Superoxide Reductase as a Unique Defense System against Superoxide Stress in the Microaerophile Treponema pallidum
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TLDR
A gene in T. pallidum is described with sequence homologies to a new class of antioxidant systems, named superoxide reductases, recently isolated from sulfate-reducing bacteria, and the question of the importance of superoxide reductionases in mechanisms for detoxifying superoxide radicals is raised.About:
This article is published in Journal of Biological Chemistry.The article was published on 2000-09-01 and is currently open access. It has received 67 citations till now. The article focuses on the topics: Superoxide reductase activity & Superoxide reductase.read more
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Reactive oxygen species, antioxidants, and the mammalian thioredoxin system.
Jonas Nordberg,Elias S.J. Arnér +1 more
TL;DR: The TrxR-catalyzed regeneration of several antioxidant compounds, including ascorbic acid (vitamin C), selenium-containing substances, lipoic acid, and ubiquinone are summarized.
Journal ArticleDOI
Superoxide dismutases and superoxide reductases
Yuewei Sheng,Isabel A. Abreu,Diane E. Cabelli,Michael J. Maroney,Anne-Frances Miller,Miguel Teixeira,Joan Selverstone Valentine,Joan Selverstone Valentine +7 more
TL;DR: The SORs and three very different types of SOD enzymes are redox-active metalloenzymes that have evolved entirely independently from one another for the purpose of lowering superoxide concentrations, suggesting that, from the start of the rise of O2 on Earth, the chemistry of superoxide has been an important factor during evolution.
Journal ArticleDOI
Enzymes from extremophiles.
TL;DR: Enzymes from thermophilic organisms have found the most practical commercial use to date because of their overall inherent stability, which has led to a greater understanding of stability factors involved in adaptation of these enzymes to their unusual environments.
Journal ArticleDOI
Biological Basis for Syphilis
TL;DR: Syphilis is a chronic sexually transmitted disease caused by Treponema pallidum subsp.
Journal ArticleDOI
Comparative Genomics of Two Leptospira interrogans Serovars Reveals Novel Insights into Physiology and Pathogenesis
Ana L. T. O. Nascimento,Albert I. Ko,Albert I. Ko,Elizabeth A. L. Martins,Claudia Barros Monteiro-Vitorello,Paulo L. Ho,David A. Haake,David A. Haake,Sergio Verjovski-Almeida,Rudy A. Hartskeerl,Marilis V. Marques,Mariana Cabral de Oliveira,Carlos Frederico Martins Menck,Luciana C. C. Leite,Helaine Carrer,Luiz Lehmann Coutinho,Wim Degrave,Odir Antônio Dellagostin,Hamza El-Dorry,Emer S. Ferro,Maria Inês Tiraboschi Ferro,Luiz Roberto Furlan,Marcia Gamberini,E. A. Giglioti,Aristóteles Góes-Neto,Gustavo H. Goldman,Maria Helena S. Goldman,Ricardo Harakava,Selma M. B. Jeronimo,Inácio L.M. Junqueira-de-Azevedo,Edna Teruko Kimura,Eiko E. Kuramae,Eliana Gertrudes de Macedo Lemos,Manoel Victor Franco Lemos,Celso Luis Marino,Luiz R. Nunes,R. C. de Oliveira,Gonçalo A.G. Pereira,Marcelo S. Reis,A. Schriefer,Walter José Siqueira,P. Sommer,Siu Mui Tsai,Andrew J. G. Simpson,Jesus Aparecido Ferro,Luis Eduardo Aranha Camargo,João Paulo Kitajima,João C. Setubal,M. A. Van Sluys +48 more
TL;DR: Genome sequence analysis elucidates many of the novel aspects of leptospiral physiology relating to energy metabolism, oxygen tolerance, two-component signal transduction systems, and mechanisms of pathogenesis.
References
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TL;DR: The demonstration that O2·- can reduce ferricytochrome c and tetranitromethane, and that superoxide dismutase, by competing for the superoxide radicals, can markedly inhibit these reactions, is demonstrated.
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Superoxide Radical and Superoxide Dismutases
TL;DR: O2- oxidizes the [4Fe-4S] clusters of dehydratases, such as aconitase, causing-inactivation and release of Fe(II), which may then reduce H2O2 to OH- +OH..
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Biochemistry of Oxidative Stress
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