Supramolecular Amphiphiles Based on Host-Guest Molecular Recognition Motifs.
About: This article is published in Chemical Reviews.The article was published on 2015-02-26. It has received 783 citations till now. The article focuses on the topics: Supramolecular chemistry & Molecular recognition.
Citations
More filters
554 citations
TL;DR: This review discusses one-dimensional supramolecular polymers that form in aqueous media and focuses on recent studies that address key challenges in the field, providing mechanistic understanding, rational polymer design, important functionality, robustness, or unusual thermodynamic and kinetic properties.
Abstract: This review discusses one-dimensional supramolecular polymers that form in aqueous media. First, naturally occurring supramolecular polymers are described, in particular, amyloid fibrils, actin filaments, and microtubules. Their structural, thermodynamic, kinetic, and nanomechanical properties are highlighted, as well as their importance for the advancement of biologically inspired supramolecular polymer materials. Second, five classes of synthetic supramolecular polymers are described: systems based on (1) hydrogen-bond motifs, (2) large π-conjugated surfaces, (3) host–guest interactions, (4) peptides, and (5) DNA. We focus on recent studies that address key challenges in the field, providing mechanistic understanding, rational polymer design, important functionality, robustness, or unusual thermodynamic and kinetic properties.
549 citations
01 Jan 2012
TL;DR: In this paper, the use of mesoporous silica nanoparticles (MSNPs) has been investigated for the delivery of bioactive agents within living tissue, where the payload "cargo" molecules can be stored within this robust domain, which is stable to a wide range of chemical conditions.
Abstract: Medicine can benefit significantly from advances in nanotechnology because nanoscale assemblies promise to improve on previously established therapeutic and diagnostic regimes. Over the past decade, the use of delivery platforms has attracted attention as researchers shift their focus toward new ways to deliver therapeutic and/or diagnostic agents and away from the development of new drug candidates. Metaphorically, the use of delivery platforms in medicine can be viewed as the "bow-and-arrow" approach, where the drugs are the arrows and the delivery vehicles are the bows. Even if one possesses the best arrows that money can buy, they will not be useful if one does not have the appropriate bow to deliver the arrows to their intended location. Currently, many strategies exist for the delivery of bioactive agents within living tissue. Polymers, dendrimers, micelles, vesicles, and nanoparticles have all been investigated for their use as possible delivery vehicles. With the growth of nanomedicine, one can envisage the possibility of fabricating a theranostic vector that could release powerful therapeutics and diagnostic markers simultaneously and selectively to diseased tissue. In our design of more robust theranostic delivery systems, we have focused our attention on using mesoporous silica nanoparticles (SNPs). The payload "cargo" molecules can be stored within this robust domain, which is stable to a wide range of chemical conditions. This stability allows SNPs to be functionalized with stimulus-responsive mechanically interlocked molecules (MIMs) in the shape of bistable rotaxanes and psuedorotaxanes to yield mechanized silica nanoparticles (MSNPs). In this Account, we chronicle the evolution of various MSNPs, which came about as a result of our decade-long collaboration, and discuss advances in the synthesis of novel hybrid SNPs and the various MIMs which have been attached to their surfaces. These MIMs can be designed in such a way that they either change shape or shed off some of their parts in response to a specific stimulus, such as changes in redox potential, alterations in pH, irradiation with light, or the application of an oscillating magnetic field, allowing a theranostic payload to be released from the nanopores to a precise location at the appropiate time. We have also shown that these integrated systems can operate not only within cells, but also in live animals in response to pre-existing biological triggers. Recognizing that the theranostics of the future could offer a fresh approach to the treatment of degenerative diseases including cancer, we aim to start moving out of the chemical domain and into the biological one. Some MSNPs are already being tested in biological systems.
498 citations
TL;DR: A review summarizing the progress of supramolecular chemotherapy in cancer treatment based on host-guest recognition and guidance on the design of new targeting supramolescular chemotherapy combining diagnostic and therapeutic functions is presented.
Abstract: Chemotherapy is currently one of the most effective ways to treat cancer. However, traditional chemotherapy faces several obstacles to clinical trials, such as poor solubility/stability, non-targeting capability and uncontrollable release of the drugs, greatly limiting their anticancer efficacy and causing severe side effects towards normal tissues. Supramolecular chemotherapy integrating non-covalent interactions and traditional chemotherapy is a highly promising candidate in this regard and can be appropriately used for targeted drug delivery. By taking advantage of supramolecular chemistry, some limitations impeding traditional chemotherapy for clinical applications can be solved effectively. Therefore, we present here a review summarizing the progress of supramolecular chemotherapy in cancer treatment based on host–guest recognition and provide guidance on the design of new targeting supramolecular chemotherapy combining diagnostic and therapeutic functions. Based on a large number of state-of-the-art studies, our review will advance supramolecular chemotherapy on the basis of host–guest recognition and promote translational clinical applications.
485 citations
TL;DR: This Review provides an account of the recent advancements in reversible photocontrol of the structures and functions of photochromic nanosystems and their applications and outlines the challenges that need to be addressed and the opportunities that can be tapped into.
Abstract: The ability to manipulate the structure and function of promising nanosystems via energy input and external stimuli is emerging as an attractive paradigm for developing reconfigurable and programmable nanomaterials and multifunctional devices. Light stimulus manifestly represents a preferred external physical and chemical tool for in situ remote command of the functional attributes of nanomaterials and nanosystems due to its unique advantages of high spatial and temporal resolution and digital controllability. Photochromic moieties are known to undergo reversible photochemical transformations between different states with distinct properties, which have been extensively introduced into various functional nanosystems such as nanomachines, nanoparticles, nanoelectronics, supramolecular nanoassemblies, and biological nanosystems. The integration of photochromism into these nanosystems has endowed the resultant nanostructures or advanced materials with intriguing photoresponsive behaviors and more sophisticated functions. In this Review, we provide an account of the recent advancements in reversible photocontrol of the structures and functions of photochromic nanosystems and their applications. The important design concepts of such truly advanced materials are discussed, their fabrication methods are emphasized, and their applications are highlighted. The Review is concluded by briefly outlining the challenges that need to be addressed and the opportunities that can be tapped into. We hope that the review of the flourishing and vibrant topic with myriad possibilities would shine light on exploring the future nanoworld by encouraging and opening the windows to meaningful multidisciplinary cooperation of engineers from different backgrounds and scientists from the fields such as chemistry, physics, engineering, biology, nanotechnology and materials science.
463 citations
References
More filters
Book•
01 Jan 1985
TL;DR: The forces between atoms and molecules are discussed in detail in this article, including the van der Waals forces between surfaces, and the forces between particles and surfaces, as well as their interactions with other forces.
Abstract: The Forces between Atoms and Molecules. Principles and Concepts. Historical Perspective. Some Thermodynamic Aspects of Intermolecular Forces. Strong Intermolecular Forces: Covalent and Coulomb Interactions. Interactions Involving Polar Molecules. Interactions Involving the Polarization of Molecules. van der Waals Forces. Repulsive Forces, Total Intermolecular Pair Potentials, and Liquid Structure. Special Interactions. Hydrogen-Bonding, Hydrophobic, and Hydrophilic Interactions. The Forces between Particles and Surfaces. Some Unifying Concepts in Intermolecular and Interparticle Forces. Contrasts between Intermolecular, Interparticle, and Intersurface Forces. van der Waals Forces between Surfaces. Electrostatic Forces between Surfaces in Liquids. Solvation, Structural and Hydration Forces. Steric and Fluctuation Forces. Adhesion. Fluid-Like Structures and Self-Assembling Systems. Micelles, Bilayers, and Biological Membranes. Thermodynamic Principles of Self-Assembly. Aggregation of Amphiphilic Molecules into Micelles, Bilayers, Vesicles, and Biological Membranes. The Interactions between Lipid Bilayers and Biological Membranes. References. Index.
18,048 citations
12,178 citations
26 May 1995
TL;DR: From molecular to supramolescular chemistry: concepts and language of supramolecular chemistry, molecular recognition, information, complementarity molecular receptors - design principles and more.
Abstract: Part 1 From molecular to supramolecular chemistry: concepts and language of supramolecular chemistry. Part 2 Molecular recognition: recognition, information, complementarity molecular receptors - design principles spherical recognition - cryptates of metal cations tetrahedral recognition by macrotricyclic cryptands recognition of ammonium ions and related substrates binding and recognition of neutral moelcules. Part 3 Anion co-ordination chemistry and the recognition of anionic substrates. Part 4 Coreceptor molecules and multiple recognition: dinuclear and polynuclear metal ion cryptates linear recognition of molecular length by ditopic coreceptors heterotopic coreceptors - cyclophane receptors, amphiphilic receptors, large molecular cage multiple recognition in metalloreceptors supramolecular dynamics. Part 5 Supramolecular reactivity and catalysis: catalysis by reactive macrocyclic cation receptor molecules catalysis by reactive anion receptor molecules catalysis with cyclophane type receptors supramolecular metallo-catalysis cocatalysis - catalysis of synthetic reactions biomolecular and abiotic catalysis. Part 6 Transport processes and carrier design: carrier-mediated transport cation-transport processes - cation carriers anion transport processes - anion carriers coupled transport processes electron-coupled transpoort in a redox gradient proton-coupled transport in a pH gradient light-coupled transport processes transfer via transmembrane channels. Part 7 From supermolecules to polymolecular assemblies: heterogeneous molecular recognition - supramolecular solid materials from endoreceptors to exoreceptors - molecular recognition at surfaces molecular and supramolecular morphogenesis supramolecular heterogeneous catalysis. Part 8 Molecular and supramolecular devices: molecular recognition, information and signals - semiochemistry supramolecular photochemistry - molecular and supramolecular photonic devices light conversion and energy transfer devices photosensitive molecular receptors photoinduced electron transfer in photoactive devices photoinduced reactions in supramolecular species non-linear optical properties of supramolecular species supramolecular effects in photochemical hole burning molecular and supramolecular electronic devices supramolecular electrochemistry electron conducting devices - molecular wires polarized molecular wires - rectifying devices modified and switchable molecular wires molecular magnetic devices molecular and supramolecular ionic devices tubular mesophases. (Part contents).
8,168 citations
TL;DR: Aggregation greatly boosts emission efficiency of the silole, turning it from a weak luminophor into a strong emitter.
5,916 citations
TL;DR: In this critical review, recent progress in the area ofAIE research is summarized and typical examples of AIE systems are discussed, from which their structure-property relationships are derived.
Abstract: Luminogenic materials with aggregation-induced emission (AIE) attributes have attracted much interest since the debut of the AIE concept in 2001. In this critical review, recent progress in the area of AIE research is summarized. Typical examples of AIE systems are discussed, from which their structure–property relationships are derived. Through mechanistic decipherment of the photophysical processes, structural design strategies for generating new AIE luminogens are developed. Technological, especially optoelectronic and biological, applications of the AIE systems are exemplified to illustrate how the novel AIE effect can be utilized for high-tech innovations (183 references).
4,996 citations