Journal ArticleDOI
Sugar transport across the blood-brain barrier
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This article is published in American Journal of Physiology.The article was published on 1970-11-01. It has received 132 citations till now. The article focuses on the topics: Blood–brain barrier.read more
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Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18)2-fluoro-2-deoxy-D-glucose: validation of method.
Michael E. Phelps,Michael E. Phelps,Sung-Cheng Huang,Sung-Cheng Huang,Edward J. Hoffman,Edward J. Hoffman,Carl Selin,Carl Selin,L. Sokoloff,L. Sokoloff,David E. Kuhl,David E. Kuhl +11 more
TL;DR: The data indicate that cerebral FDG‐6‐PO4 in humans increases for about 90 minutes, plateaus, and then slowly decreases, and that cerebral blood FDG activity levels were found to be a minor fraction of tissue activity.
Journal ArticleDOI
Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection
TL;DR: Saturability of D-glucose uptake was demonstrated and evidence presented that all of the five hexoses measurably taken up by brain shared a common carrier, two blood-brain barrier carrier systems for amino acids.
Journal ArticleDOI
Transport of metabolic substrates through the blood-brain barrier.
TL;DR: The non-saturable component of BBB transport of metabolic substrates varies over a 30-fold range and probably reflects transport via either very low affinity, high capacity systems, or via free diffusion.
Journal ArticleDOI
Glucose metabolic rate kinetic model parameter determination in humans: the lumped constants and rate constants for [18F]fluorodeoxyglucose and [11C]deoxyglucose.
Martin Reivich,Abass Alavi,Alfred P. Wolf,Joanna S. Fowler,J.A.G. Russell,Carroll D. Arnett,Robert R. MacGregor,Chyng-Yann Shiue,Harold L. Atkins,A. Anand,R. Dann,Joel H. Greenberg +11 more
TL;DR: Using the rate constants and lumped constants determined in humans for the glucose metabolic rate kinetic model used to measure local cerebral glucose consumption, the average whole-brain metabolic rates for glucose in normal subjects measured with [18F]FDG and [11C]DG are 5.66 ± 0.37 (n = 6) and 4.99 mg/100 g/min, respectively.
Journal ArticleDOI
Kinetic analysis of blood-brain barrier transport of amino acids
TL;DR: The Michaelis-Menten kinetics of blood-brain barrier transport of fourteen amino acids was investigated with a tissue-sampling, single-injection technique in the anesthetized rat to determine transport V values and determine brain clearance of tracer concentration of amino acid.