Patent•
Substituted indenyl acetic acids
01 May 1970-
TL;DR: In this article, the authors present a survey of INDENYL ACETIC ACIDS and non-toXIC PHARMACEUTICALLY ACCEPTABLE AMIDES, ESTERS, and SALTS.
Abstract: NEW SUBSTITUTED INDENYL ACETIC ACIDS AND NONTOXIC PHARMACEUTICALLY ACCEPTABLE AMIDES, ESTERS AND SALTS DERIVED THEREFROM. THE SUBSTITUTED INDENYL ACETIC ACIDS DISCLOSED HEREIN HAVE ANTI-INFLAMMATORY, ANTI-PYRETIC AND ANALGESIC ACTIVITY. ALSO INCLUDED HEREIN ARE METHODS OF PREPARING SAID INDENYL ACETIC ACID COMPOUNDS, PHARMACEUTICAL COMPOSITIONS HAVING SAID INDENYL ACETIC ACID COMPOUNDS AS AN ACTIVE INGREDIENT AND METHODS OF TREATING FLAMMATION BY ADMINISTERING THESE PARTICULAR COMPOSITIONS TO PATIENTS.
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Patent•
12 Nov 1993TL;DR: In this paper, specific inhibitors of cyclooxygenase-2 are presented for specific disease states such as inflammation, pain and fever, and are non-ulcerogenic.
Abstract: Compounds of the structures shown below are specific inhibitors of cyclooxygenase-2 useful in the treatment of cyclooxygenase-2 mediated disease states such as inflammation, pain and fever, and are non-ulcerogenic. ##STR1##
154 citations
Patent•
22 May 1995TL;DR: In this paper, a novel compound of Formula I as well as a method of treating inflammation and, in particular, cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of formula I.
Abstract: The invention encompasses the novel compound of Formula I as well as a method of treating inflammation and, in particular, cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of inflammation and, in particular, cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
146 citations
Patent•
21 May 1996TL;DR: In this article, a novel compound of Formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases is described, and certain pharmaceutical compositions for treatment of C2-mediated diseases comprising compounds of formula (I).
Abstract: The invention encompasses the novel compound of Formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula (I).
122 citations
Patent•
22 May 1995TL;DR: In this article, a novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of formula I.
Abstract: The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
118 citations
Patent•
27 Oct 1990
TL;DR: There are disclosed compounds of the formula: A(CH2)nO-B, wherein A is C4-C8 alkyl, phenoxyethyl, phenoxyphenyl or a group having formula (a) or (b), wherein X is -N- or (c); Z is (d), (e), (f), (g), -S- or -O-; R1 is hydrogen, lower alkyls, phenyl, or phenyl substituted with trifluoromethyl; R2 is hydrogen or lower al
Abstract: There are disclosed compounds of the formula: A(CH2)nO-B, wherein A is C4-C8 alkyl, phenoxyethyl, phenoxyphenyl or a group having formula (a) or (b), wherein X is -N- or (c); Z is (d), (e), (f), (g), -S- or -O-; R1 is hydrogen, lower alkyl, phenyl or phenyl substituted with trifluoromethyl; R2 is hydrogen or lower alkyl; or R?1 and R2? taken together form a benzen ring; R3 is hydrogen or lower alkyl; n is 1-2; B is (h), (i), (j) or (k); wherein R4 is -CO?2R?2, (l), (m), (n), (o) or (p); m is 0-3; R5 is (q); or phenyl or phenyl substituted by halo, lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl; R6 is A(CH?2?)nO- or halo; with the proviso that when R?6? is halo, R5 is (r); R7 is lower alkyl; Y is -CH?2?- or -O-; R?8? is lower alkyl or -(CH?2?)mCO2R?3; R9? is (s) or -CH?2?R?10; R10? is lower alkyl, phenyl, phenyl substituted with carboxy, halo, loweralkylthio or loweralkylsulfinyl, pyridyl, furanyl or quinolinyl; R11 is lower alkyl or phenyl; and the pharmacologically acceptable salts thereof, and their use in the treatment of inflammatory conditions, such as rheumatoid arthritis, ulcerative colitis, psoriasis and other immediate hypersensitivity reactions; in the treatment of leukotriene-mediated naso-bronchial obstructive air-passageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like; and as gastric cytoprotective agents.
92 citations
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