Subretinal drusenoid deposits in non-neovascular age-related macular degeneration: morphology, prevalence, topography, and biogenesis model.
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Cites background from "Subretinal drusenoid deposits in no..."
...Between the choroid and the RPE is BrM, a laminar extracellular matrix (ECM) of collagen and elastin (16)....
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...Other extracellular lesions between the photoreceptors and RPE, called subretinal drusenoid deposits, are observed in many patients (Figure 1b) and can confer risk for AMD progression independent of drusen (16, 122)....
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"Subretinal drusenoid deposits in no..." refers methods in this paper
...Lesion thicknesses in foveal sections of 20 nonneovascular AMD eyes and plotted for comparison with the spatial density (cells per square millimeter) of photoreceptor inner segments along the horizontal meridian in adult human retina.(21) In this log plot, zero densities and thicknesses are not shown....
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...Thirteen locations were #1 mm of the foveal center where neurosensory retina cell density gradients change rapidly.(20,21) At each location, layer thicknesses were measured using the Segmented Lengths tool and layer-appropriate annotations chosen from a menu....
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1,653 citations
"Subretinal drusenoid deposits in no..." refers methods in this paper
...Thirteen locations were #1 mm of the foveal center where neurosensory retina cell density gradients change rapidly.(20,21) At each location, layer thicknesses were measured using the Segmented Lengths tool and layer-appropriate annotations chosen from a menu....
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1,172 citations
"Subretinal drusenoid deposits in no..." refers background in this paper
...Several salient features of reticular pseudodrusen can be related to our current or past(7) histologic data: 1) Descriptions of interlacing yellow material or networks.(29,44) 2) High prevalence in AMD eyes, especially geographic atrophy,(45) with prevalence estimates varying widely with detection method(45) and patient population (Table 2)....
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"Subretinal drusenoid deposits in no..." refers background in this paper
...Fewer than half subserve lipid metabolism.(68) Brain cerebrospinal fluid, embryologically equivalent to the subretinal space, also harbors HDL-like lipoproteins containing apoE....
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