-doped copper sulfide nanostructures were synthesized using a hydrothermal method at 150°C for 15'h.
Abstract: In recent years, copper sulfide has attracted great interest in biological application, due to its biocompatibility and low toxicity. Undoped and nickel (Ni)-doped copper sulfide nanostructures were synthesized using a hydrothermal method at 150 °C for 15 h. XRD patterns show that all samples have confirmed the formation of a hexagonal phase. Absorbance spectra were measured by using a UV–vis spectrophotometer. The optical bandgap energy of CuS nanostructure decreased with increasing Ni doping concentration. Their optical bandgap energies were 3.2, 3.21, 2.9, and 2.9 eV for undoped and Ni-doped copper sulfide nanostructures with concentrations of 1, 3, and 5%, respectively. The antibacterial activity of CuS nanostructure against E. coli, P. aeruginosa, and S. aureus was evaluated by zone of inhibition. The test revealed that the minimum concentration of CuS nanostructure has a strong antibacterial activity against Gram-positive bacteria than for Gram-negative bacteria. Antitumor treatment was applied based on employing CuS nanostructures by exploiting their unique optical and morphological properties as therapeutic agents against rhabdomyosarcoma (RD) and murine fibroblast (L20B) cancer cell lines without using laser. The cytotoxicity effect was evaluated by MTT assay; the results demonstrated that CuS nanostructure with 1% Ni doping exhibits more toxicity effect than undoped and doped nanostructures, with 3 and 5% for all particle concentrations, where cytotoxicity reaches 34.3% at 0.125 mg/ml, being the most influential concentration, which could be a promising agent for cancer treatment.
Citations
More filters
TL;DR: In this article, un-doped and Nidoped titanium dioxide nanorod arrays were synthesized by using a hydrothermal method in a Teflon-lined autoclave, on a fluorine tin oxide (FTO) substrate, at different Ni content (XNi = 0, 0.025, 0., 0.075, and 0.1).
Abstract: In this work, un-doped and Ni-doped titanium dioxide nanorod (TiO2 NR) arrays were synthesized by using a hydrothermal method in a Teflon-lined autoclave, on a fluorine tin oxide (FTO) substrate, at different Ni content (XNi = 0, 0.025, 0.05, 0.075, and 0.1). The grown nanorod array samples were studied by XRD, FESEM, DC conductivity, Hall effect measurements, ultraviolet-visible (UV-Vis) spectroscopy, and vibrating-sample magnetometer (VSM) measurements. Pure rutile phase with preferred orientation along (002) was noticed, indicating that the vertical growth of nanorods for the un-doped sample converts to the (101) direction with increasing doping content. The sharp (002) peaks compared with the broad behavior for other peaks indicate the longitudinal growth along this direction. The lattice constant (a), for tetragonal structure, increased with increasing Ni content, while small increment showed along the (c) direction. Uniformly distributed nanorod arrays with 2000-nm length and 200-nm diameter for the un-doped sample. The nanorod length decreases and their diameters increase with increasing Ni doping content. All the prepared samples showed that they behave like n-type semiconductors with a high carrier concentration and this can be attributed to the present of oxygen vacancies. DC conductivity increases due to increasing carrier concentration, while the charge carriers’ mobility decreases with increasing doping content from 0 to 0.1. Increasing Ni content enhances the TiO2 NR magnetic properties, where the residual magnetization increased from 0.0001 to 0.0058 emu/g, while the saturation magnetization increased from 0.0304 to 0.2652 emu/g with increasing Ni content from 0 to 0.1.
10 citations
Additional excerpts
...It can be used to prepare large-scale aligned nanorod arrays [16], compared with other techniques, such as chemical bath deposition or SILAR methods, which cannot be used in fabrication of TiO2 nanorods [17]....
[...]
01 Jul 2021
TL;DR: In this article, the effect of adding the dopant concentration on the samples' structural, morphological, and optical characteristics were investigated, and the ultraviolet-visible-NIR spectrophotometer was used to investigate the optical properties.
Abstract: *Corresponding Author: Selma M. H. Al-Jawad Salma_aljawad@yahoo.com, 100069@uotechnology.edu.iq Abstract In this research, pure and 4%, Mn-doped thin films of cadmium sulfide (CdS) were synthesized using a 2-hour hydrothermal process. The effect of adding the dopant concentration on the samples' structural, morphological, and optical characteristics were investigated. The ultraviolet-visible-NIR spectrophotometer was used to investigate the optical properties. UV-Vis experiments lowered the optical bandgap with an add Mn percentage. Their optical bandgap was 2.38 eV for undoped thin films and 1.81 eV for 4% doped Mn-CdS thin films. UVVis spectroscopy data are in agreement with PL. FE-SEM imaging revealed morphological changes caused by the inclusion of Mn in CdS thin films. FE-SEM displays images of undoped CdS, which appear to be Nanoparticles. Morphology of the thin films has shown that the average grain size increases by the agglomeration of Nano-grains, which become clusters of particles after Mnincorporation. In addition, The XRD pattern revealed that prepared samples H (002)/C (111) as hexagonal and cube phases have a preferential orientation. The increase in the main diffraction peak (002) intensity with increasing Mn concentration revealed the substitution of Mn with Cd in the lattice. The crystallite size increased from10.74 to 11.67 nm with an Mn percentage.
8 citations
TL;DR: In this article, the effect of changing the dopant concentration on the structural, morphological and optical properties of the produced samples was investigated, and the surface morphology was studied using scanning electron microscopy and atomic force microscopy.
Abstract: Mn-CdS nanoflowers were successfully deposited using hydrothermal technique at 150 °C for 2 h. The effect of changing the dopant concentration on the structural, morphological and optical properties of the produced samples was investigated. The XRD diffraction technique showed the formation of hexagonal and cubic phases, whereas the FE-SEM analysis confirmed the success of the formation of flower-like nanostructures. The UV–Visible spectra revealed that the energy band-gap values decreased with increasing manganese concentrations. The optical band-gap ranges were 2.4, 2.35, 2.25, 2.14 and 1.76 eV thin films with concentrations of (0%, 1%, 2%, 3% and 4%) for undoped and Mn-doped cadmium sulfide. The results of UV–Vis spectroscopy agree with the conclusions of the PL study. The surface morphology was studied using scanning electron microscopy and atomic force microscopy. According to the results, the crystalline size decreased as doping concentrations increased. The Mn-doped cadmium sulfide films exhibited unprecedented photocatalytic activity for the decomposition of methyl blue (MB) and methyl violet (MV) dyes, due to high surface area, low energy gap and efficient charge separation properties for the prepared films.
8 citations
01 Jul 2021
TL;DR: Hussan et al. as mentioned in this paper characterized functionalized multi-walled carbon nanotubes (MWCNTs) by X-Ray Diffraction Analysis (XRD), Zeta potential and Field-Emission Scanning Electron Microscopy (FE-SEM).
Abstract: *Corresponding Author: Noor. Q. A. Hussan as.18.70@grad.uotechnology.edu.iq Abstract In the present study, the synthesized Multi-Walled Carbon Nanotubes (MWCNTs) were chemically treated with a mixture of acids to produce functionalized MWNTs. The functionalized MWCNTs were characterized by X-Ray Diffraction Analysis (XRD), Zeta potential and Field-Emission Scanning Electron Microscopy (FE-SEM). The X-ray diffraction reveals the MWCNTs average crystal size of the RMWCNTs and F-MWCNTs were about (3.27 and 3.19) nm, respectively. FESEM images show the formation of R-MWCNTs that appears as cylindrical tubes and aggregated tubes with each other, while the F-MWCNTs appear as less aggregated and tangled clusters than RMWCNTs. Zeta potential measurements showed that the measurement of the R-MWCNT shows a low negative value -9 mV and F-MWCNT, it was found that the zeta potential value is up to -29 mV. The antibacterial activity was studied against E. coli and P. aeruginosa bacteria, and indicated the highest growth inhibition zones (IZ) of FMWCNTs as compared with RMWCNTs against E. coli and Pseudomonas aeruginosa, respectively.
8 citations
TL;DR: In this article , the authors focused on copper sulfide (CuS) nanomaterials as efficient and cost-effective photodynamic therapy (PDT) and hyperthermia-based photothermal therapy (PTT) with antibacterial activity.
Abstract: Photo-stimuli-responsive therapeutic nanomaterials have gained widespread attention as frontline materials for biomedical applications. The photoactivation strategies are classified as single-modality (based on either reactive oxygen species (ROS)-based photodynamic therapy (PDT), hyperthermia-based photothermal therapy (PTT)), or dual-modality (which combines PDT and PTT). Due to its minimal invasiveness, phototherapy has been extensively applied as an efficient therapeutic platform for many diseases, including skin cancers. However, extensive implementation of phototherapy to address the emergence of multidrug-resistant (MDR) bacterial infections remains challenging. This review focuses on copper sulfide (CuS) nanomaterials as efficient and cost-effective PDT and PTT therapeutic nanomaterials with antibacterial activity. The features and merits of CuS nanomaterials as therapeutics are compared to those of other nanomaterials. Control of the dimensions and morphological complexity of CuS nanomaterials through judicious synthesis is then introduced. Both the in vitro antibacterial activity and the in vivo therapeutic effect of CuS nanomaterials and derivative nanocomposites composed of 2D nanomaterials, polymers, metals, metal oxides, and proteins are described in detail. Finally, the perspective of photo-stimuli-responsive CuS nanomaterials for future clinical antibacterial applications is highlighted. This review illustrates that CuS nanomaterials are highly effective, low-toxic, and environmentally friendly antibacterial agents or platform nanomaterials for combatting MDR bacterial infections.
5 citations
References
More filters
TL;DR: Graphene nanoparticles performed significantly better than CNT in inducing photothermal death of U251 human glioma cells in vitro and could be largely explained by their better dispersivity, which has been supported by a simple calculation.
499 citations
TL;DR: In this paper, the antimicrobial activity of ZnO nanoparticles against gram-negative and gram-positive bacteria was determined using bacteriological tests such as disc and well diffusion agar methods, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC).
Abstract: The aim of the present study is to determine the antimicrobial activity of ZnO nanoparticles against Gram-negative and Gram-positive bacteria Escherichia coli (E coli) and Staphylococcus aureus (S aureus) were used as test microorganisms The effects of particle size and concentration on the antibacterial activity of ZnO nanoparticles was studied using bacteriological tests such as disc and well diffusion agar methods, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) These tests were performed in nutrient broth and nutrient agar following standard methods In addition, the effect of different concentrations of ZnO nanoparticles on the growth of E coli and S aureus was measured with respect of time The minimum inhibitory concentration was determined using seven different concentrations of ZnO nanoparticles including 16, 8, 4, 2, 1 and 05 mg/ml The MIC value for E coli and S aureus was 1 and 05 mg/ml, respectively The results showed that ZnO nanoparticles have antibacterial inhibition zone of 29 and 19 mm at the concentration of 10 mg/ml against E coli and S aureus, respectively Gram-negative bacteria seemed to be more resistant to ZnO nanoparticles than Gram-positive bacteria It was found that the antibacterial activity of ZnO nanoparticles increased with decreasing particle size and increasing powder concentration The antibacterial effect of ZnO nanoparticles was time dependent and takes effect gradually ZnO bulk powder showed no significant antibacterial activity
Key word: ZnO nanoparticle, Escherichia coli, Staphylococcus aureus, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC)
362 citations
"Studying the structural, morphologi..." refers background in this paper
...area-to-volume ratio for a smaller particle is the reason for enhanced bioactivity of CuS [59, 60]....
[...]
TL;DR: Considering the low cost, easy preparation, excellent biocompatibility and strong photothermal convention efficiency, the BSA-CuS nanocomposites combined with NIR irradiation will shed bright light on the treatment of antibiotic-resistant pathogenic bacteria.
Abstract: Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) are the most common infectious bacteria in our daily life, and seriously affect human’s health. Because of the frequent and extensive use of antibiotics, the microbial strains forming drug resistance have become more and more difficult to deal with. Herein, we utilized bovine serum albumin (BSA) as the template to synthesize uniform copper sulfide (CuS) nanoparticles via a biomineralization method. The as-prepared BSA-CuS nanocomposites showed good biocompatibility and strong near-infrared absorbance performance and can be used as an efficient photothermal conversion agent for pathogenic bacteria ablation with a 980 nm laser at a low power density of 1.59 W/cm2. The cytotoxicity of BSA-CuS nanocomposite was investigated using skin fibroblast cells and displayed good biocompatibility. Furthermore, the antibacterial tests indicated that BSA-CuS nanocomposite showed no antibacterial activity without NIR irradiation. In contrast, they demonstrat...
160 citations
TL;DR: The suppressant effects of NN-B-4 on proliferation ofPBMC activated by PHA therefore appear to be mediated, at least in part, through inhibition of early transcripts of PBMC, especially those of important IL-2, IFN-gamma, and cdk4 and arrest of cell cycle progression in the cells.
160 citations
TL;DR: In this paper, the spin-coated monolayer of arachidic acid assembles on graphite as 1D nanostripes with bilayer periodicity and the copper arachidate film shows curved stripes, which become straight after reacting with hydrogen sulfide.
Abstract: We investigate the making of semiconductor nanorods using well-defined molecular templates. The films are characterized by AFM and XPS. The spin-coated monolayer of arachidic acid assembles on graphite as 1D nanostripes with bilayer periodicity. The copper arachidate film shows curved stripes, which become straight after reacting with hydrogen sulfide. The new template scheme may facilitate the fabrication of nanorod arrays of a variety of inorganic and semiconducting materials.
130 citations