Journal ArticleDOI
Surface antigen(s) of SV40-transformed tumor cells.
Pekka Häyry,Vittorio Defendi +1 more
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TLDR
Evidence is found that the serologically detected neoantigen(s) on the SV40-transformed cell surface were not virus-specific products, but rather components of the normal cell surface exposed by a virus- specific “uncovering” mechanism.About:
This article is published in Virology.The article was published on 1970-05-01. It has received 106 citations till now. The article focuses on the topics: Forssman antigen & Antigen.read more
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Monoclonal antibodies specific for simian virus 40 tumor antigens.
TL;DR: Thirty hybridomas that secrete immunoglobulins against the simian virus 40 tumor antigens were isolated and cloned and large-T antigen was found to have at least one determinant that it shared with small-t antigen and to have a minimum of six unique determinants.
Journal ArticleDOI
Specificity of Virus‐Immune Effector T Cells for H‐2K or H‐2D Compatible Interactions: Implications for H‐Antigen Diversity
TL;DR: There was an all-or-none effect: virus-infected L-929 fibroblasts (L cells, H-2'') were lysed only by H-Z" compatible virusimmune T cells.
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Role of simian virus 40 gene A function in maintenance of transformation.
Joan S. Brugge,Janet S. Butel +1 more
TL;DR: Virus rescued from the mutant-transformed cells by the transfection method was ts, suggesting that the SV40 gene A function, rather than a cellular one, is responsible for the ts behavior of the cells.
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The gix system a cell surface allo-antigen associated with murine leukemia virus; implications regarding chromosomal integration of the viral genome
TL;DR: A cell surface antigen which exhibits mendelian inheritance but which also appears de novo in cells that become productively infected with MuLV (Gross), the wild-type leukemia virus of the mouse, and which invites comparison with the emergence of TL(+) leukemia cells in TL(-) mouse strains.
Journal ArticleDOI
T-Cell Mediated Immunopathology in Viral Infections
TL;DR: Virus-specific cytotoxic T cells are crucially involved in host recovery from primary infection and some forms of virally induced hepatitis or of acquired immunodeficiency may be mediated by immunopathologically active virus-specific T cells.
References
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Journal ArticleDOI
A difference in the architecture of the surface membrane of normal and virally transformed cells
TL;DR: Several tissue culture cell lines that were transformed by a tumor virus have been found to react with an agglutinin, while under identical conditions their untransformed parent cell lines did notagglutinate.
Journal ArticleDOI
Identification of a tumor-specific determinant on neoplastic cell surfaces.
Max M. Burger,Allan R. Goldberg +1 more
TL;DR: It will be demonstrated that the tumorspecific surface site that interacts with the agglutinin contains N-acetyl-glucosamine (GlcNAc), which may be instrumental in deranging control mechanisms, in particular the control of cell division by modifying the permeation of regulatory substances.
Journal ArticleDOI
Some Aspects of Normal and Abnormal Cell Surface Genetics
Edward A. Boyse,Lloyd J. Old +1 more
Journal ArticleDOI
Demonstration of mouse isoantigens at the cellular level by the fluorescent antibody technique
TL;DR: The fluorescent antibody technique has been applied for the demonstration of mouse isoantigens at the cellular level and reactions that were morphologically distinguishable from the specific "ring" reaction and could be easily avoided by reducing the incubation time.
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Restoration of Normal Growth by Covering of Agglutinin Sites on Tumour Cell Surface
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Structural difference in sites on the surface membrane of normal and transformed cells.
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