Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach
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Cites methods from "Subunit Composition of Synaptic AMP..."
...by whole cell recording, also as previously described (Lu et al., 2009)....
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...Slices from transgenic mice and wild-type littermates were interleaved, and the experimenter was blind to genotype. mEPSCs were monitored by whole cell recording, also as previously described (Lu et al., 2009)....
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...Transverse 300–400 mm hippocampal slices were prepared from 24- to 36-dayold animals hemizygous for the human asyn transgene and from wild-type littermates, and field EPSPs evoked in CA1 stratum as previously described (Lu et al., 2009)....
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783 citations
Cites background from "Subunit Composition of Synaptic AMP..."
...The major forms of receptors in the hippocampus include GluA1/2 and GluA2/3 heteromers as well as GluA1 homomers (Lu et al., 2009; Wenthold et al., 1996)....
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589 citations
References
4,112 citations
"Subunit Composition of Synaptic AMP..." refers background in this paper
...D) (Collingridge et al., 2008), contribute to the formation of heterotetrameric receptors (Dingledine et al., 1999; Hollmann and Heinemann, 1994; Mayer and Armstrong, 2004; Seeburg, 1993)....
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..., 2008), contribute to the formation of heterotetrameric receptors (Dingledine et al., 1999; Hollmann and Heinemann, 1994; Mayer and Armstrong, 2004; Seeburg, 1993)....
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4,079 citations
"Subunit Composition of Synaptic AMP..." refers background in this paper
...D) (Collingridge et al., 2008), contribute to the formation of heterotetrameric receptors (Dingledine et al., 1999; Hollmann and Heinemann, 1994; Mayer and Armstrong, 2004; Seeburg, 1993)....
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...It has long been known that edited GluA2 subunits, unlike other subunits, produce very small currents as homomeric channels in heterologous expression systems (Burnashev et al., 1992; Hollmann and Heinemann, 1994)....
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..., 2008), contribute to the formation of heterotetrameric receptors (Dingledine et al., 1999; Hollmann and Heinemann, 1994; Mayer and Armstrong, 2004; Seeburg, 1993)....
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2,587 citations
"Subunit Composition of Synaptic AMP..." refers background or result in this paper
...In contrast, a number of studies have suggested that the GluA2 subunit dictates the removal of AMPARs from the synapse during LTD (Bredt and Nicoll, 2003; Collingridge et al., 2004; Malinow and Malenka, 2002; Shepherd and Huganir, 2007)....
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...Since the discovery of silent synapses, AMPAR trafficking has been a leading molecular mechanism underlying synaptic plasticity (Bredt and Nicoll, 2003; Kerchner and Nicoll, 2008; Malinow and Malenka, 2002; Shepherd and Huganir, 2007)....
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...Implications for AMPAR Trafficking Since the discovery of silent synapses, AMPAR trafficking has been a leading molecular mechanism underlying synaptic plasticity (Bredt and Nicoll, 2003; Kerchner and Nicoll, 2008; Malinow and Malenka, 2002; Shepherd and Huganir, 2007)....
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...However, previous genetic evidence does not support a necessary role of GluA1 and GluA2 in LTP and LTD, respectively....
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...As has been reported before, the I/Vs of AMPAR EPSCs are near linear (Adesnik and Nicoll, 2007; Bredt and Nicoll, 2003; Hestrin et al., 1990; Malinow and Malenka, 2002; Shepherd and Huganir, 2007), suggesting that virtually all synaptic AMPARs contain the GluA2 subunit....
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1,550 citations
"Subunit Composition of Synaptic AMP..." refers background in this paper
...Based on a variety of experiments in which GluA subunits were overexpressed in culture preparations, a leading model for constitutive and activity-dependent AMPAR trafficking has been advanced (Hayashi et al., 2000; Malinow and Malenka, 2002; Passafaro et al., 2001; Shi et al., 2001)....
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1,445 citations
"Subunit Composition of Synaptic AMP..." refers background in this paper
...This unique property, conferred by the presence of the GluA2 subunit, is due to the Arg607 residue introduced into the GluA2 pore loop by RNA editing at the Q/R site (Sommer et al., 1991)....
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