Journal ArticleDOI
Subacute cadmium exposure promotes M1 macrophage polarization through oxidative stress-evoked inflammatory response and induces porcine adrenal fibrosis.
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In this article, the authors investigated the effect of Cd exposure on the porcine adrenal fibrosis by affecting the polarization of M1/M2 macrophages and its potential regulatory mechanism.About:
This article is published in Toxicology.The article was published on 2021-08-18. It has received 17 citations till now. The article focuses on the topics: Macrophage polarization & Fibrosis.read more
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TMT induces apoptosis and necroptosis in mouse kidneys through oxidative stress-induced activation of the NLRP3 inflammasome
TL;DR: In this paper , the effect of trimethyltin chloride (TMT) on mouse kidneys and its related mechanism were studied by taking TMT mouse with drinking water as a model, and the results showed that oxidative stress was activated (MDA,SOD,CAT,T-AOC), released ROS, activated NF-κB pathway,activated inflammasome (NLRP3,Caspase-1,ASC), and inflamma-secreted inflammatory factors (IL-1β).
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Cadmium exposure causes mitochondrial fission and fusion disorder in the pig hypothalamus via the PI3K/AKT pathway.
TL;DR: In this paper , the authors found that exposure to Cd inhibited PI3K and AKT, interfered with the balance of mitochondrial fusion and division, downregulated the expression of Mfn2, Mfn1, and OPA1, which led to cell apoptosis and programmed necrosis.
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Cadmium exposure activates the PI3K/AKT signaling pathway through miRNA-21, induces an increase in M1 polarization of macrophages, and leads to fibrosis of pig liver tissue.
TL;DR: In this article, the effects of subacute Cd exposure on pig liver fibrosis, as well as the polarization of microRNA (miRNA) and M1/M2 macrophages during this process were explored.
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Subacute Cadmium Exposure Induces Necroptosis in Swine Lung via Influencing Th1/Th2 Balance
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Di-(2-ethyl hexyl) phthalate induced oxidative stress promotes microplastics mediated apoptosis and necroptosis in mice skeletal muscle by inhibiting PI3K/AKT/mTOR pathway.
TL;DR: In this paper , the effects of DEHP/MPs alone and combined exposure on skeletal muscle cell injury in mice and the role of PI3K/AKT/mTOR axis remain unclear.
References
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Journal ArticleDOI
Macrophage plasticity, polarization, and function in health and disease.
Abbas Shapouri-Moghaddam,Saeed Mohammadian,Hossein Vazini,Mahdi Taghadosi,Seyed-Alireza Esmaeili,Fatemeh Mardani,Bita Seifi,Asadollah Mohammadi,Jalil Tavakol Afshari,Amirhossein Sahebkar +9 more
TL;DR: The protective and pathogenic role of the macrophage subsets in normal and pathological pregnancy, anti‐microbial defense, anti-tumor immunity, metabolic disease and obesity, asthma and allergy, atherosclerosis, fibrosis, wound healing, and autoimmunity are discussed.
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Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity.
TL;DR: IFN gamma activates human macrophage oxidative metabolism and antimicrobial activity, and appeared to be the only factor consistently capable of doing so in the diverse LK preparations tested.
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From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation
Paola Italiani,Diana Boraschi +1 more
TL;DR: This review will address some of the important questions under the general framework of the role of monocytes and macrophages in the initiation, development, resolution, and chronicization of inflammation.
Dataset
Mineral Commodity Summaries
TL;DR: The following topics are currently covered by the mineral commodity summaries domestic production and uses u s salient statistics recycling import sources tariff depletion allowance government stockpile events trends and issues world production reserves and reserve base world resources and substitutes.
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Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors.
TL;DR: Current understanding of the regulatory mechanisms of NLRP3 inflammasome activation as well as inhibitors that specifically and directly targetNLRP3 are summarized.