Subcortical Contributions to Massive Cortical Reorganizations
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Evidence from noninvasive is capable of extensive reorganization came from a reimaging of evoked activity in the brains of humans with port of a single raccoon that had lost a forearm at some arm amputations that cortex formerly devoted to the unknown time prior to its capture.About:
This article is published in Neuron.The article was published on 1999-04-01 and is currently open access. It has received 110 citations till now.read more
Citations
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The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats.
Florence M. Bareyre,Florence M. Bareyre,Martin Kerschensteiner,Martin Kerschensteiner,Olivier Raineteau,Thomas C. Mettenleiter,Oliver Weinmann,Martin E. Schwab +7 more
TL;DR: The anatomical basis of this recovery was investigated and it was found that after incomplete spinal cord injury in rats, transected hindlimb corticospinal tract axons sprouted into the cervical gray matter to contact short and long propriospinal neurons (PSNs).
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Phantom limb pain: a case of maladaptive CNS plasticity?
TL;DR: Evidence for putative pathophysiological mechanisms with an emphasis on central, and in particular cortical, changes is discussed and suggestions for innovative interventions aimed at alleviating phantom pain are derived.
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Neural plasticity after peripheral nerve injury and regeneration.
TL;DR: An important direction for ongoing research is the development of therapeutic strategies that enhance axonal regeneration, promote selective target reinnervation, but are also able to modulate central nervous system reorganization, amplifying those positive adaptive changes that help to improve functional recovery but also diminishing undesirable consequences.
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Cortical excitation and chronic pain.
TL;DR: This review paper will critically examine the current literature and propose a cortical network model for chronic pain, which is based on human and mouse studies and molecular and synaptic mechanisms underlying relevant cortical plasticity.
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Thalamocortical development: how are we going to get there?
TL;DR: The arealization of the mammalian cortex is believed to be controlled by a combination of intrinsic factors that are expressed in the cortex, and external signals, some of which are mediated through thalamic input.
References
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Neurotrophins and neuronal plasticity.
TL;DR: A role for NTs as selective retrograde messengers that regulate synaptic efficacy is suggested, based on evidence that NT synthesis is rapidly regulated by neuronal activity and that NTs are released in an activity-dependent manner from neuronal dendrites.
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Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation
Herta Flor,Thomas Elbert,Stefan Knecht,Christian Wienbruch,Christo Pantev,Niels Birbaumer,Wolfgang Larbig,Edward Taub +7 more
TL;DR: A very strong direct relationship is reported between the amount of cortical reorganization and the magnitude of phantom limb pain (but not non-painful phantom phenomena) experienced after arm amputation, indicating that phantom-limb pain is related to, and may be a consequence of, plastic changes in primary somatosensory cortex.
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Somatosensory cortical map changes following digit amputation in adult monkeys
Michael M. Merzenich,R. J. Nelson,Michael P. Stryker,Max S. Cynader,Axel Schoppmann,John M. Zook +5 more
TL;DR: The cortical representations of the hand in area 3b in adult owl monkeys were defined with use of microelectrode mapping techniques 2–8 months after surgical amputation of digit 3, or of both digits 2 and 3.
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Massive cortical reorganization after sensory deafferentation in adult macaques
Tim P. Pons,Preston E. Garraghty,Alexander K. Ommaya,Jon H. Kaas,Edward Taub,Mortimer Mishkin +5 more
TL;DR: The results show the need for a reevaluation of both the upper limit of cortical reorganization in adult primates and the mechanisms responsible for it.
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Axonal sprouting accompanies functional reorganization in adult cat striate cortex.
TL;DR: It is reported here that structural changes in the form of axonal sprouting of long-range laterally projecting neurons accompany topographic remodelling of the visual cortex.