Superoxide Radical and Superoxide Dismutases
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Cites background or methods from "Superoxide Radical and Superoxide D..."
...Similarly, luminol and lucigenin may also produce O2 _• during their oxidation, leading to the false conclusion that O2 _• was actually formed in the process (Liochev & Fridovich, 1998)....
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...Superoxide is enzymatically converted to H2O2 by a family of metalloenzymes called superoxide dismutases (SOD; Fridovich, 1995)....
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...Many of these methods rely on the redox properties of specific ROS or RNS, and therefore are prone to artifacts caused by species of similar reactivity or by reactive intermediates produced by the probe itself (Picker & Fridovich, 1984; Faulkner & Fridovich, 1993; Liochev & Fridovich, 1995, 1998)....
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...For example, a research group concluded that O2 _• was produced by the enzyme glucose oxidase because superoxide dismutase inhibited the reduction of nitroblue tetrazolium in the presence of glucose, when in reality the probe was reacting with the enzyme’s prosthetic group and O2 _• was formed after this reaction (Al-Bekairi et al. 1994; Liochev & Fridovich, 1995)....
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...…enzyme glucose oxidase because superoxide dismutase inhibited the reduction of nitroblue tetrazolium in the presence of glucose, when in reality the probe was reacting with the enzyme’s prosthetic group and O2 _• was formed after this reaction (Al-Bekairi et al. 1994; Liochev & Fridovich, 1995)....
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Cites background from "Superoxide Radical and Superoxide D..."
...Hence, the toxicity of excess O2 is thought to be due (Fridovich 1995) to increased formation of O 2 –....
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...Hence, the toxicity of excess O2 is thought to be due (Fridovich 1995) to increased formation of O 2 ....
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...All parts of the nervous system contain SODs, enzymes that remove O 2 by catalyzing its dismutation, one O 2 being reduced to H2O2 and another oxidized to O2 (Fridovich 1989, 1995; Halliwell 2001; Liochev and Fridovich 2005) 2O 2 þ 2Hþ !...
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References
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