Sucrose and inulin space measurements of cerebral cortex in four mammalian species.
01 Nov 1970-American Journal of Physiology (American Physiological Society)-Vol. 219, Iss: 5, pp 1528-1533
About: This article is published in American Journal of Physiology.The article was published on 1970-11-01. It has received 192 citations till now.
Citations
More filters
1,337 citations
TL;DR: Experimental studies with the real-time iontophoresis method employing the cation tetramethylammonium in normal brain tissue improve the conception of ECS structure and the roles of glia and extracellular matrix in modulating the ECS microenvironment.
Abstract: Diffusion in the extracellular space (ECS) of the brain is constrained by the volume fraction and the tortuosity and a modified diffusion equation represents the transport behavior of many molecule...
1,215 citations
TL;DR: Data support the feasibility of extrasynaptic or volume transmission in the extracellular space by measuring the volume fraction and tortuosity, a measure of hindrance of cellular obstructions.
880 citations
TL;DR: Article de synthese sur la technique de microdialyse permettant de determiner en continu et in vivo les concentrations des substances interstitielles dans l'encephale.
662 citations
TL;DR: These studies indicated that the transport of AIB into brain cells was approximately 110 to 265 times greater than that across normal brain capillaries per unit mass of brain tissue, and that the BBB limits blood-to-brain cell transport of this amino acid.
Abstract: The transport of α-aminoisobutyric acid (AIB), N-methyl-AIB (MeAIB), and diethylenetriaminepentaacetic acid (DTPA) from blood to brain was measured over different experimental periods in eight regi...
515 citations